AMP-activated protein kinase regulates glucagon secretion from mouse pancreatic alpha cells

Aim/hypothesis AMP-activated protein kinase (AMPK), encoded by Prkaa genes, is emerging as a key regulator of overall energy homeostasis and the control of insulin secretion and action. We sought here to investigate the role of AMPK in controlling glucagon secretion from pancreatic islet alpha cells...

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Veröffentlicht in:	Diabetologia 2011-01, Vol.54 (1), p.125-134
Hauptverfasser:	Leclerc, I, Sun, G, Morris, C, Fernandez-Millan, E, Nyirenda, M, Rutter, G. A
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetyltransferases - metabolism Adenosine Triphosphate - metabolism AMP-activated protein kinase AMP-Activated Protein Kinases - genetics AMP-Activated Protein Kinases - metabolism Animals Biological and medical sciences Blotting, Western Calcium - metabolism Cell Line Diabetes. Impaired glucose tolerance Endocrine pancreas. Apud cells (diseases) Endocrinopathies Enzyme Activation - drug effects Enzymes Etiopathogenesis. Screening. Investigations. Target tissue resistance Female Glucagon Glucagon - metabolism Glucagon secretion Glucagon-Secreting Cells - drug effects Glucagon-Secreting Cells - enzymology Glucagon-Secreting Cells - metabolism Glucose Glucose - metabolism Human Physiology Hypoglycemia Hypoglycemic Agents - pharmacology Immunohistochemistry Insulin Internal Medicine islets of Langerhans Kinases Medical sciences Medicine Medicine & Public Health Metabolic Diseases Metabolism Metformin - pharmacology Mice Pancreatic islets of Langerhans Phenformin - pharmacology Phosphorylation - drug effects Proteins Pyrones - pharmacology Thiophenes - pharmacology
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