Improvement in smell and taste dysfunction after repetitive transcranial magnetic stimulation
Abstract Background Olfactory and gustatory distortions in the absence of odors or tastants (phantosmia and phantageusia, respectively) with accompanying loss of smell and taste acuity are relatively common symptoms that can occur without other otolaryngologic symptoms. Although treatment of these s...
Gespeichert in:
| Veröffentlicht in: | American journal of otolaryngology 2011, Vol.32 (1), p.38-46 |
|---|---|
| Hauptverfasser: | , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 46 |
|---|---|
| container_issue | 1 |
| container_start_page | 38 |
| container_title | American journal of otolaryngology |
| container_volume | 32 |
| creator | Henkin, Robert I., MD, PhD Potolicchio, Samuel J., MD Levy, Lucien M., MD, PhD |
| description | Abstract Background Olfactory and gustatory distortions in the absence of odors or tastants (phantosmia and phantageusia, respectively) with accompanying loss of smell and taste acuity are relatively common symptoms that can occur without other otolaryngologic symptoms. Although treatment of these symptoms has been elusive, repetitive transcranial magnetic stimulation (rTMS) has been suggested as an effective corrective therapy. Objective The objective of the study was to assess the efficacy of rTMS treatment in patients with phantosmia and phantageusia. Methods Seventeen patients with symptoms of persistent phantosmia and phantageusia with accompanying loss of smell and taste acuity were studied. Before and after treatment, patients were monitored by subjective responses and with psychophysical tests of smell function (olfactometry) and taste function (gustometry). Each patient was treated with rTMS that consisted of 2 sham procedures followed by a real rTMS procedure. Results After sham rTMS, no change in measurements of distortions or acuity occurred in any patient; after initial real rTMS, 2 patients received no benefit; but in the other 15, distortions decreased and acuity increased. Two of these 15 exhibited total inhibition of distortions and return of normal sensory acuity that persisted for over 5 years of follow-up. In the other 13, inhibition of distortions and improvement in sensory acuity gradually decreased; but repeated rTMS again inhibited their distortions and improved their acuity. Eighty-eight percent of patients responded to this therapeutic method, although repeated rTMS was necessary to induce these positive changes. Interpretation These results suggest that rTMS is a potential future therapeutic option to treat patients with the relatively common problems of persistent phantosmia and phantageusia with accompanying loss of taste and smell acuity. Additional systematic studies are necessary to confirm these results. |
| doi_str_mv | 10.1016/j.amjoto.2009.10.001 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_816385814</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0196070909002208</els_id><sourcerecordid>2730050181</sourcerecordid><originalsourceid>FETCH-LOGICAL-c474t-5f870aec2d08885e4d24af8ade88e4391ac663756f0409351ae8441fc8b763103</originalsourceid><addsrcrecordid>eNqFkl2L1DAUhoMo7rj6D0QCIl7NePLRNr0RZPFjYcELFbyRkE1PJbVNxyQdmH_vKTO6sDcSSODkOW_e8xLGngvYCRD1m2HnpmEu804CtFTaAYgHbCMqJbdGmO8P2QZEW2-hgfaCPcl5AAClVfWYXVCLlHWtNuzH9bRP8wEnjIWHyPOE48hd7HhxuSDvjrlfoi9hjtz1BRNPuMcSSjggL8nF7GkLbuST-xnpwvNcwrSMbm15yh71bsz47Hxesm8f3n-9-rS9-fzx-urdzdbrRpdt1ZsGHHrZgTGmQt1J7XrjOjQGtWqF82S2qeoeNLSqEg6N1qL35raplQB1yV6fdGmW3wvmYqeQPU3iIs5LtkbUylRGaCJf3iOHeUmRzFnSEVpCVUmi9Inyac45YW_3KUwuHQmya_p2sKf07Zr-WqX0qe3FWXy5nbD71_Q3bgJenQGXvRt7is6HfMepptWyXoXenjik0A4Bk80-YPTYhYS-2G4O_3NyX8CPIQZ68xceMd_NbLO0YL-sP2X9KLTIKhj1B51EudY</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1031420552</pqid></control><display><type>article</type><title>Improvement in smell and taste dysfunction after repetitive transcranial magnetic stimulation</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals</source><creator>Henkin, Robert I., MD, PhD ; Potolicchio, Samuel J., MD ; Levy, Lucien M., MD, PhD</creator><creatorcontrib>Henkin, Robert I., MD, PhD ; Potolicchio, Samuel J., MD ; Levy, Lucien M., MD, PhD</creatorcontrib><description>Abstract Background Olfactory and gustatory distortions in the absence of odors or tastants (phantosmia and phantageusia, respectively) with accompanying loss of smell and taste acuity are relatively common symptoms that can occur without other otolaryngologic symptoms. Although treatment of these symptoms has been