Liquid Nitrogen: Temperature Control in the Treatment of Actinic Keratosis
BACKGROUND Actinic keratoses (AKs) are in situ epidermal tumors that may progress to invasive squamous cell carcinomas. Liquid nitrogen is used during cryotherapy to freeze the epidermis and upper dermis and is the standard treatment for individual AKs. OBJECTIVE To evaluate the efficacy of a cryosu...
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| Veröffentlicht in: | Dermatologic surgery 2010-12, Vol.36 (12), p.1956-1961 |
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| container_end_page | 1961 |
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| container_issue | 12 |
| container_start_page | 1956 |
| container_title | Dermatologic surgery |
| container_volume | 36 |
| creator | GOLDBERG, LEONARD H. KAPLAN, BARUCH VERGILIS‐KALNER, IRENE LANDAU, JENNIFER |
| description | BACKGROUND
Actinic keratoses (AKs) are in situ epidermal tumors that may progress to invasive squamous cell carcinomas. Liquid nitrogen is used during cryotherapy to freeze the epidermis and upper dermis and is the standard treatment for individual AKs.
OBJECTIVE
To evaluate the efficacy of a cryosurgery device incorporating an infrared sensor to measure the temperature at the skin surface while spraying liquid nitrogen on the surface of the skin during the treatment of AKs.
METHODS & MATERIALS
Thirty‐six patients with 180 thin AKs were treated with liquid nitrogen spray to a temperature of −5°C using the sensor to control the temperature at the skin surface. Patients were evaluated for cure rate, side effects, and healing time.
RESULTS
At the 1‐week follow‐up, 66.7% of the lesions were cleared. By the 6‐week follow‐up, there was a 100% cure rate. Side effects were limited to redness, blistering, crusting, oozing, and ulceration at the 1‐week follow‐up and were resolved by the 6‐week follow‐up. No recurrence of AK, scarring, or hypopigmentation was noted.
CONCLUSION
Cryotherapy with an integrated sensor for temperature control is an effective, safe, and precise treatment, allowing for a 100% short‐term cure rate of AKs.
The Cryotracker used in this study was given to the authors by the Brymill Company. |
| doi_str_mv | 10.1111/j.1524-4725.2010.01804.x |
| format | Article |
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Actinic keratoses (AKs) are in situ epidermal tumors that may progress to invasive squamous cell carcinomas. Liquid nitrogen is used during cryotherapy to freeze the epidermis and upper dermis and is the standard treatment for individual AKs.
OBJECTIVE
To evaluate the efficacy of a cryosurgery device incorporating an infrared sensor to measure the temperature at the skin surface while spraying liquid nitrogen on the surface of the skin during the treatment of AKs.
METHODS & MATERIALS
Thirty‐six patients with 180 thin AKs were treated with liquid nitrogen spray to a temperature of −5°C using the sensor to control the temperature at the skin surface. Patients were evaluated for cure rate, side effects, and healing time.
RESULTS
At the 1‐week follow‐up, 66.7% of the lesions were cleared. By the 6‐week follow‐up, there was a 100% cure rate. Side effects were limited to redness, blistering, crusting, oozing, and ulceration at the 1‐week follow‐up and were resolved by the 6‐week follow‐up. No recurrence of AK, scarring, or hypopigmentation was noted.
CONCLUSION
Cryotherapy with an integrated sensor for temperature control is an effective, safe, and precise treatment, allowing for a 100% short‐term cure rate of AKs.
