Tenascin-C deficiency attenuates TGF-ß-mediated fibrosis following murine lung injury

Tenascin-C (TNC) is an extracellular matrix glycoprotein of unknown function that is highly expressed in adult lung parenchyma following acute lung injury (ALI). Here we report that mice lacking TNC are protected from interstitial fibrosis in the bleomycin model of ALI. Three weeks after exposure to...

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Veröffentlicht in:	American journal of physiology. Lung cellular and molecular physiology 2010-12, Vol.299 (6), p.L785-L793
Hauptverfasser:	Carey, William A, Taylor, Glen D, Dean, Willow B, Bristow, James D
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell Line Collagen - metabolism Fibroblasts - cytology Fibroblasts - metabolism Fibrosis - metabolism Fibrosis - pathology Humans Lung - metabolism Lung - pathology Lung Injury - metabolism Lung Injury - pathology Mice Mice, Knockout Signal Transduction - physiology Smad3 Protein - genetics Smad3 Protein - metabolism Tenascin - deficiency Transforming Growth Factor beta - metabolism
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