Altered aquaporin expression and role in apoptosis during hepatic stellate cell activation

Background: Hepatic stellate cells (HSCs) are effector cells of hepatic fibrosis contributing to excessive collagen deposition and scar matrix formation. Sustained HSC activation leads to hepatic cirrhosis, a leading cause of liver‐related death. Reversal of hepatic fibrosis has been attributed to t...

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Veröffentlicht in:	Liver international 2011-01, Vol.31 (1), p.42-51
Hauptverfasser:	Lakner, Ashley M., Walling, Tracy L., McKillop, Iain H., Schrum, Laura W.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals apoptosis Apoptosis - drug effects aquaporin Aquaporins - antagonists & inhibitors Aquaporins - genetics Aquaporins - metabolism Blotting, Western Cell Membrane Permeability Cell Shape Cells, Cultured fibrosis Fluorescent Antibody Technique Gene Expression Regulation hepatic stellate cell Hepatic Stellate Cells - drug effects Hepatic Stellate Cells - metabolism Hepatic Stellate Cells - pathology Male Mercuric Chloride Osmosis Rats Rats, Sprague-Dawley Reverse Transcriptase Polymerase Chain Reaction RNA, Messenger - metabolism Time Factors transdifferentiation Water - metabolism
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