Antihyperglycaemic, antilipid peroxidative and antioxidant effects of gallic acid on streptozotocin induced diabetic Wistar rats

The present study aims to evaluate the antihyperglycaemic, antilipid peroxidative and antioxidant effects of gallic acid on streptozotocin induced diabetic male Wistar rats. To induce diabetes mellitus, rats were injected with streptozotocin intraperitoneally at a single dose of 40 mg/kg. Streptozot...

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Veröffentlicht in:	European journal of pharmacology 2011-01, Vol.650 (1), p.465-471
Hauptverfasser:	Punithavathi, Vilapakkam Ranganathan, Prince, Ponnian Stanely Mainzen, Kumar, Ramesh, Selvakumari, Jemmi
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antioxidant antioxidant activity Benzothiazoles - metabolism Biological and medical sciences Blood glucose Blood Glucose - metabolism body weight catalase Diabetes mellitus Diabetes Mellitus, Experimental - drug therapy Diabetes Mellitus, Experimental - metabolism Diabetes Mellitus, Experimental - pathology Diabetes. Impaired glucose tolerance Endocrine pancreas. Apud cells (diseases) Endocrinopathies Etiopathogenesis. Screening. Investigations. Target tissue resistance Free Radical Scavengers - pharmacology Free Radical Scavengers - therapeutic use Gallic acid Gallic Acid - pharmacology Gallic Acid - therapeutic use glucose-6-phosphatase glutathione peroxidase Glycated Hemoglobin A - metabolism glycosylation hemoglobin hexokinase histopathology hydroperoxides Hypoglycemic Agents - pharmacology Hypoglycemic Agents - therapeutic use in vitro studies insulin Insulin - blood Lipid Peroxidation - drug effects Male Medical sciences oral administration Pancreas Pancreas - drug effects Pancreas - metabolism Pancreas - pathology pharmacology Pharmacology. Drug treatments protective effect Rats Rats, Wistar Streptozotocin Sulfonic Acids - metabolism superoxide dismutase thiobarbituric acid-reactive substances
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