Nuclear factor‐κB activation predicts an unfavourable outcome in human upper urinary tract urothelial carcinoma
OBJECTIVE To examine the hypothesis that nuclear factor‐κB (NF‐κB), a transcription factor involved in anti‐apoptosis, invasion, and angiogenesis, plays a role in the carcinogenesis of upper urinary tract urothelial carcinoma (UUT‐UC) and has prognostic value for survival. PATIENTS AND METHODS In al...
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| Veröffentlicht in: | BJU international 2010-10, Vol.106 (8), p.1223-1229 |
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| creator | Yeh, Hsin‐Chih Huang, Chun‐Hsiung Yang, Sheau‐Fang Li, Ching‐Chia Chang, Lin‐Li Lin, Hui‐Hui Ke, Hung‐Lung Wei, Yu‐Ching Wu, Wen‐Jeng |
| description | OBJECTIVE
To examine the hypothesis that nuclear factor‐κB (NF‐κB), a transcription factor involved in anti‐apoptosis, invasion, and angiogenesis, plays a role in the carcinogenesis of upper urinary tract urothelial carcinoma (UUT‐UC) and has prognostic value for survival.
PATIENTS AND METHODS
In all, 90 patients with UUT‐UC [mean (range) age, 64.5 (24–84) years] who underwent surgery at our institution from January 1991 to December 2005 were included. Clinicopathological data were collected retrospectively. We performed immunohistochemical staining for NF‐κB (p65) on paraffin‐embedded sections of the tumour and corresponding normal tissues. The association between survival and potential prognostic factors was examined.
RESULTS
The median follow‐up was 40 months. In all, 55 patients (61.1%) with UUT‐UC overexpressed cytoplasmic NF‐κB, and nuclear immunoreactivity for NF‐κB was detected in 24 patients (26.7%). On univariate analysis, significant prognostic factors for survival were tumour location, stage, grade, lymph node involvement, and nuclear NF‐κB expression. On multivariate analysis, nuclear NF‐κB positivity was an independent predictor for disease‐specific survival [Cox regression hazard ratio (HR) 2.87; P= 0.025] and overall survival (HR 2.24; P= 0.037).
CONCLUSION
These results imply a role for nuclear NF‐κB expression in the tumorigenesis of UUT‐UC. Nuclear NF‐κB may serve as a useful independent molecular marker to predict outcome and may represent a promising therapeutic target for patients with UUT‐UC. |
| doi_str_mv | 10.1111/j.1464-410X.2010.09210.x |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_816530164</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>816530164</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3980-987df0aea5d54d188c066029e591713e9ad9f6adb6681f919877861895db5e333</originalsourceid><addsrcrecordid>eNqNkE9u1TAQxi1ERUvhCsgbxOq92nHi2AsWtOJPUVU2VGJnzXMmqp-cONhxaXccgfNwCA7BSXB4r2WLF_bnmd_M2B8hlLM1L-tku-a1rFc1Z1_WFStRpquy3z4iRw-Jx_eaaXlInqa0ZawEZPOEHJYaUXEtj0i8zNYjRNqDnUP8_f3Hr5-ntGh3A7MLI50ids7OicJI89jDTcgRNh5pyLMNA1I30us8LNlpwkhzdCPEOzrH0qTcwnyN3oGnFqJ1YxjgGTnowSd8vj-PydW7t5_PPqwuPr0_P3tzsbJCK7bSqu16BghN19QdV8oyKVmlsdG85QI1dLqX0G2kVLzXvPCtklzppts0KIQ4Jq92facYvmZMsxlcsug9jBhyMorLRjAu60KqHWljSClib6bohvILw5lZDDdbs3hpFl_NYrj5a7i5LaUv9kPyZsDuofDe4QK83AOQLPg-wmhd-seJSrWSt4V7veO-OY93__0Ac_rxalHiD9ClnzY</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>816530164</pqid></control><display><type>article</type><title>Nuclear factor‐κB activation predicts an unfavourable outcome in human upper urinary tract urothelial carcinoma</title><source>MEDLINE</source><source>Wiley Online Library All Journals</source><creator>Yeh, Hsin‐Chih ; Huang, Chun‐Hsiung ; Yang, Sheau‐Fang ; Li, Ching‐Chia ; Chang, Lin‐Li ; Lin, Hui‐Hui ; Ke, Hung‐Lung ; Wei, Yu‐Ching ; Wu, Wen‐Jeng</creator><creatorcontrib>Yeh, Hsin‐Chih ; Huang, Chun‐Hsiung ; Yang, Sheau‐Fang ; Li, Ching‐Chia ; Chang, Lin‐Li ; Lin, Hui‐Hui ; Ke, Hung‐Lung ; Wei, Yu‐Ching ; Wu, Wen‐Jeng</creatorcontrib><description>OBJECTIVE
To examine the hypothesis that nuclear factor‐κB (NF‐κB), a transcription factor involved in anti‐apoptosis, invasion, and angiogenesis, plays a role in the carcinogenesis of upper urinary tract urothelial carcinoma (UUT‐UC) and has prognostic value for survival.
