Antagonistic Effects of Ondansetron and Tramadol? A Randomized Placebo and Active Drug Controlled Study

Abstract Opposing effects of ondansetron and tramadol on the serotonin pathway have been suggested which possibly increase tramadol consumption and emesis when co-administered. In a randomized, double-blinded study, 179 patients received intravenous ondansetron, metoclopramide, or placebo for emesis...

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Veröffentlicht in:	The journal of pain 2010-12, Vol.11 (12), p.1274-1281
Hauptverfasser:	Rauers, Neele I, Stüber, Frank, Lee, Eun-Hae, Musshoff, Frank, Fimmers, Rolf, Barann, Martin, Stamer, Ulrike M
Format:	Artikel
Sprache:	eng
Schlagworte:	Analgesia Analgesia, Patient-Controlled Analgesics, Opioid - blood Analgesics, Opioid - therapeutic use Anesthesia & Perioperative Care Antiemetics - blood Antiemetics - therapeutic use Area Under Curve Cytochrome P-450 CYP2D6 - genetics Double-Blind Method Drug Interactions emesis Female Humans Male Metoclopramide - therapeutic use Middle Aged ondansetron Ondansetron - blood Ondansetron - therapeutic use Pain Medicine Postoperative Nausea and Vomiting - prevention & control Reverse Transcriptase Polymerase Chain Reaction serotonin tramadol Tramadol - blood Tramadol - therapeutic use
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