Functional proteomic analysis of promyelocytic leukaemia nuclear bodies in irradiation-induced MCF-7 cells

It is well established that promyelocytic leukaemia nuclear bodies (PML NBs) play important roles in DNA damage responses (DDR). After irradiation, PML NBs dynamically recruit or release important proteins involved in cell-cycle regulation, DNA repair and apoptosis. As PML protein is the key molecul...

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Veröffentlicht in:	Journal of biochemistry (Tokyo) 2010-12, Vol.148 (6), p.659-667
Hauptverfasser:	Liu, Jinfeng, Song, Yi, Tian, Baolei, Qian, Junjie, Dong, Yan, Liu, Jilai, Liu, Bin, Sun, Zhixian
Format:	Artikel
Sprache:	eng
Schlagworte:	Apoptosis - radiation effects Breast Neoplasms - metabolism Cell Cycle Proteins - physiology Cell Line, Tumor Cell Nucleus Structures - metabolism Cell Nucleus Structures - radiation effects Cell Nucleus Structures - ultrastructure DNA Damage - radiation effects DNA damage response DNA Repair - radiation effects DNA, Neoplasm - metabolism Female Humans Leukemia, Promyelocytic, Acute - metabolism Microscopy, Fluorescence Neoplasm Proteins - metabolism Neoplasm Proteins - ultrastructure Nuclear Proteins - metabolism Nuclear Proteins - ultrastructure PML NBs Promyelocytic Leukemia Protein proteomic analysis Proteomics Transcription Factors - metabolism Transcription Factors - ultrastructure Tumor Suppressor Proteins - metabolism Tumor Suppressor Proteins - physiology Tumor Suppressor Proteins - radiation effects Tumor Suppressor Proteins - ultrastructure
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