PATIENTS AND METHODS
In all, 90 patients with UUT‐UC [mean (range) age, 64.5 (24–84) years] who underwent surgery at our institution from January 1991 to December 2005 were included. Clinicopathological data were collected retrospectively. We performed immunohistochemical staining for NF‐κB (p65) on paraffin‐embedded sections of the tumour and corresponding normal tissues. The association between survival and potential prognostic factors was examined.
RESULTS
The median follow‐up was 40 months. In all, 55 patients (61.1%) with UUT‐UC overexpressed cytoplasmic NF‐κB, and nuclear immunoreactivity for NF‐κB was detected in 24 patients (26.7%). On univariate analysis, significant prognostic factors for survival were tumour location, stage, grade, lymph node involvement, and nuclear NF‐κB expression. On multivariate analysis, nuclear NF‐κB positivity was an independent predictor for disease‐specific survival [Cox regression hazard ratio (HR) 2.87; P= 0.025] and overall survival (HR 2.24; P= 0.037).
CONCLUSION
These results imply a role for nuclear NF‐κB expression in the tumorigenesis of UUT‐UC. Nuclear NF‐κB may serve as a useful independent molecular marker to predict outcome and may represent a promising therapeutic target for patients with UUT‐UC.</description><identifier>ISSN: 1464-4096</identifier><identifier>EISSN: 1464-410X</identifier><identifier>DOI: 10.1111/j.1464-410X.2010.09210.x</identifier><identifier>PMID: 20132196</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Adult ; Aged ; Aged, 80 and over ; Biological and medical sciences ; Biomarkers, Tumor - metabolism ; Female ; Humans ; immunohistochemistry ; Kidney Neoplasms - metabolism ; Kidney Neoplasms - pathology ; Kidney Neoplasms - surgery ; Kidney Pelvis ; Male ; Medical sciences ; Middle Aged ; Multivariate Analysis ; Nephrology. Urinary tract diseases ; NF-kappa B - metabolism ; NF‐κB ; p65 ; Prognosis ; Retrospective Studies ; Survival Analysis ; Tumors of the urinary system ; upper urinary tract ; Ureteral Neoplasms - metabolism ; Ureteral Neoplasms - pathology ; Ureteral Neoplasms - surgery ; Urinary system involvement in other diseases. Miscellaneous ; Urinary tract. Prostate gland ; urothelial carcinoma ; Young Adult</subject><ispartof>BJU international, 2010-10, Vol.106 (8), p.1223-1229</ispartof><rights>2010 THE AUTHORS. JOURNAL COMPILATION © 2010 BJU INTERNATIONAL</rights><rights>2015 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3980-987df0aea5d54d188c066029e591713e9ad9f6adb6681f919877861895db5e333</citedby><cites>FETCH-LOGICAL-c3980-987df0aea5d54d188c066029e591713e9ad9f6adb6681f919877861895db5e333</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1464-410X.2010.09210.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1464-410X.2010.09210.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27923,27924,45573,45574</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=23287617$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20132196$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Yeh, Hsin‐Chih</creatorcontrib><creatorcontrib>Huang, Chun‐Hsiung</creatorcontrib><creatorcontrib>Yang, Sheau‐Fang</creatorcontrib><creatorcontrib>Li, Ching‐Chia</creatorcontrib><creatorcontrib>Chang, Lin‐Li</creatorcontrib><creatorcontrib>Lin, Hui‐Hui</creatorcontrib><creatorcontrib>Ke, Hung‐Lung</creatorcontrib><creatorcontrib>Wei, Yu‐Ching</creatorcontrib><creatorcontrib>Wu, Wen‐Jeng</creatorcontrib><title>Nuclear factor‐κB activation predicts an unfavourable outcome in human upper urinary tract urothelial carcinoma</title><title>BJU international</title><addtitle>BJU Int</addtitle><description>OBJECTIVE
To examine the hypothesis that nuclear factor‐κB (NF‐κB), a transcription factor involved in anti‐apoptosis, invasion, and angiogenesis, plays a role in the carcinogenesis of upper urinary tract urothelial carcinoma (UUT‐UC) and has prognostic value for survival.
PATIENTS AND METHODS
In all, 90 patients with UUT‐UC [mean (range) age, 64.5 (24–84) years] who underwent surgery at our institution from January 1991 to December 2005 were included. Clinicopathological data were collected retrospectively. We performed immunohistochemical staining for NF‐κB (p65) on paraffin‐embedded sections of the tumour and corresponding normal tissues. The association between survival and potential prognostic factors was examined.