elusive, repetitive transcranial magnetic stimulation (rTMS) has been suggested as an effective corrective therapy. Objective The objective of the study was to assess the efficacy of rTMS treatment in patients with phantosmia and phantageusia. Methods Seventeen patients with symptoms of persistent phantosmia and phantageusia with accompanying loss of smell and taste acuity were studied. Before and after treatment, patients were monitored by subjective responses and with psychophysical tests of smell function (olfactometry) and taste function (gustometry). Each patient was treated with rTMS that consisted of 2 sham procedures followed by a real rTMS procedure. Results After sham rTMS, no change in measurements of distortions or acuity occurred in any patient; after initial real rTMS, 2 patients received no benefit; but in the other 15, distortions decreased and acuity increased. Two of these 15 exhibited total inhibition of distortions and return of normal sensory acuity that persisted for over 5 years of follow-up. In the other 13, inhibition of distortions and improvement in sensory acuity gradually decreased; but repeated rTMS again inhibited their distortions and improved their acuity. Eighty-eight percent of patients responded to this therapeutic method, although repeated rTMS was necessary to induce these positive changes. Interpretation These results suggest that rTMS is a potential future therapeutic option to treat patients with the relatively common problems of persistent phantosmia and phantageusia with accompanying loss of taste and smell acuity. Additional systematic studies are necessary to confirm these results.</description><identifier>ISSN: 0196-0709</identifier><identifier>EISSN: 1532-818X</identifier><identifier>DOI: 10.1016/j.amjoto.2009.10.001</identifier><identifier>PMID: 20022663</identifier><identifier>CODEN: AJOTDP</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Adult ; Aged ; Biological and medical sciences ; Brain ; Cranial nerves. Spinal roots. Peripheral nerves. Autonomic nervous system. Gustation. Olfaction ; Dopamine ; Female ; Humans ; Male ; Medical sciences ; Middle Aged ; Nervous system (semeiology, syndromes) ; Neurology ; Neurotransmitters ; Odors ; Olfaction Disorders - physiopathology ; Olfaction Disorders - therapy ; Otolaryngology ; Otorhinolaryngology. Stomatology ; Placebo effect ; Prospective Studies ; Smell ; Surgery ; Taste ; Taste Disorders - physiopathology ; Taste Disorders - therapy ; Transcranial Magnetic Stimulation ; Treatment Outcome</subject><ispartof>American journal of otolaryngology, 2011, Vol.32 (1), p.38-46</ispartof><rights>Elsevier Inc.</rights><rights>2009 Elsevier Inc.</rights><rights>2015 INIST-CNRS</rights><rights>Copyright © 2009 Elsevier Inc. All rights reserved.</rights><rights>2011 Elsevier Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c474t-5f870aec2d08885e4d24af8ade88e4391ac663756f0409351ae8441fc8b763103</citedby><cites>FETCH-LOGICAL-c474t-5f870aec2d08885e4d24af8ade88e4391ac663756f0409351ae8441fc8b763103</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0196070909002208$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3536,4009,27902,27903,27904,65309</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=23794261$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20022663$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Henkin, Robert I., MD, PhD</creatorcontrib><creatorcontrib>Potolicchio, Samuel J., MD</creatorcontrib><creatorcontrib>Levy, Lucien M., MD, PhD</creatorcontrib><title>Improvement in smell and taste dysfunction after repetitive transcranial magnetic stimulation</title><title>American journal of otolaryngology</title><addtitle>Am J Otolaryngol</addtitle><description>Abstract Background Olfactory and gustatory distortions in the absence of odors or tastants (phantosmia and phantageusia, respectively) with accompanying loss of smell and taste acuity are relatively common symptoms that can occur without other otolaryngologic symptoms. Although treatment of these symptoms has been elusive, repetitive transcranial magnetic stimulation (rTMS) has been suggested as an effective corrective therapy. Objective The objective of the study was to assess the efficacy of rTMS treatment in patients with phantosmia and phantageusia. Methods Seventeen patients with symptoms of persistent phantosmia and phantageusia with accompanying loss of smell and taste acuity were studied. Before and after treatment, patients were monitored by subjective responses and with psychophysical tests