Cervical intraepithelial neoplasia: Telomerase activity and splice pattern of hTERT mRNA
Cervical cancers are characterized by the persistence of human papilloma virus (HPV) genome that is found in tissue samples starting from the early stages of tumor progression. Just like in other tumors, the activation of telomerase was observed in cervical carcinomas, but information about its expr...
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| Veröffentlicht in: | Biochimie 2010-12, Vol.92 (12), p.1827-1831 |
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| creator | Petrenko, A.A. Korolenkova, L.I. Skvortsov, D.A. Fedorova, M.D. Skoblov, M.U. Baranova, A.V. Zvereva, M.E. Rubtsova, M.P. Kisseljov, F.L. |
| description | Cervical cancers are characterized by the persistence of human papilloma virus (HPV) genome that is found in tissue samples starting from the early stages of tumor progression. Just like in other tumors, the activation of telomerase was observed in cervical carcinomas, but information about its expression was controversial. The aim of this study is to find possible correlations between the presence of HPV sequences, activity of telomerase and expression of different spliced forms of hTERT RNA in cervical intraepithelial neoplasias (CIN). The results show that HPV DNA is present in 60% of normal tissue adjacent to CIN lesions and up to 84% in CIN samples. Telomerase activity was found in 28% of adjacent normal tissue and in 68% of CIN II–III. hTERT RNA that encodes an active enzyme was present almost in all CIN samples. Variations in levels of telomerase activity are possibly not regulated by the splicing forms of hTERT mRNA with deletions. |
| doi_str_mv | 10.1016/j.biochi.2010.07.015 |
| format | Article |
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Just like in other tumors, the activation of telomerase was observed in cervical carcinomas, but information about its expression was controversial. The aim of this study is to find possible correlations between the presence of HPV sequences, activity of telomerase and expression of different spliced forms of hTERT RNA in cervical intraepithelial neoplasias (CIN). The results show that HPV DNA is present in 60% of normal tissue adjacent to CIN lesions and up to 84% in CIN samples. Telomerase activity was found in 28% of adjacent normal tissue and in 68% of CIN II–III. hTERT RNA that encodes an active enzyme was present almost in all CIN samples. Variations in levels of telomerase activity are possibly not regulated by the splicing forms of hTERT mRNA with deletions.</description><identifier>ISSN: 0300-9084</identifier><identifier>EISSN: 1638-6183</identifier><identifier>DOI: 10.1016/j.biochi.2010.07.015</identifier><identifier>PMID: 20691751</identifier><language>eng</language><publisher>France: Elsevier Masson SAS</publisher><subject>Cervical intraepithelial neoplasia ; Cervical Intraepithelial Neoplasia - enzymology ; Cervical Intraepithelial Neoplasia - genetics ; Cervical Intraepithelial Neoplasia - virology ; DNA, Viral - genetics ; Female ; Host-Pathogen Interactions ; HPV ; Human papillomavirus 16 - genetics ; Human papillomavirus 16 - physiology ; Humans ; Papillomavirus Infections - virology ; Reverse Transcriptase Polymerase Chain Reaction ; RNA Splicing ; RNA, Messenger - genetics ; RNA, Messenger - metabolism ; Telomerase ; Telomerase - genetics ; Telomerase - metabolism ; Uterine Cervical Neoplasms - enzymology ; Uterine Cervical Neoplasms - genetics ; Uterine Cervical Neoplasms - virology</subject><ispartof>Biochimie, 2010-12, Vol.92 (12), p.1827-1831</ispartof><rights>2010</rights><rights>Copyright © 2010. 