Cancer stem cells: problems for therapy

Many, if not all, tumours contain a sub-population of self-renewing and expanding stem cells known as cancer stem cells (CSCs). The symmetric division of CSCs is one mechanism enabling expansion in their numbers as tumours grow, while epithelial-mesenchymal transition (EMT) is an increasingly recogn...

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Veröffentlicht in:	The Journal of pathology 2011-01, Vol.223 (2), p.148-162
Hauptverfasser:	Alison, Malcolm R, Lim, Susan ML, Nicholson, Linda J
Format:	Artikel
Sprache:	eng
Schlagworte:	ALDEFUOR Aldehyde dehydrogenase ALHD Animals Cancer Cell culture Cell Transformation, Neoplastic - pathology Disease Progression drug resistance Enzymes epigenetics Epithelial-Mesenchymal Transition Evolution Hedgehog signalling Humans immunodeficient mice Invasiveness Metastases Mice miRNA Neoplasm Invasiveness Neoplasm Metastasis Neoplasms - pathology Neoplasms - therapy Neoplasms, Experimental - pathology Neoplastic Stem Cells - pathology Notch protein Notch signalling Prognosis Reviews Stem cells Surface markers Tumors tumour-propagating cells Wnt protein Wnt signalling
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