An improved constant current source for micro-iontophoretic drug application studies

A simple circuit is described for injecting current into micropipettes for electrophoresing and retaining chemical substances. Due to the high voltage output amplifier employed, it will deliver a high (500 nA) current through a very high resistance (200 MΩ) drug micropipette. Provision is made for i...

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Veröffentlicht in:Electroencephalography and clinical neurophysiology 1972-10, Vol.33 (4), p.430-432
Hauptverfasser: Geller, H.M, Woodward, D.J
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container_issue 4
container_start_page 430
container_title Electroencephalography and clinical neurophysiology
container_volume 33
creator Geller, H.M
Woodward, D.J
description A simple circuit is described for injecting current into micropipettes for electrophoresing and retaining chemical substances. Due to the high voltage output amplifier employed, it will deliver a high (500 nA) current through a very high resistance (200 MΩ) drug micropipette. Provision is made for injecting a balancing current equal in magnitude and opposite in polarity to the sum of the injection currents, for recording a signal proportional to output current and for controlling current injection with external devices. Les auteurs décrivent un circuit simple d'injection de courant dans des micro-pipettes pour réaliser l'électrophorèse et la rétention de substances chimiques. En raison des amplificateurs de sortie de haut voltage utilisés, ce circuit délivre un courant élvé (500 nA) au travers d'une micro-pipette à médicaments de très haute résistance (200 MΩ). Il se fait ainsi une provision permettant d'injecter un courant équilibré, de puissance égale et de polarité opposée à la somme des courants injectés, permettant d'enregisterer un signal proportionnel au courant de sortie et de contrôler l'injection de courant par des systèmes externes.
doi_str_mv 10.1016/0013-4694(72)90125-3
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subjects Amplifiers, Electronic
Animals
Electronics - instrumentation
Iontophoresis
Neurophysiology - instrumentation
Psychopharmacology - instrumentation
title An improved constant current source for micro-iontophoretic drug application studies
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