An improved constant current source for micro-iontophoretic drug application studies
A simple circuit is described for injecting current into micropipettes for electrophoresing and retaining chemical substances. Due to the high voltage output amplifier employed, it will deliver a high (500 nA) current through a very high resistance (200 MΩ) drug micropipette. Provision is made for i...
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Veröffentlicht in: | Electroencephalography and clinical neurophysiology 1972-10, Vol.33 (4), p.430-432 |
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container_title | Electroencephalography and clinical neurophysiology |
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creator | Geller, H.M Woodward, D.J |
description | A simple circuit is described for injecting current into micropipettes for electrophoresing and retaining chemical substances. Due to the high voltage output amplifier employed, it will deliver a high (500 nA) current through a very high resistance (200 MΩ) drug micropipette. Provision is made for injecting a balancing current equal in magnitude and opposite in polarity to the sum of the injection currents, for recording a signal proportional to output current and for controlling current injection with external devices.
Les auteurs décrivent un circuit simple d'injection de courant dans des micro-pipettes pour réaliser l'électrophorèse et la rétention de substances chimiques. En raison des amplificateurs de sortie de haut voltage utilisés, ce circuit délivre un courant élvé (500 nA) au travers d'une micro-pipette à médicaments de très haute résistance (200 MΩ). Il se fait ainsi une provision permettant d'injecter un courant équilibré, de puissance égale et de polarité opposée à la somme des courants injectés, permettant d'enregisterer un signal proportionnel au courant de sortie et de contrôler l'injection de courant par des systèmes externes. |
doi_str_mv | 10.1016/0013-4694(72)90125-3 |
format | Article |
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Les auteurs décrivent un circuit simple d'injection de courant dans des micro-pipettes pour réaliser l'électrophorèse et la rétention de substances chimiques. En raison des amplificateurs de sortie de haut voltage utilisés, ce circuit délivre un courant élvé (500 nA) au travers d'une micro-pipette à médicaments de très haute résistance (200 MΩ). Il se fait ainsi une provision permettant d'injecter un courant équilibré, de puissance égale et de polarité opposée à la somme des courants injectés, permettant d'enregisterer un signal proportionnel au courant de sortie et de contrôler l'injection de courant par des systèmes externes.</description><identifier>ISSN: 0013-4694</identifier><identifier>EISSN: 1872-6380</identifier><identifier>DOI: 10.1016/0013-4694(72)90125-3</identifier><identifier>PMID: 4115703</identifier><language>eng</language><publisher>Ireland: Elsevier Ireland Ltd</publisher><subject>Amplifiers, Electronic ; Animals ; Electronics - instrumentation ; Iontophoresis ; Neurophysiology - instrumentation ; Psychopharmacology - instrumentation</subject><ispartof>Electroencephalography and clinical neurophysiology, 1972-10, Vol.33 (4), p.430-432</ispartof><rights>1972</rights><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c357t-eead61e37d504128ebc52ae20b8683f1c873c93b1b038edd2bb92f9c538dc8073</citedby><cites>FETCH-LOGICAL-c357t-eead61e37d504128ebc52ae20b8683f1c873c93b1b038edd2bb92f9c538dc8073</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27903,27904</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/4115703$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Geller, H.M</creatorcontrib><creatorcontrib>Woodward, D.J</creatorcontrib><title>An improved constant current source for micro-iontophoretic drug application studies</title><title>Electroencephalography and clinical neurophysiology</title><addtitle>Electroencephalogr Clin Neurophysiol</addtitle><description>A simple circuit is described for injecting current into micropipettes for electrophoresing and retaining chemical substances. Due to the high voltage output amplifier employed, it will deliver a high (500 nA) current through a very high resistance (200 MΩ) drug micropipette. Provision is made for injecting a balancing current equal in magnitude and opposite in polarity to the sum of the injection currents, for recording a signal proportional to output current and for controlling current injection with external devices.
