pathological role of visceral fat accumulation in steatosis, inflammation, and progression of nonalcoholic fatty liver disease
Background Our previous studies have indicated a close association between visceral fat accumulation and hepatic steatosis in nonalcoholic fatty liver disease (NAFLD). This study investigated whether visceral fat accumulation was related to the pathogenesis and disease progression of nonalcoholic st...
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| creator | Eguchi, Yuichiro Mizuta, Toshihiko Sumida, Yoshio Ishibashi, Eriko Kitajima, Yoichiro Isoda, Hiroshi Horie, Hiroko Tashiro, Takaya Iwamoto, Eri Takahashi, Hirokazu Kuwashiro, Takuya Soejima, Shu Kawaguchi, Yasunori Oda, Yasutomo Emura, Sei Iwakiri, Ryuichi Ozaki, Iwata Eguchi, Takahisa Ono, Naofumi Anzai, Keizo Fujimoto, Kazuma Koizumi, Shunzo |
| description | Background Our previous studies have indicated a close association between visceral fat accumulation and hepatic steatosis in nonalcoholic fatty liver disease (NAFLD). This study investigated whether visceral fat accumulation was related to the pathogenesis and disease progression of nonalcoholic steatohepatitis (NASH)/NAFLD. Methods First, a total of 550 subjects who underwent a health checkup and measurement of visceral fat accumulation, done with a bioelectrical impedance analyzer (X-SCAN; Owa Medical, Fukuoka, Japan), were included. The relationship between visceral fat accumulation and biochemical parameters was examined. Second, a total of 74 patients with NASH/NAFLD who underwent liver biopsy were reviewed. Visceral fat accumulation was determined by abdominal computed tomography. The association between visceral fat accumulation and the histopathological grade/stage determined by the NAFLD activity score and Brunt's classification was evaluated. Results There was a significant relationship between visceral fat accumulation and glucose, triglyceride, and alanine aminotransferase (ALT; r = 0.423, P < 0.01). In stepwise regression analysis, visceral fat area (VFA), serum triglyceride level, and serum low-density lipoprotein (LDL)-cholesterol level were selected as predictor variables for serum ALT level, in a continuous manner (serum ALT level = −1.359 + 0.143 × VFA + 0.046 × triglyceride + 0.059 × LDL, R ² = 0.217, P < 0.001). In patients with NASH, there was no correlation between histological grade and the visceral fat volume. Visceral fat accumulation in patients with stage 3/4 advanced NASH was greater than that in patients with stage 1/2 early NASH (P < 0.05). Conclusions These results suggest that visceral fat accumulation plays a role in steatosis and fibrosis in the pathogenesis and prognosis of NAFLD. |
| doi_str_mv | 10.1007/s00535-010-0340-3 |
| format | Article |
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This study investigated whether visceral fat accumulation was related to the pathogenesis and disease progression of nonalcoholic steatohepatitis (NASH)/NAFLD. Methods First, a total of 550 subjects who underwent a health checkup and measurement of visceral fat accumulation, done with a bioelectrical impedance analyzer (X-SCAN; Owa Medical, Fukuoka, Japan), were included. The relationship between visceral fat accumulation and biochemical parameters was examined. Second, a total of 74 patients with NASH/NAFLD who underwent liver biopsy were reviewed. Visceral fat accumulation was determined by abdominal computed tomography. The association between visceral fat accumulation and the histopathological grade/stage determined by the NAFLD activity score and Brunt's classification was evaluated. Results There was a significant relationship between visceral fat accumulation and glucose, triglyceride, and alanine aminotransferase (ALT; r = 0.423, P < 0.01). In stepwise regression analysis, visceral fat area (VFA), serum triglyceride level, and serum low-density lipoprotein (LDL)-cholesterol level were selected as predictor variables for serum ALT level, in a continuous manner (serum ALT level = −1.359 + 0.143 × VFA + 0.046 × triglyceride + 0.059 × LDL, R ² = 0.217, P < 0.001). In patients with NASH, there was no correlation between histological grade and the visceral fat volume. Visceral fat accumulation in patients with stage 3/4 advanced NASH was greater than that in patients with stage 1/2 early NASH (P < 0.05). Conclusions These results suggest that visceral fat accumulation plays a role in steatosis and fibrosis in the pathogenesis and prognosis of NAFLD.