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Just like in other tumors, the activation of telomerase was observed in cervical carcinomas, but information about its expression was controversial. The aim of this study is to find possible correlations between the presence of HPV sequences, activity of telomerase and expression of different spliced forms of hTERT RNA in cervical intraepithelial neoplasias (CIN). The results show that HPV DNA is present in 60% of normal tissue adjacent to CIN lesions and up to 84% in CIN samples. Telomerase activity was found in 28% of adjacent normal tissue and in 68% of CIN II–III. hTERT RNA that encodes an active enzyme was present almost in all CIN samples. Variations in levels of telomerase activity are possibly not regulated by the splicing forms of hTERT mRNA with deletions.</description><subject>Cervical intraepithelial neoplasia</subject><subject>Cervical Intraepithelial Neoplasia - enzymology</subject><subject>Cervical Intraepithelial Neoplasia - genetics</subject><subject>Cervical Intraepithelial Neoplasia - virology</subject><subject>DNA, Viral - genetics</subject><subject>Female</subject><subject>Host-Pathogen Interactions</subject><subject>HPV</subject><subject>Human papillomavirus 16 - genetics</subject><subject>Human papillomavirus 16 - physiology</subject><subject>Humans</subject><subject>Papillomavirus Infections - virology</subject><subject>Reverse Transcriptase Polymerase Chain Reaction</subject><subject>RNA Splicing</subject><subject>RNA, Messenger - genetics</subject><subject>RNA, Messenger - metabolism</subject><subject>Telomerase</subject><subject>Telomerase - genetics</subject><subject>Telomerase - metabolism</subject><subject>Uterine Cervical Neoplasms - enzymology</subject><subject>Uterine Cervical Neoplasms - genetics</subject><subject>Uterine Cervical Neoplasms - virology</subject><issn>0300-9084</issn><issn>1638-6183</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kEtLAzEQgIMotj7-gUhunrZOdrO7WQ9CKfUBoiAVvIVsMktT9mWSFvz37tLq0dM8-GaG-Qi5YjBjwLLbzay0nV7bWQxDC_IZsPSITFmWiChjIjkmU0gAogIEn5Az7zcAkEJcnJJJDFnB8pRNyecC3c5qVVPbBqewt2GNtR3qFru-Vt6qO7rCumvQKY9U6WB3NnxT1Rrq-9pqpL0KAV1Lu4quV8v3FW3eX-cX5KRStcfLQzwnHw_L1eIpenl7fF7MXyLNExYikXPgRVUwhSxOEw6CmTI2JWcGFOaoC8G4MqXI1Jhxkya6qMwAZshKIZJzcrPf27vua4s-yMZ6jXWthge2XopRSJbmI8n3pHad9w4r2TvbKPctGchRqdzIvVI5KpWQy0HpMHZ9OLAtGzR_Q78OB-B-D-Dw5s6ik15bbDUa61AHaTr7_4Uf3uSJBQ</recordid><startdate>20101201</startdate><enddate>20101201</enddate><creator>Petrenko, A.A.</creator><creator>Korolenkova, L.I.</creator><creator>Skvortsov, D.A.</creator><creator>Fedorova, M.D.</creator><creator>Skoblov, M.U.</creator><creator>Baranova, A.V.</creator><creator>Zvereva, M.E.</creator><creator>Rubtsova, M.P.</creator><creator>Kisseljov, F.L.</creator><general>Elsevier Masson SAS</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20101201</creationdate><title>Cervical intraepithelial neoplasia: Telomerase activity and splice pattern of hTERT mRNA</title><author>Petrenko, A.A. ; Korolenkova, L.I. ; Skvortsov, D.A. ; Fedorova, M.D. ; Skoblov, M.U. ; Baranova, A.V. ; Zvereva, M.E. ; Rubtsova, M.P. ; Kisseljov, F.L.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c431t-874049f91ae12534081db2db41d0ae7ec9814adb86a98144d53c9fd3406e1b883</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Cervical intraepithelial neoplasia</topic><topic>Cervical Intraepithelial Neoplasia - enzymology</topic><topic>Cervical Intraepithelial Neoplasia - genetics</topic><topic>Cervical Intraepithelial Neoplasia - virology</topic><topic>DNA, Viral - genetics</topic><topic>Female</topic><topic>Host-Pathogen Interactions</topic><topic>HPV</topic><topic>Human papillomavirus 16 - genetics</topic><topic>Human papillomavirus 16 - physiology</topic><topic>Humans</topic><topic>Papillomavirus Infections - virology</topic><topic>Reverse Transcriptase Polymerase Chain Reaction</topic><topic>RNA Splicing</topic><topic>RNA, Messenger - genetics</topic><topic>RNA, Messenger - metabolism</topic><topic>Telomerase</topic><topic>Telomerase - genetics</topic><topic>Telomerase - metabolism</topic><topic>Uterine Cervical Neoplasms - enzymology</topic><topic>Uterine Cervical Neoplasms - genetics</topic><topic>Uterine Cervical Neoplasms - virology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Petrenko, A.A.</creatorcontrib><creatorcontrib>Korolenkova, L.I.</creatorcontrib><creatorcontrib>Skvortsov, D.A.</creatorcontrib><creatorcontrib>Fedorova, M.D.</creatorcontrib><creatorcontrib>Skoblov, M.U.</creatorcontrib><creatorcontrib>Baranova, A.V.</creatorcontrib><creatorcontrib>Zvereva, M.E.</creatorcontrib><creatorcontrib>Rubtsova, M.P.</creatorcontrib><creatorcontrib>Kisseljov, F.L.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Biochimie</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Petrenko, A.A.</au><au>Korolenkova, L.I.</au><au>Skvortsov, D.A.</au><au>Fedorova, M.D.</au><au>Skoblov, M.U.</au><au>Baranova, A.V.</au><au>Zvereva, M.E.</au><au>Rubtsova, M.P.</au><au>Kisseljov, F.L.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Cervical intraepithelial neoplasia: Telomerase activity and splice pattern of hTERT mRNA</atitle><jtitle>Biochimie</jtitle><addtitle>Biochimie</addtitle><date>2010-12-01</date><risdate>2010</risdate><volume>92</volume><issue>12</issue><spage>1827</spage><epage>1831</epage><pages>1827-1831</pages><issn>0300-9084</issn><eissn>1638-6183</eissn><abstract>Cervical cancers are characterized by the persistence of human papilloma virus (HPV) genome that is found in tissue samples starting from the early stages of tumor progression. Just like in other tumors, the activation of telomerase was observed in cervical carcinomas, but information about its expression was controversial. The aim of this study is to find possible correlations between the presence of HPV sequences, activity of telomerase and expression of different spliced forms of hTERT RNA in cervical intraepithelial neoplasias (CIN). The results show that HPV DNA is present in 60% of normal tissue adjacent to CIN lesions and up to 84% in CIN samples. Telomerase activity was found in 28% of adjacent normal tissue and in 68% of CIN II–III. hTERT RNA that encodes an active enzyme was present almost in all CIN samples. Variations in levels of telomerase activity are possibly not regulated by the splicing forms of hTERT mRNA with deletions.</abstract><cop>France</cop><pub>Elsevier Masson SAS</pub><pmid>20691751</pmid><doi>10.1016/j.biochi.2010.07.015</doi><tpages>5</tpages></addata></record> |
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| subjects | Cervical intraepithelial neoplasia Cervical Intraepithelial Neoplasia - enzymology Cervical Intraepithelial Neoplasia - genetics Cervical Intraepithelial Neoplasia - virology DNA, Viral - genetics Female Host-Pathogen Interactions HPV Human papillomavirus 16 - genetics Human papillomavirus 16 - physiology Humans Papillomavirus Infections - virology Reverse Transcriptase Polymerase Chain Reaction RNA Splicing RNA, Messenger - genetics RNA, Messenger - metabolism Telomerase Telomerase - genetics Telomerase - metabolism Uterine Cervical Neoplasms - enzymology Uterine Cervical Neoplasms - genetics Uterine Cervical Neoplasms - virology |
| title | Cervical intraepithelial neoplasia: Telomerase activity and splice pattern of hTERT mRNA |
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