Comparative Enzyme Immunoassay of Matrix Metalloproteinases-2, -7, -9 and Their Tissue Inhibitor-2 in Tumors and Plasma of Patients with Gastric Cancer
The content of matrix metalloproteinases (MMP) -2, -7, and -9 was significantly higher in tumors in comparison with the adjacent histologically intact gastric mucosa in 80, 70, and 72% patients with gastric cancer, respectively, the increase in the level of MMP tissue inhibitor-2 (TIMP-2) detected i...
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| Veröffentlicht in: | Bulletin of experimental biology and medicine 2009-12, Vol.148 (6), p.899-902 |
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| container_title | Bulletin of experimental biology and medicine |
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| creator | Gerstein, E. S Sini, Li Ryabov, A. B Dvorova, E. K Yurchenko, A. A Stilidi, I. S Kushlinskii, N. E Davydov, M. I |
| description | The content of matrix metalloproteinases (MMP) -2, -7, and -9 was significantly higher in tumors in comparison with the adjacent histologically intact gastric mucosa in 80, 70, and 72% patients with gastric cancer, respectively, the increase in the level of MMP tissue inhibitor-2 (TIMP-2) detected in 61% tumors was insignificant. Only plasma level of MMP-7 was elevated in primary patients in comparison with the control and positively correlated with the expression of this protein in the tumor. The concentration of MMP-7 was maximum in the blood of patients with tumor invasion in lymph vessels. These data suggest MMP-7 as a possible serological marker of gastric cancer. |
| doi_str_mv | 10.1007/s10517-010-0847-x |
| format | Article |
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| ispartof | Bulletin of experimental biology and medicine, 2009-12, Vol.148 (6), p.899-902 |
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| subjects | Adult Aged Biomedical and Life Sciences Biomedicine Cell Biology Female Humans Immunoenzyme Techniques - methods In Vitro Techniques Internal Medicine Laboratory Medicine Male Matrix Metalloproteinase 2 - blood Matrix Metalloproteinase 2 - metabolism Matrix Metalloproteinase 7 - blood Matrix Metalloproteinase 7 - metabolism Matrix Metalloproteinase 9 - blood Matrix Metalloproteinase 9 - metabolism matrix metalloproteinase tissue inhibitor-2 matrix metalloproteinase-2, matrix metalloproteinase-7, matrix metalloproteinase-9 Middle Aged Oncology Pathology stomach neoplasms Stomach Neoplasms - blood Stomach Neoplasms - enzymology Stomach Neoplasms - metabolism Tissue Inhibitor of Metalloproteinase-2 - blood Tissue Inhibitor of Metalloproteinase-2 - metabolism |
| title | Comparative Enzyme Immunoassay of Matrix Metalloproteinases-2, -7, -9 and Their Tissue Inhibitor-2 in Tumors and Plasma of Patients with Gastric Cancer |
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