</description><identifier>ISSN: 0944-1174</identifier><identifier>EISSN: 1435-5922</identifier><identifier>DOI: 10.1007/s00535-010-0340-3</identifier><identifier>PMID: 21042922</identifier><language>eng</language><publisher>Japan: Japan : Springer Japan</publisher><subject>Abdominal obesity ; Abdominal Surgery ; Adipocytokine ; Adult ; Aged ; Alanine transaminase ; Alanine Transaminase - blood ; Analysis ; Biopsy ; Blood cholesterol ; Central obesity ; Cholesterol, LDL - blood ; Classification ; Colorectal Surgery ; Computed tomography ; Development and progression ; Disease Progression ; Electric Impedance ; Fatty liver ; Fatty Liver - pathology ; Female ; Fibrosis ; Gastroenterology ; Glucose ; Hepatology ; Humans ; Inflammation ; Inflammation - pathology ; International Forum ; Intra-Abdominal Fat - pathology ; Lipoproteins ; Low density lipoproteins ; Male ; Medical research ; Medicine ; Medicine & Public Health ; Medicine, Experimental ; metabolic syndrome ; Middle Aged ; oxidative stress ; Prognosis ; Regression Analysis ; Retrospective Studies ; steatosis ; Surgical Oncology ; Tomography, X-Ray Computed ; Triglycerides ; Triglycerides - blood ; Type 2 diabetes ; Young Adult</subject><ispartof>Journal of gastroenterology, 2011-01, Vol.46 (1), p.70-78</ispartof><rights>Springer 2010</rights><rights>COPYRIGHT 2011 Springer</rights><rights>Springer 2011</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c589t-c9c5b34ac56ecf5f6f0e962a170bc2a3d7ff35509500728f1f693a1347db9d043</citedby><cites>FETCH-LOGICAL-c589t-c9c5b34ac56ecf5f6f0e962a170bc2a3d7ff35509500728f1f693a1347db9d043</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00535-010-0340-3$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00535-010-0340-3$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21042922$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Eguchi, Yuichiro</creatorcontrib><creatorcontrib>Mizuta, Toshihiko</creatorcontrib><creatorcontrib>Sumida, Yoshio</creatorcontrib><creatorcontrib>Ishibashi, Eriko</creatorcontrib><creatorcontrib>Kitajima, Yoichiro</creatorcontrib><creatorcontrib>Isoda, Hiroshi</creatorcontrib><creatorcontrib>Horie, Hiroko</creatorcontrib><creatorcontrib>Tashiro, Takaya</creatorcontrib><creatorcontrib>Iwamoto, Eri</creatorcontrib><creatorcontrib>Takahashi, Hirokazu</creatorcontrib><creatorcontrib>Kuwashiro, Takuya</creatorcontrib><creatorcontrib>Soejima, Shu</creatorcontrib><creatorcontrib>Kawaguchi, Yasunori</creatorcontrib><creatorcontrib>Oda, Yasutomo</creatorcontrib><creatorcontrib>Emura, Sei</creatorcontrib><creatorcontrib>Iwakiri, Ryuichi</creatorcontrib><creatorcontrib>Ozaki, Iwata</creatorcontrib><creatorcontrib>Eguchi, Takahisa</creatorcontrib><creatorcontrib>Ono, Naofumi</creatorcontrib><creatorcontrib>Anzai, Keizo</creatorcontrib><creatorcontrib>Fujimoto, Kazuma</creatorcontrib><creatorcontrib>Koizumi, Shunzo</creatorcontrib><title>pathological role of visceral fat accumulation in steatosis, inflammation, and progression of nonalcoholic fatty liver disease</title><title>Journal of gastroenterology</title><addtitle>J Gastroenterol</addtitle><addtitle>J Gastroenterol</addtitle><description>Background Our previous studies have indicated a close association between visceral fat accumulation and hepatic steatosis in nonalcoholic fatty liver disease (NAFLD). This study investigated whether visceral fat accumulation was related to the pathogenesis and disease progression of nonalcoholic steatohepatitis (NASH)/NAFLD. Methods First, a total of 550 subjects who underwent a health checkup and measurement of visceral fat accumulation, done with a bioelectrical impedance analyzer (X-SCAN; Owa Medical, Fukuoka, Japan), were included. The