β-glucan from barley and its lipid-lowering capacity: a meta-analysis of randomized, controlled trials

Background/Objectives: To more precisely quantify the effect of barley β-glucan on blood lipid concentrations in humans and to examine the factors that could affect its efficacy. Subjects/Methods: Eleven eligible randomized clinical trials published from 1989 to 2008 were identified from nine databa...

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Veröffentlicht in:	European journal of clinical nutrition 2010-12, Vol.64 (12), p.1472-1480
Hauptverfasser:	AbuMweis, S.S, Jew, S, Ames, N.P
Format:	Artikel
Sprache:	eng
Schlagworte:	631/45/612/1191 692/700/565/2072 Barley beta-glucans beta-Glucans - therapeutic use Biological and medical sciences blood lipids Cholesterol Cholesterol, HDL - blood Cholesterol, LDL - blood Clinical Nutrition Clinical trials Confidence intervals Cross-Over Studies dose response Epidemiology Feeding. Feeding behavior Food consumption Food matrix Fundamental and applied biological sciences. Psychology Glucan Hordeum - chemistry human nutrition Humans Hypercholesterolemia - drug therapy Internal Medicine lipemic effect Lipids Low density lipoprotein Medical sciences Medicine Medicine & Public Health Meta-analysis Metabolic Diseases nutritional intervention original-article Phytotherapy Plant Preparations Public Health randomized clinical trials Randomized Controlled Trials as Topic Subgroups Triglycerides - blood Vertebrates: anatomy and physiology, studies on body, several organs or systems β-Glucan
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Zusammenfassung:	Background/Objectives: To more precisely quantify the effect of barley β-glucan on blood lipid concentrations in humans and to examine the factors that could affect its efficacy. Subjects/Methods: Eleven eligible randomized clinical trials published from 1989 to 2008 were identified from nine databases. Weighted mean effect sizes were calculated for net differences in lipid profile using a random effect model (RevMan 4.2). Results: Overall, barley and β-glucan isolated from barley lowered total and low-density lipoprotein (LDL) cholesterol concentrations by 0.30 mmol/l (95% confidence interval (CI): −0.39 to −0.21, P
ISSN:	0954-3007 1476-5640
DOI:	10.1038/ejcn.2010.178