NMR Reveals Two-Step Association of Congo Red to Amyloid β in Low-Molecular-Weight Aggregates

Aggregation of the Amyloid β peptide into amyloid fibrils is closely related to development of Alzheimer’s disease. Many small aromatic compounds have been found to act as inhibitors of fibril formation, and have inspired the search for new drug candidates. However, the detailed mechanisms of inhibi...

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Veröffentlicht in:	The journal of physical chemistry. B 2010-12, Vol.114 (48), p.16003-16010
Hauptverfasser:	Pedersen, Marie Ø, Mikkelsen, Katrine, Behrens, Manja A, Pedersen, Jan S, Enghild, Jan J, Skrydstrup, Troels, Malmendal, Anders, Nielsen, Niels Chr
Format:	Artikel
Sprache:	eng
Schlagworte:	Amyloid beta-Peptides - antagonists & inhibitors Amyloid beta-Peptides - chemistry B: Biophysical Chemistry Congo Red - chemistry Congo Red - pharmacology Diffusion Light Magnetic Resonance Spectroscopy Molecular Structure Molecular Weight Peptide Fragments - antagonists & inhibitors Peptide Fragments - chemistry Scattering, Radiation
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