relationship between visceral fat accumulation and biochemical parameters was examined. Second, a total of 74 patients with NASH/NAFLD who underwent liver biopsy were reviewed. Visceral fat accumulation was determined by abdominal computed tomography. The association between visceral fat accumulation and the histopathological grade/stage determined by the NAFLD activity score and Brunt's classification was evaluated. Results There was a significant relationship between visceral fat accumulation and glucose, triglyceride, and alanine aminotransferase (ALT; r = 0.423, P < 0.01). In stepwise regression analysis, visceral fat area (VFA), serum triglyceride level, and serum low-density lipoprotein (LDL)-cholesterol level were selected as predictor variables for serum ALT level, in a continuous manner (serum ALT level = −1.359 + 0.143 × VFA + 0.046 × triglyceride + 0.059 × LDL, R ² = 0.217, P < 0.001). In patients with NASH, there was no correlation between histological grade and the visceral fat volume. Visceral fat accumulation in patients with stage 3/4 advanced NASH was greater than that in patients with stage 1/2 early NASH (P < 0.05). Conclusions These results suggest that visceral fat accumulation plays a role in steatosis and fibrosis in the pathogenesis and prognosis of NAFLD.</description><subject>Abdominal obesity</subject><subject>Abdominal Surgery</subject><subject>Adipocytokine</subject><subject>Adult</subject><subject>Aged</subject><subject>Alanine transaminase</subject><subject>Alanine Transaminase - blood</subject><subject>Analysis</subject><subject>Biopsy</subject><subject>Blood cholesterol</subject><subject>Central obesity</subject><subject>Cholesterol, LDL - blood</subject><subject>Classification</subject><subject>Colorectal Surgery</subject><subject>Computed tomography</subject><subject>Development and progression</subject><subject>Disease Progression</subject><subject>Electric Impedance</subject><subject>Fatty liver</subject><subject>Fatty Liver - pathology</subject><subject>Female</subject><subject>Fibrosis</subject><subject>Gastroenterology</subject><subject>Glucose</subject><subject>Hepatology</subject><subject>Humans</subject><subject>Inflammation</subject><subject>Inflammation - pathology</subject><subject>International Forum</subject><subject>Intra-Abdominal Fat - pathology</subject><subject>Lipoproteins</subject><subject>Low density lipoproteins</subject><subject>Male</subject><subject>Medical research</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Medicine, Experimental</subject><subject>metabolic syndrome</subject><subject>Middle Aged</subject><subject>oxidative stress</subject><subject>Prognosis</subject><subject>Regression Analysis</subject><subject>Retrospective Studies</subject><subject>steatosis</subject><subject>Surgical Oncology</subject><subject>Tomography, X-Ray Computed</subject><subject>Triglycerides</subject><subject>Triglycerides - blood</subject><subject>Type 2 diabetes</subject><subject>Young Adult</subject><issn>0944-1174</issn><issn>1435-5922</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNp9kktv1TAQhS0EorcXfgAbiGABi6b4mcTLqioPqRIL6Nqa69gXV058sZNK3fDbmZACAqEqCyvj75zMTA4hzxg9ZZS2bwulSqiaMlpTIWktHpANk1hRmvOHZEO1lDVjrTwix6VcU8oEVd1jcsQZlRyZDfl-gOlrimkfLMQqp-iq5KubUKzLWPAwVWDtPMwRppDGKoxVmRxMqYRygm8-wjD8vDqpYOyrQ0777EpZWDQa0wjRJvxCsIvZdFvFcONy1YfioLgn5JGHWNzTu3NLrt5dfDn_UF9-ev_x_OyytqrTU221VTshwarGWa9846nTDQfW0p3lIPrWe6EU1QrXwjvPfKMFMCHbfqd7KsWWvF59sb9vsyuTGZYRY4TRpbmYjjVK0E53SL65l2RUdLheieeWvPwHvU5zxoEXP_wNjVQaoVcrtIfoDC4sTRns4mnOWiZV1zDBkDr9D4VP74Zg0-h8wPpfArYKbE6lZOfNIYcB8i02aJZwmDUcBsNhlnAYgZrnd_3Ou8H1vxW_0oAAX4GCV-Pe5T8D3ef6YhV5SAb2ORRz9ZkvUWOatZ3m4gc9Ycz_</recordid><startdate>20110101</startdate><enddate>20110101</enddate><creator>Eguchi, Yuichiro</creator><creator>Mizuta, Toshihiko</creator><creator>Sumida, Yoshio</creator><creator>Ishibashi, Eriko</creator><creator>Kitajima, Yoichiro</creator><creator>Isoda, Hiroshi</creator><creator>Horie, Hiroko</creator><creator>Tashiro, Takaya</creator><creator>Iwamoto, Eri</creator><creator>Takahashi, Hirokazu</creator><creator>Kuwashiro, Takuya</creator><creator>Soejima, Shu</creator><creator>Kawaguchi, Yasunori</creator><creator>Oda, Yasutomo</creator><creator>Emura, Sei</creator><creator>Iwakiri, Ryuichi</creator><creator>Ozaki, Iwata</creator><creator>Eguchi, Takahisa</creator><creator>Ono, Naofumi</creator><creator>Anzai, Keizo</creator><creator>Fujimoto, Kazuma</creator><creator>Koizumi, Shunzo</creator><general>Japan : Springer Japan</general><general>Springer Japan</general><general>Springer</general><general>Springer Nature B.V</general><scope>FBQ</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7T5</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>H94</scope><scope>K9-</scope><scope>K9.</scope><scope>KB0</scope><scope>M0R</scope><scope>M0S</scope><scope>M1P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7U7</scope><scope>C1K</scope><scope>7X8</scope></search><sort><creationdate>20110101</creationdate><title>pathological role of visceral fat accumulation in steatosis, inflammation, and progression of nonalcoholic fatty liver disease</title><author>Eguchi, Yuichiro ; Mizuta, Toshihiko ; Sumida, Yoshio ; Ishibashi, Eriko ; Kitajima, Yoichiro ; Isoda, Hiroshi ; Horie, Hiroko ; Tashiro, Takaya ; Iwamoto, Eri ; Takahashi, Hirokazu ; Kuwashiro, Takuya ; Soejima, Shu ; Kawaguchi, Yasunori ; Oda, Yasutomo ; Emura, Sei ; Iwakiri, Ryuichi ; Ozaki, Iwata ; Eguchi, Takahisa ; Ono, Naofumi ; Anzai, Keizo ; Fujimoto, Kazuma ; Koizumi, Shunzo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c589t-c9c5b34ac56ecf5f6f0e962a170bc2a3d7ff35509500728f1f693a1347db9d043</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Abdominal obesity</topic><topic>Abdominal Surgery</topic><topic>Adipocytokine</topic><topic>Adult</topic><topic>Aged</topic><topic>Alanine transaminase</topic><topic>Alanine Transaminase - blood</topic><topic>Analysis</topic><topic>Biopsy</topic><topic>Blood cholesterol</topic><topic>Central obesity</topic><topic>Cholesterol, LDL - blood</topic><topic>Classification</topic><topic>Colorectal Surgery</topic><topic>Computed tomography</topic><topic>Development and progression</topic><topic>Disease Progression</topic><topic>Electric Impedance</topic><topic>Fatty liver</topic><topic>Fatty Liver - pathology</topic><topic>Female</topic><topic>Fibrosis</topic><topic>Gastroenterology</topic><topic>Glucose</topic><topic>Hepatology</topic><topic>Humans</topic><topic>Inflammation</topic><topic>Inflammation - pathology</topic><topic>International Forum</topic><topic>Intra-Abdominal Fat - pathology</topic><topic>Lipoproteins</topic><topic>Low density lipoproteins</topic><topic>Male</topic><topic>Medical research</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Medicine, Experimental</topic><topic>metabolic syndrome</topic><topic>Middle Aged</topic><topic>oxidative stress</topic><topic>Prognosis</topic><topic>Regression Analysis</topic><topic>Retrospective Studies</topic><topic>steatosis</topic><topic>Surgical Oncology</topic><topic>Tomography, X-Ray Computed</topic><topic>Triglycerides</topic><topic>Triglycerides - 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Academic</collection><jtitle>Journal of gastroenterology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Eguchi, Yuichiro</au><au>Mizuta, Toshihiko</au><au>Sumida, Yoshio</au><au>Ishibashi, Eriko</au><au>Kitajima, Yoichiro</au><au>Isoda, Hiroshi</au><au>Horie, Hiroko</au><au>Tashiro, Takaya</au><au>Iwamoto, Eri</au><au>Takahashi, Hirokazu</au><au>Kuwashiro, Takuya</au><au>Soejima, Shu</au><au>Kawaguchi, Yasunori</au><au>Oda, Yasutomo</au><au>Emura, Sei</au><au>Iwakiri, Ryuichi</au><au>Ozaki, Iwata</au><au>Eguchi, Takahisa</au><au>Ono, Naofumi</au><au>Anzai, Keizo</au><au>Fujimoto, Kazuma</au><au>Koizumi, Shunzo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>pathological role of visceral fat accumulation in steatosis, inflammation, and progression of nonalcoholic fatty liver disease</atitle><jtitle>Journal of gastroenterology</jtitle><stitle>J Gastroenterol</stitle><addtitle>J