Expression of Endothelin‐1 and Endothelin Receptor A in Canine Ovarian Tumours
Ovarian tumours have a low incidence in bitch. Endothelin (ET‐1) and endothelin A receptor (ET‐A) are overexpressed in human ovarian cancer. Twenty canine ovarian tumours and five normal samples were first evaluated by western blotting and then immunohistochemically for ET‐1 and ET‐A expression. Sev...
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| Veröffentlicht in: | Reproduction in domestic animals 2010-12, Vol.45 (6), p.e465-e468 |
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| container_title | Reproduction in domestic animals |
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| creator | Borzacchiello, G Mogavero, S Tortorella, G Catone, G Russo, M |
| description | Ovarian tumours have a low incidence in bitch. Endothelin (ET‐1) and endothelin A receptor (ET‐A) are overexpressed in human ovarian cancer. Twenty canine ovarian tumours and five normal samples were first evaluated by western blotting and then immunohistochemically for ET‐1 and ET‐A expression. Seventeen out of twenty tumours were ET‐1 positive. Eight out of twenty tumours were ET‐A immunohistochemically positive. At molecular level both proteins were proven to be expressed in normal as well as in tumour samples. Our results show that ET‐1 and ET‐A are overexpressed in canine ovarian tumours, suggesting a potential role of these two molecules in canine ovarian carcinogenesis. |
| doi_str_mv | 10.1111/j.1439-0531.2010.01580.x |
| format | Article |
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Endothelin (ET‐1) and endothelin A receptor (ET‐A) are overexpressed in human ovarian cancer. Twenty canine ovarian tumours and five normal samples were first evaluated by western blotting and then immunohistochemically for ET‐1 and ET‐A expression. Seventeen out of twenty tumours were ET‐1 positive. Eight out of twenty tumours were ET‐A immunohistochemically positive. At molecular level both proteins were proven to be expressed in normal as well as in tumour samples. Our results show that ET‐1 and ET‐A are overexpressed in canine ovarian tumours, suggesting a potential role of these two molecules in canine ovarian carcinogenesis.</description><identifier>ISSN: 0936-6768</identifier><identifier>EISSN: 1439-0531</identifier><identifier>DOI: 10.1111/j.1439-0531.2010.01580.x</identifier><identifier>PMID: 20210880</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Animals ; Carcinoma, Papillary - metabolism ; Carcinoma, Papillary - veterinary ; Cystadenocarcinoma - metabolism ; Cystadenocarcinoma - veterinary ; Dog Diseases - metabolism ; Dogs ; Endothelin-1 - genetics ; Endothelin-1 - metabolism ; Female ; Gene Expression Regulation, Neoplastic - physiology ; Genes ; Granulosa Cell Tumor - metabolism ; Granulosa Cell Tumor - veterinary ; Neurons ; Ovarian cancer ; Ovarian Neoplasms - metabolism ; Ovarian Neoplasms - veterinary ; Receptor, Endothelin A - genetics ; Receptor, Endothelin A - metabolism ; Tumors</subject><ispartof>Reproduction in domestic animals, 2010-12, Vol.45 (6), p.e465-e468</ispartof><rights>2010 Blackwell Verlag GmbH</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4850-6be733bbd29ff355dee74de3bf6f0165628e77aa68d6f31681971a58ce931cf93</citedby><cites>FETCH-LOGICAL-c4850-6be733bbd29ff355dee74de3bf6f0165628e77aa68d6f31681971a58ce931cf93</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1439-0531.2010.01580.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1439-0531.2010.01580.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>315,781,785,1418,27929,27930,45579,45580</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20210880$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Borzacchiello, G</creatorcontrib><creatorcontrib>Mogavero, S</creatorcontrib><creatorcontrib>Tortorella, G</creatorcontrib><creatorcontrib>Catone, G</creatorcontrib><creatorcontrib>Russo, M</creatorcontrib><title>Expression of Endothelin‐1 and Endothelin Receptor A in Canine Ovarian Tumours</title><title>Reproduction in domestic animals</title><addtitle>Reprod Domest Anim</addtitle><description>Ovarian tumours have a low incidence in bitch. Endothelin (ET‐1) and endothelin A receptor (ET‐A) are overexpressed in human ovarian cancer. Twenty canine ovarian tumours and five normal samples were first evaluated by western blotting and then immunohistochemically for ET‐1 and ET‐A expression. Seventeen out of twenty tumours were ET‐1 positive. Eight out of twenty tumours were ET‐A immunohistochemically positive. At molecular level both proteins were proven to be expressed in normal as well as in tumour samples. Our results show that ET‐1 and ET‐A are overexpressed in canine ovarian tumours, suggesting a potential role of these two molecules in canine ovarian carcinogenesis.