Phosphine-catalyzed asymmetric additions of malonate esters to {gamma}-substituted allenoates and allenamides
Because carbonyl groups are ubiquitous in organic chemistry, the ability to synthesize functionalized carbonyl compounds, particularly enantioselectively, is an important objective. We have developed a straightforward and versatile method for catalytic asymmetric carbon-carbon bond formation at the...
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| Veröffentlicht in: | Proceedings of the National Academy of Sciences - PNAS 2010-11, Vol.107 (48), p.20652-20654 |
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| container_end_page | 20654 |
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| container_issue | 48 |
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| container_title | Proceedings of the National Academy of Sciences - PNAS |
| container_volume | 107 |
| creator | Sinisi, Riccardo Sun, Jianwei Fu, Gregory C |
| description | Because carbonyl groups are ubiquitous in organic chemistry, the ability to synthesize functionalized carbonyl compounds, particularly enantioselectively, is an important objective. We have developed a straightforward and versatile method for catalytic asymmetric carbon-carbon bond formation at the γ-position of carbonyl compounds, specifically, phosphine-catalyzed additions of malonate esters to γ-substituted allenoates and allenamides. Mechanistic studies have provided insight into the reaction pathway. |
| doi_str_mv | 10.1073/pnas.1003597107 |
| format | Article |
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| ispartof | Proceedings of the National Academy of Sciences - PNAS, 2010-11, Vol.107 (48), p.20652-20654 |
| issn | 0027-8424 1091-6490 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_815555664 |
| source | JSTOR Archive Collection A-Z Listing; PubMed Central; Alma/SFX Local Collection; Free Full-Text Journals in Chemistry |
| subjects | Carbon Catalysis Catalysts Chemical bonds Organic chemistry |
| title | Phosphine-catalyzed asymmetric additions of malonate esters to {gamma}-substituted allenoates and allenamides |
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