Les auteurs décrivent un circuit simple d'injection de courant dans des micro-pipettes pour réaliser l'électrophorèse et la rétention de substances chimiques. En raison des amplificateurs de sortie de haut voltage utilisés, ce circuit délivre un courant élvé (500 nA) au travers d'une micro-pipette à médicaments de très haute résistance (200 MΩ). Il se fait ainsi une provision permettant d'injecter un courant équilibré, de puissance égale et de polarité opposée à la somme des courants injectés, permettant d'enregisterer un signal proportionnel au courant de sortie et de contrôler l'injection de courant par des systèmes externes.</description><subject>Amplifiers, Electronic</subject><subject>Animals</subject><subject>Electronics - instrumentation</subject><subject>Iontophoresis</subject><subject>Neurophysiology - instrumentation</subject><subject>Psychopharmacology - instrumentation</subject><issn>0013-4694</issn><issn>1872-6380</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1972</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kEtPwzAQhC0EKqXwD0DKCcEh4EcSOxekquIlVeJSzpZjb8CoiYPtVOLf49KqR057mJndnQ-hS4LvCCbVPcaE5UVVFzec3taY0DJnR2hKBKd5xQQ-RtOD5RSdhfCFMaaE8gmaFISUHLMpWs37zHaDdxswmXZ9iKqPmR69hzSDG72GrHU-66z2Lreuj274dB6i1Znx40emhmFttYpJykIcjYVwjk5atQ5wsZ8z9P70uFq85Mu359fFfJlrVvKYAyhTEWDclLggVECjS6qA4kZUgrVEC850zRrSYCbAGNo0NW1rXTJhtMCczdD1bm_6_3uEEGVng4b1WvXgxiBFKinKiiRjsTOmDiF4aOXgbaf8jyRYbmHKLSm5JSU5lX8wJUuxq_3-senAHEJ7ekl_2OmQSm4seBm0hV6DsR50lMbZ_w_8Ai0lhNo</recordid><startdate>197210</startdate><enddate>197210</enddate><creator>Geller, H.M</creator><creator>Woodward, D.J</creator><general>Elsevier Ireland Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>197210</creationdate><title>An improved constant current source for micro-iontophoretic drug application studies</title><author>Geller, H.M ; Woodward, D.J</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c357t-eead61e37d504128ebc52ae20b8683f1c873c93b1b038edd2bb92f9c538dc8073</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1972</creationdate><topic>Amplifiers, Electronic</topic><topic>Animals</topic><topic>Electronics - instrumentation</topic><topic>Iontophoresis</topic><topic>Neurophysiology - instrumentation</topic><topic>Psychopharmacology - instrumentation</topic><toplevel>online_resources</toplevel><creatorcontrib>Geller, H.M</creatorcontrib><creatorcontrib>Woodward, D.J</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Electroencephalography and clinical neurophysiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Geller, H.M</au><au>Woodward, D.J</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>An improved constant current source for micro-iontophoretic drug application studies</atitle><jtitle>Electroencephalography and clinical neurophysiology</jtitle><addtitle>Electroencephalogr Clin Neurophysiol</addtitle><date>1972-10</date><risdate>1972</risdate><volume>33</volume><issue>4</issue><spage>430</spage><epage>432</epage><pages>430-432</pages><issn>0013-4694</issn><eissn>1872-6380</eissn><abstract>A simple circuit is described for injecting current into micropipettes for electrophoresing and retaining chemical substances. Due to the high voltage output amplifier employed, it will deliver a high (500 nA) current through a very high resistance (200 MΩ) drug micropipette. Provision is made for injecting a balancing current equal in magnitude and opposite in polarity to the sum of the injection currents, for recording a signal proportional to output current and for controlling current injection with external devices.
Les auteurs décrivent un circuit simple d'injection de courant dans des micro-pipettes pour réaliser l'électrophorèse et la rétention de substances chimiques. En raison des amplificateurs de sortie de haut voltage utilisés, ce circuit délivre un courant élvé (500 nA) au travers d'une micro-pipette à médicaments de très haute résistance (200 MΩ). Il se fait ainsi une provision permettant d'injecter un courant équilibré, de puissance égale et de polarité opposée à la somme des courants injectés, permettant d'enregisterer un signal proportionnel au courant de sortie et de contrôler l'injection de courant par des systèmes externes.</abstract><cop>Ireland</cop><pub>Elsevier Ireland Ltd</pub><pmid>4115703</pmid><doi>10.1016/0013-4694(72)90125-3</doi><tpages>3</tpages></addata></record> |
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source | MEDLINE; Alma/SFX Local Collection |
subjects | Amplifiers, Electronic Animals Electronics - instrumentation Iontophoresis Neurophysiology - instrumentation Psychopharmacology - instrumentation |
title | An improved constant current source for micro-iontophoretic drug application studies |
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