</description><subject>Animals</subject><subject>Carcinoma, Papillary - metabolism</subject><subject>Carcinoma, Papillary - veterinary</subject><subject>Cystadenocarcinoma - metabolism</subject><subject>Cystadenocarcinoma - veterinary</subject><subject>Dog Diseases - metabolism</subject><subject>Dogs</subject><subject>Endothelin-1 - genetics</subject><subject>Endothelin-1 - metabolism</subject><subject>Female</subject><subject>Gene Expression Regulation, Neoplastic - physiology</subject><subject>Genes</subject><subject>Granulosa Cell Tumor - metabolism</subject><subject>Granulosa Cell Tumor - veterinary</subject><subject>Neurons</subject><subject>Ovarian cancer</subject><subject>Ovarian Neoplasms - metabolism</subject><subject>Ovarian Neoplasms - veterinary</subject><subject>Receptor, Endothelin A - genetics</subject><subject>Receptor, Endothelin A - metabolism</subject><subject>Tumors</subject><issn>0936-6768</issn><issn>1439-0531</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkc9u1DAQxi0EokvhFSCCA6cs4zj-kwOH1XYpSC1FpS0Sl5E3GUOWbLLYG9jeeASekSfBIWWFkJCwLHk8_n2fR_oYSzhMeVzPVlOeiyIFKfg0g9gFLg1Md7fYZP9wm02gECpVWpkDdi-EFQyU1nfZQQYZB2Ngwt4sdhtPIdRdm3QuWbRVt_1ITd3--PadJ7at_mgl51TSZtv5ZJbE29y2dUvJ2Rfra9smF_266324z-442wR6cHMesssXi4v5y_Tk7PjVfHaSlrmRkKolaSGWyyornBNSVkQ6r0gsnXLAlVSZIa2tVaZSTnBleKG5laakQvDSFeKQPR19N7773FPY4roOJTWNbanrAxquhNGgIJKP_yJXcdA2DocGdB63GaAn_4K4zmReCAkDZUaq9F0InhxufL22_ho54JAMrnAIAIcAcEgGfyWDuyh9ePNBv1xTtRf-jiICz0fga93Q9X8b4_nRbKiiPh31ddjSbq-3_hMqLbTEd6-P8fTq9EjM4QrfR_7RyDvbof3g64CXb6OzAF5wybUWPwEcG7MQ</recordid><startdate>201012</startdate><enddate>201012</enddate><creator>Borzacchiello, G</creator><creator>Mogavero, S</creator><creator>Tortorella, G</creator><creator>Catone, G</creator><creator>Russo, M</creator><general>Blackwell Publishing Ltd</general><scope>FBQ</scope><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>201012</creationdate><title>Expression of Endothelin‐1 and Endothelin Receptor A in Canine Ovarian Tumours</title><author>Borzacchiello, G ; Mogavero, S ; Tortorella, G ; Catone, G ; Russo, M</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4850-6be733bbd29ff355dee74de3bf6f0165628e77aa68d6f31681971a58ce931cf93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Animals</topic><topic>Carcinoma, Papillary - metabolism</topic><topic>Carcinoma, Papillary - veterinary</topic><topic>Cystadenocarcinoma - metabolism</topic><topic>Cystadenocarcinoma - veterinary</topic><topic>Dog Diseases - metabolism</topic><topic>Dogs</topic><topic>Endothelin-1 - genetics</topic><topic>Endothelin-1 - metabolism</topic><topic>Female</topic><topic>Gene Expression Regulation, Neoplastic - physiology</topic><topic>Genes</topic><topic>Granulosa Cell Tumor - metabolism</topic><topic>Granulosa Cell Tumor - veterinary</topic><topic>Neurons</topic><topic>Ovarian cancer</topic><topic>Ovarian Neoplasms - metabolism</topic><topic>Ovarian Neoplasms - veterinary</topic><topic>Receptor, Endothelin A - genetics</topic><topic>Receptor, Endothelin A - metabolism</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Borzacchiello, G</creatorcontrib><creatorcontrib>Mogavero, S</creatorcontrib><creatorcontrib>Tortorella, G</creatorcontrib><creatorcontrib>Catone, G</creatorcontrib><creatorcontrib>Russo, M</creatorcontrib><collection>AGRIS</collection><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Reproduction in domestic animals</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Borzacchiello, G</au><au>Mogavero, S</au><au>Tortorella, G</au><au>Catone, G</au><au>Russo, M</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Expression of Endothelin‐1 and Endothelin Receptor A in Canine Ovarian Tumours</atitle><jtitle>Reproduction in domestic animals</jtitle><addtitle>Reprod Domest Anim</addtitle><date>2010-12</date><risdate>2010</risdate><volume>45</volume><issue>6</issue><spage>e465</spage><epage>e468</epage><pages>e465-e468</pages><issn>0936-6768</issn><eissn>1439-0531</eissn><abstract>Ovarian tumours have a low incidence in bitch. Endothelin (ET‐1) and endothelin A receptor (ET‐A) are overexpressed in human ovarian cancer. Twenty canine ovarian tumours and five normal samples were first evaluated by western blotting and then immunohistochemically for ET‐1 and ET‐A expression. Seventeen out of twenty tumours were ET‐1 positive. Eight out of twenty tumours were ET‐A immunohistochemically positive. At molecular level both proteins were proven to be expressed in normal as well as in tumour samples. Our results show that ET‐1 and ET‐A are overexpressed in canine ovarian tumours, suggesting a potential role of these two molecules in canine ovarian carcinogenesis.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>20210880</pmid><doi>10.1111/j.1439-0531.2010.01580.x</doi><tpages>4</tpages></addata></record> |
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| subjects | Animals Carcinoma, Papillary - metabolism Carcinoma, Papillary - veterinary Cystadenocarcinoma - metabolism Cystadenocarcinoma - veterinary Dog Diseases - metabolism Dogs Endothelin-1 - genetics Endothelin-1 - metabolism Female Gene Expression Regulation, Neoplastic - physiology Genes Granulosa Cell Tumor - metabolism Granulosa Cell Tumor - veterinary Neurons Ovarian cancer Ovarian Neoplasms - metabolism Ovarian Neoplasms - veterinary Receptor, Endothelin A - genetics Receptor, Endothelin A - metabolism Tumors |
| title | Expression of Endothelin‐1 and Endothelin Receptor A in Canine Ovarian Tumours |
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