Plasma proteins, oxygen transport and atherosclerosis
In summary, we have presented evidence to support the hypoxic theory for the formation of atherosclerosis. More importantly, though, we have presented the following etiology for such hypoxia: 1. (1) Oxygen transport is affected by plasma protein concentrations and in most humans probably decreases w...
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| Veröffentlicht in: | Atherosclerosis 1972-05, Vol.15 (3), p.327-343 |
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| container_title | Atherosclerosis |
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| creator | Chisolm, G.M. Gainer, John L. Stoner, G.E. Gainer, James V. |
| description | In summary, we have presented evidence to support the hypoxic theory for the formation of atherosclerosis. More importantly, though, we have presented the following etiology for such hypoxia:
1.
(1) Oxygen transport is affected by plasma protein concentrations and in most humans probably decreases with age;
2.
(2) The result of hypoxia at the aortic lining is a degeneration of surface features which results in increased cellular permeability; and
3.
(3) The interior structure of the vessel is further disorganized due to the influx of lipids and other plasmatic matter. This in turn accelerates oxygen demand and augments hypoxia.
These ideas concerning the effects of proteins on oxygen transport, as well as the importance of the diffusion resistance of blood plasma, provide strong indications of a comprehensive mechanism for the occurrence of atherosclerosis and other vascular changes associated with aging. |
| doi_str_mv | 10.1016/0021-9150(72)90022-6 |
| format | Article |
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1.
(1) Oxygen transport is affected by plasma protein concentrations and in most humans probably decreases with age;
2.
(2) The result of hypoxia at the aortic lining is a degeneration of surface features which results in increased cellular permeability; and
3.
(3) The interior structure of the vessel is further disorganized due to the influx of lipids and other plasmatic matter. This in turn accelerates oxygen demand and augments hypoxia.
These ideas concerning the effects of proteins on oxygen transport, as well as the importance of the diffusion resistance of blood plasma, provide strong indications of a comprehensive mechanism for the occurrence of atherosclerosis and other vascular changes associated with aging.</description><identifier>ISSN: 0021-9150</identifier><identifier>EISSN: 1879-1484</identifier><identifier>DOI: 10.1016/0021-9150(72)90022-6</identifier><identifier>PMID: 4115210</identifier><language>eng</language><publisher>Ireland: Elsevier Ireland Ltd</publisher><subject>Age Factors ; Animals ; Aorta - cytology ; Aortic Diseases - blood ; Arteriosclerosis - blood ; Arteriosclerosis - etiology ; Atherosclerosis ; Biological Transport ; Blood Proteins - metabolism ; Cholesterol ; Diet, Atherogenic ; Dietary Fats ; Diffusion ; Epithelial Cells ; Fibrinogen - metabolism ; gamma-Globulins - metabolism ; gamma-Globulins - pharmacology ; Humans ; Hypoxia ; Hypoxia - complications ; Injections, Intramuscular ; Microscopy, Electron ; Oxygen - blood ; Permeability ; Plasma proteins ; Rabbit aorta ; Rabbits ; Scanning electron microscopy ; Serum Albumin - metabolism ; Serum Albumin - pharmacology</subject><ispartof>Atherosclerosis, 1972-05, Vol.15 (3), p.327-343</ispartof><rights>1972</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c357t-f6dbef2208ce21e0872997d647f6a589de9b223a0920a8dbb2adfc4a6e942c5e3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0021-9150(72)90022-6$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,778,782,3539,27911,27912,45982</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/4115210$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Chisolm, G.M.</creatorcontrib><creatorcontrib>Gainer, John L.</creatorcontrib><creatorcontrib>Stoner, G.E.</creatorcontrib><creatorcontrib>Gainer, James V.</creatorcontrib><title>Plasma proteins, oxygen transport and atherosclerosis</title><title>Atherosclerosis</title><addtitle>Atherosclerosis</addtitle><description>In summary, we have presented evidence to support the hypoxic theory for the formation of atherosclerosis. More importantly, though, we have presented the following etiology for such hypoxia:
1.
(1) Oxygen transport is affected by plasma protein concentrations and in most humans probably decreases with age;
2.
(2) The result of hypoxia at the aortic lining is a degeneration of surface features which results in increased cellular permeability; and
3.
(3) The interior structure of the vessel is further disorganized due to the influx of lipids and other plasmatic matter. This in turn accelerates oxygen demand and augments hypoxia.
