The antitumour effect of {gamma}{delta} T-cells is enhanced by valproic acid-induced up-regulation of NKG2D ligands

The aim of this study wsa to evaluate the additive effect of valproic acid (VPA) to γδ T-cell cytotoxicity against bladder cancer cells. Human bladder cancer cell lines TCCSUP and 253J were treated with VPA and mRNA expression of natural killer group 2D (NKG2D) ligands was determined. The antitumour...

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Veröffentlicht in:	Anticancer research 2010-11, Vol.30 (11), p.4509-4513
Hauptverfasser:	Suzuki, Toru, Terao, Shuji, Acharya, Bishnu, Naoe, Michio, Yamamoto, Shingo, Okamura, Haruki, Gotoh, Akinobu
Format:	Artikel
Sprache:	eng
Schlagworte:	Blotting, Western Cell Line, Tumor Cell Proliferation Cytotoxicity, Immunologic GABA Agents - pharmacology Gene Expression Regulation, Neoplastic - drug effects Histocompatibility Antigens Class I - genetics Histocompatibility Antigens Class I - metabolism Humans Killer Cells, Natural - drug effects Killer Cells, Natural - immunology Ligands NK Cell Lectin-Like Receptor Subfamily K - genetics NK Cell Lectin-Like Receptor Subfamily K - metabolism Receptors, Antigen, T-Cell, gamma-delta - metabolism Reverse Transcriptase Polymerase Chain Reaction RNA, Messenger - genetics T-Lymphocytes - physiology Urinary Bladder Neoplasms - immunology Urinary Bladder Neoplasms - pathology Urinary Bladder Neoplasms - therapy Valproic Acid - pharmacology
Online-Zugang:	Volltext
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