The Cryotracker used in this study was given to the authors by the Brymill Company.</description><identifier>ISSN: 1076-0512</identifier><identifier>EISSN: 1524-4725</identifier><identifier>DOI: 10.1111/j.1524-4725.2010.01804.x</identifier><identifier>PMID: 21070460</identifier><language>eng</language><publisher>Malden, USA: Blackwell Publishing Inc</publisher><subject>Biological and medical sciences ; Cryosurgery - instrumentation ; Cryosurgery - methods ; Dermatology ; Female ; Humans ; Keratosis, Actinic - surgery ; Male ; Medical sciences ; Nitrogen - therapeutic use ; Patient Satisfaction ; Postoperative Complications ; Skin plastic surgery ; Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases ; Treatment Outcome</subject><ispartof>Dermatologic surgery, 2010-12, Vol.36 (12), p.1956-1961</ispartof><rights>2010 by the American Society for Dermatologic Surgery, Inc.</rights><rights>2015 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4438-ae9cb05230b3354842dde37f961af53bd50ac7979691056da7f9ce0bee30e7093</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1524-4725.2010.01804.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1524-4725.2010.01804.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=23707087$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21070460$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>GOLDBERG, LEONARD H.</creatorcontrib><creatorcontrib>KAPLAN, BARUCH</creatorcontrib><creatorcontrib>VERGILIS‐KALNER, IRENE</creatorcontrib><creatorcontrib>LANDAU, JENNIFER</creatorcontrib><title>Liquid Nitrogen: Temperature Control in the Treatment of Actinic Keratosis</title><title>Dermatologic surgery</title><addtitle>Dermatol Surg</addtitle><description>BACKGROUND
Actinic keratoses (AKs) are in situ epidermal tumors that may progress to invasive squamous cell carcinomas. Liquid nitrogen is used during cryotherapy to freeze the epidermis and upper dermis and is the standard treatment for individual AKs.
OBJECTIVE
To evaluate the efficacy of a cryosurgery device incorporating an infrared sensor to measure the temperature at the skin surface while spraying liquid nitrogen on the surface of the skin during the treatment of AKs.
METHODS & MATERIALS
Thirty‐six patients with 180 thin AKs were treated with liquid nitrogen spray to a temperature of −5°C using the sensor to control the temperature at the skin surface. Patients were evaluated for cure rate, side effects, and healing time.
RESULTS
At the 1‐week follow‐up, 66.7% of the lesions were cleared. By the 6‐week follow‐up, there was a 100% cure rate. Side effects were limited to redness, blistering, crusting, oozing, and ulceration at the 1‐week follow‐up and were resolved by the 6‐week follow‐up. No recurrence of AK, scarring, or hypopigmentation was noted.
CONCLUSION
Cryotherapy with an integrated sensor for temperature control is an effective, safe, and precise treatment, allowing for a 100% short‐term cure rate of AKs.
The Cryotracker used in this study was given to the authors by the Brymill Company.</description><subject>Biological and medical sciences</subject><subject>Cryosurgery - instrumentation</subject><subject>Cryosurgery - methods</subject><subject>Dermatology</subject><subject>Female</subject><subject>Humans</subject><subject>Keratosis, Actinic - surgery</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Nitrogen - therapeutic use</subject><subject>Patient Satisfaction</subject><subject>Postoperative Complications</subject><subject>Skin plastic surgery</subject><subject>Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</subject><subject>Treatment Outcome</subject><issn>1076-0512</issn><issn>1524-4725</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkEtv1DAUhS0EoqXwF5A3iFWG61ceSCyqKe8RLJiuLce5YTw4ydR21Pbf4zBD2WLJ8vU93_G1DiGUwYrl9Wa_YorLQlZcrTjkLrAa5OruETl_EB7nGqqyAMX4GXkW4x6A8UbAU3LGswKyhHPyZeNuZtfRby6F6SeOb-kWhwMGk-aAdD2Nue2pG2naId0GNGnAMdGpp5c2udFZ-nWBp-jic_KkNz7ii9N5Qa4_vN-uPxWb7x8_ry83hZVS1IXBxraguIBWCCVrybsORdU3JTO9Em2nwNiqqZqyYaDKzmTJIrSIArCCRlyQ18d3D2G6mTEmPbho0Xsz4jRHXTPVlErIhayPpA1TjAF7fQhuMOFeM9BLkHqvl7z0kpdegtR_gtR32fryNGRuB-wejH-Ty8CrE2CiNb4PZrQu_uNElcG6ypw8creTTxjiLz_fYtA7ND7tNABIXvG6WIYznq9F3lBn27uTzXm8_-9_66sf10slfgNh0Z0E</recordid><startdate>201012</startdate><enddate>201012</enddate><creator>GOLDBERG, LEONARD H.