of smell function (olfactometry) and taste function (gustometry). Each patient was treated with rTMS that consisted of 2 sham procedures followed by a real rTMS procedure. Results After sham rTMS, no change in measurements of distortions or acuity occurred in any patient; after initial real rTMS, 2 patients received no benefit; but in the other 15, distortions decreased and acuity increased. Two of these 15 exhibited total inhibition of distortions and return of normal sensory acuity that persisted for over 5 years of follow-up. In the other 13, inhibition of distortions and improvement in sensory acuity gradually decreased; but repeated rTMS again inhibited their distortions and improved their acuity. Eighty-eight percent of patients responded to this therapeutic method, although repeated rTMS was necessary to induce these positive changes. Interpretation These results suggest that rTMS is a potential future therapeutic option to treat patients with the relatively common problems of persistent phantosmia and phantageusia with accompanying loss of taste and smell acuity. Additional systematic studies are necessary to confirm these results.</description><subject>Adult</subject><subject>Aged</subject><subject>Biological and medical sciences</subject><subject>Brain</subject><subject>Cranial nerves. Spinal roots. Peripheral nerves. Autonomic nervous system. Gustation. Olfaction</subject><subject>Dopamine</subject><subject>Female</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Nervous system (semeiology, syndromes)</subject><subject>Neurology</subject><subject>Neurotransmitters</subject><subject>Odors</subject><subject>Olfaction Disorders - physiopathology</subject><subject>Olfaction Disorders - therapy</subject><subject>Otolaryngology</subject><subject>Otorhinolaryngology. Stomatology</subject><subject>Placebo effect</subject><subject>Prospective Studies</subject><subject>Smell</subject><subject>Surgery</subject><subject>Taste</subject><subject>Taste Disorders - physiopathology</subject><subject>Taste Disorders - therapy</subject><subject>Transcranial Magnetic Stimulation</subject><subject>Treatment Outcome</subject><issn>0196-0709</issn><issn>1532-818X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkl2L1DAUhoMo7rj6D0QCIl7NePLRNr0RZPFjYcELFbyRkE1PJbVNxyQdmH_vKTO6sDcSSODkOW_e8xLGngvYCRD1m2HnpmEu804CtFTaAYgHbCMqJbdGmO8P2QZEW2-hgfaCPcl5AAClVfWYXVCLlHWtNuzH9bRP8wEnjIWHyPOE48hd7HhxuSDvjrlfoi9hjtz1BRNPuMcSSjggL8nF7GkLbuST-xnpwvNcwrSMbm15yh71bsz47Hxesm8f3n-9-rS9-fzx-urdzdbrRpdt1ZsGHHrZgTGmQt1J7XrjOjQGtWqF82S2qeoeNLSqEg6N1qL35raplQB1yV6fdGmW3wvmYqeQPU3iIs5LtkbUylRGaCJf3iOHeUmRzFnSEVpCVUmi9Inyac45YW_3KUwuHQmya_p2sKf07Zr-WqX0qe3FWXy5nbD71_Q3bgJenQGXvRt7is6HfMepptWyXoXenjik0A4Bk80-YPTYhYS-2G4O_3NyX8CPIQZ68xceMd_NbLO0YL-sP2X9KLTIKhj1B51EudY</recordid><startdate>2011</startdate><enddate>2011</enddate><creator>Henkin, Robert I., MD, PhD</creator><creator>Potolicchio, Samuel J., MD</creator><creator>Levy, Lucien M., MD, PhD</creator><general>Elsevier Inc</general><general>Elsevier</general><general>Elsevier Limited</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>7QR</scope><scope>7TK</scope><scope>8FD</scope><scope>FR3</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>2011</creationdate><title>Improvement in smell and taste dysfunction after repetitive transcranial magnetic stimulation</title><author>Henkin, Robert I., MD, PhD ; Potolicchio, Samuel J., MD ; Levy, Lucien M., MD, PhD</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c474t-5f870aec2d08885e4d24af8ade88e4391ac663756f0409351ae8441fc8b763103</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Biological and medical sciences</topic><topic>Brain</topic><topic>Cranial nerves. Spinal roots. Peripheral nerves. Autonomic nervous system. Gustation. Olfaction</topic><topic>Dopamine</topic><topic>Female</topic><topic>Humans</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Nervous system (semeiology, syndromes)</topic><topic>Neurology</topic><topic>Neurotransmitters</topic><topic>Odors</topic><topic>Olfaction Disorders - physiopathology</topic><topic>Olfaction Disorders - therapy</topic><topic>Otolaryngology</topic><topic>Otorhinolaryngology. Stomatology</topic><topic>Placebo effect</topic><topic>Prospective Studies</topic><topic>Smell</topic><topic>Surgery</topic><topic>Taste</topic><topic>Taste Disorders - physiopathology</topic><topic>Taste Disorders - therapy</topic><topic>Transcranial Magnetic Stimulation</topic><topic>Treatment Outcome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Henkin, Robert