Gastroenterol</addtitle><date>2011-01-01</date><risdate>2011</risdate><volume>46</volume><issue>1</issue><spage>70</spage><epage>78</epage><pages>70-78</pages><issn>0944-1174</issn><eissn>1435-5922</eissn><abstract>Background Our previous studies have indicated a close association between visceral fat accumulation and hepatic steatosis in nonalcoholic fatty liver disease (NAFLD). This study investigated whether visceral fat accumulation was related to the pathogenesis and disease progression of nonalcoholic steatohepatitis (NASH)/NAFLD. Methods First, a total of 550 subjects who underwent a health checkup and measurement of visceral fat accumulation, done with a bioelectrical impedance analyzer (X-SCAN; Owa Medical, Fukuoka, Japan), were included. The relationship between visceral fat accumulation and biochemical parameters was examined. Second, a total of 74 patients with NASH/NAFLD who underwent liver biopsy were reviewed. Visceral fat accumulation was determined by abdominal computed tomography. The association between visceral fat accumulation and the histopathological grade/stage determined by the NAFLD activity score and Brunt's classification was evaluated. Results There was a significant relationship between visceral fat accumulation and glucose, triglyceride, and alanine aminotransferase (ALT; r = 0.423, P < 0.01). In stepwise regression analysis, visceral fat area (VFA), serum triglyceride level, and serum low-density lipoprotein (LDL)-cholesterol level were selected as predictor variables for serum ALT level, in a continuous manner (serum ALT level = −1.359 + 0.143 × VFA + 0.046 × triglyceride + 0.059 × LDL, R ² = 0.217, P < 0.001). In patients with NASH, there was no correlation between histological grade and the visceral fat volume. Visceral fat accumulation in patients with stage 3/4 advanced NASH was greater than that in patients with stage 1/2 early NASH (P < 0.05). Conclusions These results suggest that visceral fat accumulation plays a role in steatosis and fibrosis in the pathogenesis and prognosis of NAFLD.</abstract><cop>Japan</cop><pub>Japan : Springer Japan</pub><pmid>21042922</pmid><doi>10.1007/s00535-010-0340-3</doi><tpages>9</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0944-1174 |
| ispartof | Journal of gastroenterology, 2011-01, Vol.46 (1), p.70-78 |
| issn | 0944-1174 1435-5922 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_816530898 |
| source | MEDLINE; SpringerLink Journals - AutoHoldings |
| subjects | Abdominal obesity Abdominal Surgery Adipocytokine Adult Aged Alanine transaminase Alanine Transaminase - blood Analysis Biopsy Blood cholesterol Central obesity Cholesterol, LDL - blood Classification Colorectal Surgery Computed tomography Development and progression Disease Progression Electric Impedance Fatty liver Fatty Liver - pathology Female Fibrosis Gastroenterology Glucose Hepatology Humans Inflammation Inflammation - pathology International Forum Intra-Abdominal Fat - pathology Lipoproteins Low density lipoproteins Male Medical research Medicine Medicine & Public Health Medicine, Experimental metabolic syndrome Middle Aged oxidative stress Prognosis Regression Analysis Retrospective Studies steatosis Surgical Oncology Tomography, X-Ray Computed Triglycerides Triglycerides - blood Type 2 diabetes Young Adult |
| title | pathological role of visceral fat accumulation in steatosis, inflammation, and progression of nonalcoholic fatty liver disease |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-03T13%3A37%3A03IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_proqu&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=pathological%20role%20of%20visceral%20fat%20accumulation%20in%20steatosis,%20inflammation,%20and%20progression%20of%20nonalcoholic%20fatty%20liver%20disease&rft.jtitle=Journal%20of%20gastroenterology&rft.au=Eguchi,%20Yuichiro&rft.date=2011-01-01&rft.volume=46&rft.issue=1&rft.spage=70&rft.epage=78&rft.pages=70-78&rft.issn=0944-1174&rft.eissn=1435-5922&rft_id=info:doi/10.1007/s00535-010-0340-3&rft_dat=%3Cgale_proqu%3EA714586131%3C/gale_proqu%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=814356459&rft_id=info:pmid/21042922&rft_galeid=A714586131&rfr_iscdi=true |