RESULTS
The median follow‐up was 40 months. In all, 55 patients (61.1%) with UUT‐UC overexpressed cytoplasmic NF‐κB, and nuclear immunoreactivity for NF‐κB was detected in 24 patients (26.7%). On univariate analysis, significant prognostic factors for survival were tumour location, stage, grade, lymph node involvement, and nuclear NF‐κB expression. On multivariate analysis, nuclear NF‐κB positivity was an independent predictor for disease‐specific survival [Cox regression hazard ratio (HR) 2.87; P= 0.025] and overall survival (HR 2.24; P= 0.037).
CONCLUSION
These results imply a role for nuclear NF‐κB expression in the tumorigenesis of UUT‐UC. Nuclear NF‐κB may serve as a useful independent molecular marker to predict outcome and may represent a promising therapeutic target for patients with UUT‐UC.</description><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Biological and medical sciences</subject><subject>Biomarkers, Tumor - metabolism</subject><subject>Female</subject><subject>Humans</subject><subject>immunohistochemistry</subject><subject>Kidney Neoplasms - metabolism</subject><subject>Kidney Neoplasms - pathology</subject><subject>Kidney Neoplasms - surgery</subject><subject>Kidney Pelvis</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Multivariate Analysis</subject><subject>Nephrology. Urinary tract diseases</subject><subject>NF-kappa B - metabolism</subject><subject>NF‐κB</subject><subject>p65</subject><subject>Prognosis</subject><subject>Retrospective Studies</subject><subject>Survival Analysis</subject><subject>Tumors of the urinary system</subject><subject>upper urinary tract</subject><subject>Ureteral Neoplasms - metabolism</subject><subject>Ureteral Neoplasms - pathology</subject><subject>Ureteral Neoplasms - surgery</subject><subject>Urinary system involvement in other diseases. Miscellaneous</subject><subject>Urinary tract. Prostate gland</subject><subject>urothelial carcinoma</subject><subject>Young Adult</subject><issn>1464-4096</issn><issn>1464-410X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkE9u1TAQxi1ERUvhCsgbxOq92nHi2AsWtOJPUVU2VGJnzXMmqp-cONhxaXccgfNwCA7BSXB4r2WLF_bnmd_M2B8hlLM1L-tku-a1rFc1Z1_WFStRpquy3z4iRw-Jx_eaaXlInqa0ZawEZPOEHJYaUXEtj0i8zNYjRNqDnUP8_f3Hr5-ntGh3A7MLI50ids7OicJI89jDTcgRNh5pyLMNA1I30us8LNlpwkhzdCPEOzrH0qTcwnyN3oGnFqJ1YxjgGTnowSd8vj-PydW7t5_PPqwuPr0_P3tzsbJCK7bSqu16BghN19QdV8oyKVmlsdG85QI1dLqX0G2kVLzXvPCtklzppts0KIQ4Jq92facYvmZMsxlcsug9jBhyMorLRjAu60KqHWljSClib6bohvILw5lZDDdbs3hpFl_NYrj5a7i5LaUv9kPyZsDuofDe4QK83AOQLPg-wmhd-seJSrWSt4V7veO-OY93__0Ac_rxalHiD9ClnzY</recordid><startdate>201010</startdate><enddate>201010</enddate><creator>Yeh, Hsin‐Chih</creator><creator>Huang, Chun‐Hsiung</creator><creator>Yang, Sheau‐Fang</creator><creator>Li, Ching‐Chia</creator><creator>Chang, Lin‐Li</creator><creator>Lin, Hui‐Hui</creator><creator>Ke, Hung‐Lung</creator><creator>Wei, Yu‐Ching</creator><creator>Wu, Wen‐Jeng</creator><general>Blackwell Publishing Ltd</general><general>Wiley-Blackwell</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201010</creationdate><title>Nuclear factor‐κB activation predicts an unfavourable outcome in human upper urinary tract urothelial carcinoma</title><author>Yeh, Hsin‐Chih ; Huang, Chun‐Hsiung ; Yang, Sheau‐Fang ; Li, Ching‐Chia ; Chang, Lin‐Li ; Lin, Hui‐Hui ; Ke, Hung‐Lung ; Wei, Yu‐Ching ; Wu, Wen‐Jeng</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3980-987df0aea5d54d188c066029e591713e9ad9f6adb6681f919877861895db5e333</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Biological and medical sciences</topic><topic>Biomarkers, Tumor - metabolism</topic><topic>Female</topic><topic>Humans</topic><topic>immunohistochemistry</topic><topic>Kidney Neoplasms - metabolism</topic><topic>Kidney Neoplasms - pathology</topic><topic>Kidney Neoplasms - surgery</topic><topic>Kidney Pelvis</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Multivariate Analysis</topic><topic>Nephrology. Urinary tract diseases</topic><topic>NF-kappa B - metabolism</topic><topic>NF‐κB</topic><topic>p65</topic><topic>Prognosis</topic><topic>Retrospective Studies</topic><topic>Survival Analysis</topic><topic>Tumors