I., MD, PhD</creatorcontrib><creatorcontrib>Potolicchio, Samuel J., MD</creatorcontrib><creatorcontrib>Levy, Lucien M., MD, PhD</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>American journal of otolaryngology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Henkin, Robert I., MD, PhD</au><au>Potolicchio, Samuel J., MD</au><au>Levy, Lucien M., MD, PhD</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Improvement in smell and taste dysfunction after repetitive transcranial magnetic stimulation</atitle><jtitle>American journal of otolaryngology</jtitle><addtitle>Am J Otolaryngol</addtitle><date>2011</date><risdate>2011</risdate><volume>32</volume><issue>1</issue><spage>38</spage><epage>46</epage><pages>38-46</pages><issn>0196-0709</issn><eissn>1532-818X</eissn><coden>AJOTDP</coden><abstract>Abstract Background Olfactory and gustatory distortions in the absence of odors or tastants (phantosmia and phantageusia, respectively) with accompanying loss of smell and taste acuity are relatively common symptoms that can occur without other otolaryngologic symptoms. Although treatment of these symptoms has been elusive, repetitive transcranial magnetic stimulation (rTMS) has been suggested as an effective corrective therapy. Objective The objective of the study was to assess the efficacy of rTMS treatment in patients with phantosmia and phantageusia. Methods Seventeen patients with symptoms of persistent phantosmia and phantageusia with accompanying loss of smell and taste acuity were studied. Before and after treatment, patients were monitored by subjective responses and with psychophysical tests of smell function (olfactometry) and taste function (gustometry). Each patient was treated with rTMS that consisted of 2 sham procedures followed by a real rTMS procedure. Results After sham rTMS, no change in measurements of distortions or acuity occurred in any patient; after initial real rTMS, 2 patients received no benefit; but in the other 15, distortions decreased and acuity increased. Two of these 15 exhibited total inhibition of distortions and return of normal sensory acuity that persisted for over 5 years of follow-up. In the other 13, inhibition of distortions and improvement in sensory acuity gradually decreased; but repeated rTMS again inhibited their distortions and improved their acuity. Eighty-eight percent of patients responded to this therapeutic method, although repeated rTMS was necessary to induce these positive changes. Interpretation These results suggest that rTMS is a potential future therapeutic option to treat patients with the relatively common problems of persistent phantosmia and phantageusia with accompanying loss of taste and smell acuity. Additional systematic studies are necessary to confirm these results.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>20022663</pmid><doi>10.1016/j.amjoto.2009.10.001</doi><tpages>9</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0196-0709 |
| ispartof | American journal of otolaryngology, 2011, Vol.32 (1), p.38-46 |
| issn | 0196-0709 1532-818X |
| language | eng |
| recordid | cdi_proquest_miscellaneous_816385814 |
| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Adult Aged Biological and medical sciences Brain Cranial nerves. Spinal roots. Peripheral nerves. Autonomic nervous system. Gustation. Olfaction Dopamine Female Humans Male Medical sciences Middle Aged Nervous system (semeiology, syndromes) Neurology Neurotransmitters Odors Olfaction Disorders - physiopathology Olfaction Disorders - therapy Otolaryngology Otorhinolaryngology. Stomatology Placebo effect Prospective Studies Smell Surgery Taste Taste Disorders - physiopathology Taste Disorders - therapy Transcranial Magnetic Stimulation Treatment Outcome |
| title | Improvement in smell and taste dysfunction after repetitive transcranial magnetic stimulation |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-23T20%3A01%3A18IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Improvement%20in%20smell%20and%20taste%20dysfunction%20after%20repetitive%20transcranial%20magnetic%20stimulation&rft.jtitle=American%20journal%20of%20otolaryngology&rft.au=Henkin,%20Robert%20I.,%20MD,%20PhD&rft.date=2011&rft.volume=32&rft.issue=1&rft.spage=38&rft.epage=46&rft.pages=38-46&rft.issn=0196-0709&rft.eissn=1532-818X&rft.coden=AJOTDP&rft_id=info:doi/10.1016/j.amjoto.2009.10.001&rft_dat=%3Cproquest_cross%3E2730050181%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1031420552&rft_id=info:pmid/20022663&rft_els_id=S0196070909002208&rfr_iscdi=true |