These ideas concerning the effects of proteins on oxygen transport, as well as the importance of the diffusion resistance of blood plasma, provide strong indications of a comprehensive mechanism for the occurrence of atherosclerosis and other vascular changes associated with aging.</description><subject>Age Factors</subject><subject>Animals</subject><subject>Aorta - cytology</subject><subject>Aortic Diseases - blood</subject><subject>Arteriosclerosis - blood</subject><subject>Arteriosclerosis - etiology</subject><subject>Atherosclerosis</subject><subject>Biological Transport</subject><subject>Blood Proteins - metabolism</subject><subject>Cholesterol</subject><subject>Diet, Atherogenic</subject><subject>Dietary Fats</subject><subject>Diffusion</subject><subject>Epithelial Cells</subject><subject>Fibrinogen - metabolism</subject><subject>gamma-Globulins - metabolism</subject><subject>gamma-Globulins - pharmacology</subject><subject>Humans</subject><subject>Hypoxia</subject><subject>Hypoxia - complications</subject><subject>Injections, Intramuscular</subject><subject>Microscopy, Electron</subject><subject>Oxygen - blood</subject><subject>Permeability</subject><subject>Plasma proteins</subject><subject>Rabbit aorta</subject><subject>Rabbits</subject><subject>Scanning electron microscopy</subject><subject>Serum Albumin - metabolism</subject><subject>Serum Albumin - pharmacology</subject><issn>0021-9150</issn><issn>1879-1484</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1972</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kMlKBDEQhoMo47i8gUKfRMHWJJ3OchFkcIMBPeg5pJNqjfQyJhlx3t5uZ5ijlyqK_6_tQ-iE4CuCCb_GmJJckRKfC3qhhormfAdNiRQqJ0yyXTTdWvbRQYyfGGMmiJygCSOkpARPUfnSmNiabBH6BL6Ll1n_s3qHLkvBdHHRh5SZzmUmfUDoo23G6OMR2qtNE-F4kw_R2_3d6-wxnz8_PM1u57ktSpHymrsKakqxtEAJYCmoUsJxJmpuSqkcqIrSwmBFsZGuqqhxtWWGg2LUllAcorP13OG8ryXEpFsfLTSN6aBfRi1JyZVkxWBka6Md7osBar0IvjVhpQnWIy09otAjCi2o_qOl-dB2upm_rFpw26YNnkG_WeswPPntIehoPXQWnA9gk3a9_3_BL3NMePg</recordid><startdate>197205</startdate><enddate>197205</enddate><creator>Chisolm, G.M.</creator><creator>Gainer, John L.</creator><creator>Stoner, G.E.</creator><creator>Gainer, James V.</creator><general>Elsevier Ireland Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>197205</creationdate><title>Plasma proteins, oxygen transport and atherosclerosis</title><author>Chisolm, G.M. ; Gainer, John L. ; Stoner, G.E. ; Gainer, James V.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c357t-f6dbef2208ce21e0872997d647f6a589de9b223a0920a8dbb2adfc4a6e942c5e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1972</creationdate><topic>Age Factors</topic><topic>Animals</topic><topic>Aorta - cytology</topic><topic>Aortic Diseases - blood</topic><topic>Arteriosclerosis - blood</topic><topic>Arteriosclerosis - etiology</topic><topic>Atherosclerosis</topic><topic>Biological Transport</topic><topic>Blood Proteins - metabolism</topic><topic>Cholesterol</topic><topic>Diet, Atherogenic</topic><topic>Dietary Fats</topic><topic>Diffusion</topic><topic>Epithelial Cells</topic><topic>Fibrinogen - metabolism</topic><topic>gamma-Globulins - metabolism</topic><topic>gamma-Globulins - pharmacology</topic><topic>Humans</topic><topic>Hypoxia</topic><topic>Hypoxia - complications</topic><topic>Injections, Intramuscular</topic><topic>Microscopy, Electron</topic><topic>Oxygen - blood</topic><topic>Permeability</topic><topic>Plasma proteins</topic><topic>Rabbit aorta</topic><topic>Rabbits</topic><topic>Scanning electron microscopy</topic><topic>Serum Albumin - metabolism</topic><topic>Serum Albumin - pharmacology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Chisolm, G.M.</creatorcontrib><creatorcontrib>Gainer, John L.</creatorcontrib><creatorcontrib>Stoner, G.E.</creatorcontrib><creatorcontrib>Gainer, James V.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Atherosclerosis</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Chisolm, G.M.</au><au>Gainer, John L.</au><au>Stoner, G.E.</au><au>Gainer, James V.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Plasma proteins, oxygen transport and atherosclerosis</atitle><jtitle>Atherosclerosis</jtitle><addtitle>Atherosclerosis</addtitle><date>1972-05</date><risdate>1972</risdate><volume>15</volume><issue>3</issue><spage>327</spage><epage>343</epage><pages>327-343</pages><issn>0021-9150</issn><eissn>1879-1484</eissn><abstract>In summary, we have presented evidence to support the hypoxic theory for the formation of atherosclerosis. More importantly, though, we have presented the following etiology for such hypoxia:
1.
(1) Oxygen transport is affected by plasma protein concentrations and in most humans probably decreases with age;
2.
(2) The result of hypoxia at the aortic lining is a degeneration of surface features which results in increased cellular permeability; and
3.
(3) The interior structure of the vessel is further disorganized due to the influx of lipids and other plasmatic matter. This in turn accelerates oxygen demand and augments hypoxia.
These ideas concerning the effects of proteins on oxygen transport, as well as the importance of the diffusion resistance of blood plasma, provide strong indications of a comprehensive mechanism for the occurrence of atherosclerosis and other vascular changes associated with aging.</abstract><cop>Ireland</cop><pub>Elsevier Ireland Ltd</pub><pmid>4115210</pmid><doi>10.1016/0021-9150(72)90022-6</doi><tpages>17</tpages></addata></record> |
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| ispartof | Atherosclerosis, 1972-05, Vol.15 (3), p.327-343 |
| issn | 0021-9150 1879-1484 |
| language | eng |
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| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | Age Factors Animals Aorta - cytology Aortic Diseases - blood Arteriosclerosis - blood Arteriosclerosis - etiology Atherosclerosis Biological Transport Blood Proteins - metabolism Cholesterol Diet, Atherogenic Dietary Fats Diffusion Epithelial Cells Fibrinogen - metabolism gamma-Globulins - metabolism gamma-Globulins - pharmacology Humans Hypoxia Hypoxia - complications Injections, Intramuscular Microscopy, Electron Oxygen - blood Permeability Plasma proteins Rabbit aorta Rabbits Scanning electron microscopy Serum Albumin - metabolism Serum Albumin - pharmacology |
| title | Plasma proteins, oxygen transport and atherosclerosis |
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