of the urinary system</topic><topic>upper urinary tract</topic><topic>Ureteral Neoplasms - metabolism</topic><topic>Ureteral Neoplasms - pathology</topic><topic>Ureteral Neoplasms - surgery</topic><topic>Urinary system involvement in other diseases. Miscellaneous</topic><topic>Urinary tract. Prostate gland</topic><topic>urothelial carcinoma</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yeh, Hsin‐Chih</creatorcontrib><creatorcontrib>Huang, Chun‐Hsiung</creatorcontrib><creatorcontrib>Yang, Sheau‐Fang</creatorcontrib><creatorcontrib>Li, Ching‐Chia</creatorcontrib><creatorcontrib>Chang, Lin‐Li</creatorcontrib><creatorcontrib>Lin, Hui‐Hui</creatorcontrib><creatorcontrib>Ke, Hung‐Lung</creatorcontrib><creatorcontrib>Wei, Yu‐Ching</creatorcontrib><creatorcontrib>Wu, Wen‐Jeng</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>BJU international</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yeh, Hsin‐Chih</au><au>Huang, Chun‐Hsiung</au><au>Yang, Sheau‐Fang</au><au>Li, Ching‐Chia</au><au>Chang, Lin‐Li</au><au>Lin, Hui‐Hui</au><au>Ke, Hung‐Lung</au><au>Wei, Yu‐Ching</au><au>Wu, Wen‐Jeng</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Nuclear factor‐κB activation predicts an unfavourable outcome in human upper urinary tract urothelial carcinoma</atitle><jtitle>BJU international</jtitle><addtitle>BJU Int</addtitle><date>2010-10</date><risdate>2010</risdate><volume>106</volume><issue>8</issue><spage>1223</spage><epage>1229</epage><pages>1223-1229</pages><issn>1464-4096</issn><eissn>1464-410X</eissn><abstract>OBJECTIVE
To examine the hypothesis that nuclear factor‐κB (NF‐κB), a transcription factor involved in anti‐apoptosis, invasion, and angiogenesis, plays a role in the carcinogenesis of upper urinary tract urothelial carcinoma (UUT‐UC) and has prognostic value for survival.
PATIENTS AND METHODS
In all, 90 patients with UUT‐UC [mean (range) age, 64.5 (24–84) years] who underwent surgery at our institution from January 1991 to December 2005 were included. Clinicopathological data were collected retrospectively. We performed immunohistochemical staining for NF‐κB (p65) on paraffin‐embedded sections of the tumour and corresponding normal tissues. The association between survival and potential prognostic factors was examined.
RESULTS
The median follow‐up was 40 months. In all, 55 patients (61.1%) with UUT‐UC overexpressed cytoplasmic NF‐κB, and nuclear immunoreactivity for NF‐κB was detected in 24 patients (26.7%). On univariate analysis, significant prognostic factors for survival were tumour location, stage, grade, lymph node involvement, and nuclear NF‐κB expression. On multivariate analysis, nuclear NF‐κB positivity was an independent predictor for disease‐specific survival [Cox regression hazard ratio (HR) 2.87; P= 0.025] and overall survival (HR 2.24; P= 0.037).
CONCLUSION
These results imply a role for nuclear NF‐κB expression in the tumorigenesis of UUT‐UC. Nuclear NF‐κB may serve as a useful independent molecular marker to predict outcome and may represent a promising therapeutic target for patients with UUT‐UC.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>20132196</pmid><doi>10.1111/j.1464-410X.2010.09210.x</doi><tpages>7</tpages></addata></record> |
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| subjects | Adult Aged Aged, 80 and over Biological and medical sciences Biomarkers, Tumor - metabolism Female Humans immunohistochemistry Kidney Neoplasms - metabolism Kidney Neoplasms - pathology Kidney Neoplasms - surgery Kidney Pelvis Male Medical sciences Middle Aged Multivariate Analysis Nephrology. Urinary tract diseases NF-kappa B - metabolism NF‐κB p65 Prognosis Retrospective Studies Survival Analysis Tumors of the urinary system upper urinary tract Ureteral Neoplasms - metabolism Ureteral Neoplasms - pathology Ureteral Neoplasms - surgery Urinary system involvement in other diseases. Miscellaneous Urinary tract. Prostate gland urothelial carcinoma Young Adult |
| title | Nuclear factor‐κB activation predicts an unfavourable outcome in human upper urinary tract urothelial carcinoma |
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