Characterization of the human nucleus pulposus cell phenotype and evaluation of novel marker gene expression to define adult stem cell differentiation

Objective Development of stem cell therapies for regenerating the nucleus pulposus (NP) are hindered by the lack of specific markers by which to distinguish NP cells from articular chondrocytes (ACs). The purpose of this study was to define the phenotype profile of human NP cells using gene expressi...

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Veröffentlicht in:	Arthritis & rheumatology (Hoboken, N.J.) N.J.), 2010-12, Vol.62 (12), p.3695-3705
Hauptverfasser:	Minogue, Ben M., Richardson, Stephen M., Zeef, Leo A. H., Freemont, Anthony J., Hoyland, Judith A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenylate cyclase Adult Stem Cells - metabolism Adult Stem Cells - pathology Biological and medical sciences Biomarkers - metabolism Bone marrow Calcium-Binding Proteins - metabolism Cartilage, Articular - metabolism Cartilage, Articular - pathology Cell Differentiation Cell differentiation, maturation, development, hematopoiesis Cell physiology Cells, Cultured Chondrocytes Collagen (type I) Differentiation Diseases of the osteoarticular system Female Forkhead Transcription Factors - metabolism Fundamental and applied biological sciences. Psychology Gels Gene expression Gene Expression Profiling Genotype & phenotype Humans Integrin-Binding Sialoprotein - metabolism Intervertebral Disc - metabolism Intervertebral Disc - pathology Intervertebral discs Male Medical sciences Mesenchymal Stromal Cells - metabolism Mesenchymal Stromal Cells - pathology Mesenchyme Middle Aged Molecular and cellular biology nucleus pulposus Paired Box Transcription Factors - metabolism Phenotype Polymerase chain reaction Stem cells Tissue engineering
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