</creator><creator>KAPLAN, BARUCH</creator><creator>VERGILIS‐KALNER, IRENE</creator><creator>LANDAU, JENNIFER</creator><general>Blackwell Publishing Inc</general><general>by the American Society for Dermatologic Surgery, Inc</general><general>Wiley</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201012</creationdate><title>Liquid Nitrogen: Temperature Control in the Treatment of Actinic Keratosis</title><author>GOLDBERG, LEONARD H. ; KAPLAN, BARUCH ; VERGILIS‐KALNER, IRENE ; LANDAU, JENNIFER</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4438-ae9cb05230b3354842dde37f961af53bd50ac7979691056da7f9ce0bee30e7093</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Biological and medical sciences</topic><topic>Cryosurgery - instrumentation</topic><topic>Cryosurgery - methods</topic><topic>Dermatology</topic><topic>Female</topic><topic>Humans</topic><topic>Keratosis, Actinic - surgery</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Nitrogen - therapeutic use</topic><topic>Patient Satisfaction</topic><topic>Postoperative Complications</topic><topic>Skin plastic surgery</topic><topic>Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</topic><topic>Treatment Outcome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>GOLDBERG, LEONARD H.</creatorcontrib><creatorcontrib>KAPLAN, BARUCH</creatorcontrib><creatorcontrib>VERGILIS‐KALNER, IRENE</creatorcontrib><creatorcontrib>LANDAU, JENNIFER</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Dermatologic surgery</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>GOLDBERG, LEONARD H.</au><au>KAPLAN, BARUCH</au><au>VERGILIS‐KALNER, IRENE</au><au>LANDAU, JENNIFER</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Liquid Nitrogen: Temperature Control in the Treatment of Actinic Keratosis</atitle><jtitle>Dermatologic surgery</jtitle><addtitle>Dermatol Surg</addtitle><date>2010-12</date><risdate>2010</risdate><volume>36</volume><issue>12</issue><spage>1956</spage><epage>1961</epage><pages>1956-1961</pages><issn>1076-0512</issn><eissn>1524-4725</eissn><abstract>BACKGROUND
Actinic keratoses (AKs) are in situ epidermal tumors that may progress to invasive squamous cell carcinomas. Liquid nitrogen is used during cryotherapy to freeze the epidermis and upper dermis and is the standard treatment for individual AKs.
OBJECTIVE
To evaluate the efficacy of a cryosurgery device incorporating an infrared sensor to measure the temperature at the skin surface while spraying liquid nitrogen on the surface of the skin during the treatment of AKs.
METHODS & MATERIALS
Thirty‐six patients with 180 thin AKs were treated with liquid nitrogen spray to a temperature of −5°C using the sensor to control the temperature at the skin surface. Patients were evaluated for cure rate, side effects, and healing time.
RESULTS
At the 1‐week follow‐up, 66.7% of the lesions were cleared. By the 6‐week follow‐up, there was a 100% cure rate. Side effects were limited to redness, blistering, crusting, oozing, and ulceration at the 1‐week follow‐up and were resolved by the 6‐week follow‐up. No recurrence of AK, scarring, or hypopigmentation was noted.
CONCLUSION
Cryotherapy with an integrated sensor for temperature control is an effective, safe, and precise treatment, allowing for a 100% short‐term cure rate of AKs.
The Cryotracker used in this study was given to the authors by the Brymill Company.</abstract><cop>Malden, USA</cop><pub>Blackwell Publishing Inc</pub><pmid>21070460</pmid><doi>10.1111/j.1524-4725.2010.01804.x</doi><tpages>6</tpages></addata></record> |
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| ispartof | Dermatologic surgery, 2010-12, Vol.36 (12), p.1956-1961 |
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| language | eng |
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| source | MEDLINE; Wiley Journals; Journals@Ovid Ovid Autoload |
| subjects | Biological and medical sciences Cryosurgery - instrumentation Cryosurgery - methods Dermatology Female Humans Keratosis, Actinic - surgery Male Medical sciences Nitrogen - therapeutic use Patient Satisfaction Postoperative Complications Skin plastic surgery Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases Treatment Outcome |
| title | Liquid Nitrogen: Temperature Control in the Treatment of Actinic Keratosis |
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