Natural Killer Cells and HLA-G Expression in the Basal Decidua of Human Placenta Adhesiva
Abstract Retained placenta is caused by abnormal adherence of the placenta to the uterine wall, leading to delayed expulsion of the placenta and causing postpartum haemorrhage. The mildest form of retained placenta is the placenta adhesiva (PA), of which the cause is unknown. The aim of our study wa...
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| Veröffentlicht in: | Placenta (Eastbourne) 2010-12, Vol.31 (12), p.1078-1084 |
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| creator | van Beekhuizen, H.J Joosten, I Lotgering, F.K Bulten, J van Kempen, L.C |
| description | Abstract Retained placenta is caused by abnormal adherence of the placenta to the uterine wall, leading to delayed expulsion of the placenta and causing postpartum haemorrhage. The mildest form of retained placenta is the placenta adhesiva (PA), of which the cause is unknown. The aim of our study was to explore possible differences in immune response in the basal decidua between PA and control placentas (CP). We performed a descriptive analysis of immunohistochemical differences in 17 PA and 10 CP. Our results show that in PA the amount of uterine natural killer (uNK) cells is significantly reduced (0.2 uNK cell/standardised area) as compared to CP (9.8 uNK cell/standardised area, p < 0.001) whereas the number of trophoblast cells and the expression of HLA-G by trophoblast are similar in the decidua of PA and CP. We speculate that adequate numbers of uNK cells in the basal decidua are needed for normal expulsion of the placenta. |
| doi_str_mv | 10.1016/j.placenta.2010.09.016 |
| format | Article |
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The mildest form of retained placenta is the placenta adhesiva (PA), of which the cause is unknown. The aim of our study was to explore possible differences in immune response in the basal decidua between PA and control placentas (CP). We performed a descriptive analysis of immunohistochemical differences in 17 PA and 10 CP. Our results show that in PA the amount of uterine natural killer (uNK) cells is significantly reduced (0.2 uNK cell/standardised area) as compared to CP (9.8 uNK cell/standardised area, p < 0.001) whereas the number of trophoblast cells and the expression of HLA-G by trophoblast are similar in the decidua of PA and CP. We speculate that adequate numbers of uNK cells in the basal decidua are needed for normal expulsion of the placenta.</description><identifier>ISSN: 0143-4004</identifier><identifier>EISSN: 1532-3102</identifier><identifier>DOI: 10.1016/j.placenta.2010.09.016</identifier><identifier>PMID: 20952056</identifier><identifier>CODEN: PLACDF</identifier><language>eng</language><publisher>Kidlington: Elsevier Ltd</publisher><subject>Adult ; Basal decidua ; Biological and medical sciences ; Cell Proliferation ; Embryology: invertebrates and vertebrates. Teratology ; Female ; Fundamental and applied biological sciences. Psychology ; Histocompatibility Antigens Class I - metabolism ; HLA Antigens - metabolism ; HLA-G Antigens ; Humans ; Internal Medicine ; Killer Cells, Natural - pathology ; Myometrium ; Obstetrics and Gynecology ; Placenta - pathology ; Placenta, Retained - immunology ; Placenta, Retained - metabolism ; Placenta, Retained - pathology ; Pregnancy ; Retained placenta ; Trophoblast ; Uterine natural killer cells</subject><ispartof>Placenta (Eastbourne), 2010-12, Vol.31 (12), p.1078-1084</ispartof><rights>Elsevier Ltd</rights><rights>2010 Elsevier Ltd</rights><rights>2015 INIST-CNRS</rights><rights>Copyright © 2010 Elsevier Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c452t-2b7b4c7c104be2a62d4a58601006715448bbe670d22a23c4f9e6538c0364795d3</citedby><cites>FETCH-LOGICAL-c452t-2b7b4c7c104be2a62d4a58601006715448bbe670d22a23c4f9e6538c0364795d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.placenta.2010.09.016$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,777,781,3537,27905,27906,45976</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=23630669$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20952056$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>van Beekhuizen, H.J</creatorcontrib><creatorcontrib>Joosten, I</creatorcontrib><creatorcontrib>Lotgering, F.K</creatorcontrib><creatorcontrib>Bulten, J</creatorcontrib><creatorcontrib>van Kempen, L.C</creatorcontrib><title>Natural Killer Cells and HLA-G Expression in the Basal Decidua of Human Placenta Adhesiva</title><title>Placenta (Eastbourne)</title><addtitle>Placenta</addtitle><description>Abstract Retained placenta is caused by abnormal adherence of the placenta to the uterine wall, leading to delayed expulsion of the placenta and causing postpartum haemorrhage. The mildest form of retained placenta is the placenta adhesiva (PA), of which the cause is unknown. The aim of our study was to explore possible differences in immune response in the basal decidua between PA and control placentas (CP). We performed a descriptive analysis of immunohistochemical differences in 17 PA and 10 CP. Our results show that in PA the amount of uterine natural killer (uNK) cells is significantly reduced (0.2 uNK cell/standardised area) as compared to CP (9.8 uNK cell/standardised area, p < 0.001) whereas the number of trophoblast cells and the expression of HLA-G by trophoblast are similar in the decidua of PA and CP. We speculate that adequate numbers of uNK cells in the basal decidua are needed for normal expulsion of the placenta.</description><subject>Adult</subject><subject>Basal decidua</subject><subject>Biological and medical sciences</subject><subject>Cell Proliferation</subject><subject>Embryology: invertebrates and vertebrates. Teratology</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Histocompatibility Antigens Class I - metabolism</subject><subject>HLA Antigens - metabolism</subject><subject>HLA-G Antigens</subject><subject>Humans</subject><subject>Internal Medicine</subject><subject>Killer Cells, Natural - pathology</subject><subject>Myometrium</subject><subject>Obstetrics and Gynecology</subject><subject>Placenta - pathology</subject><subject>Placenta, Retained - immunology</subject><subject>Placenta, Retained - metabolism</subject><subject>Placenta, Retained - pathology</subject><subject>Pregnancy</subject><subject>Retained placenta</subject><subject>Trophoblast</subject><subject>Uterine natural killer cells</subject><issn>0143-4004</issn><issn>1532-3102</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkktvEzEQgC0EomnhL1S-IE4bxs_NXhAhtA0iAiTgwMny2rOqw8Yb7N2K_nscJQWJC6eRRt-8Pg0hlwzmDJh-tZ3ve-swjnbOoSShmZf0IzJjSvBKMOCPyQyYFJUEkGfkPOctADSS8afkjEOjOCg9I98_2nFKtqcfQt9joivs-0xt9HS9WVY39OrXPmHOYYg0RDreIn1rc8HfoQt-snTo6Hra2Ug_n9ahS3-LOdzZZ-RJZ_uMz0_xgny7vvq6WlebTzfvV8tN5aTiY8XbupWudgxki9xq7qVVC11uAl0zJeWibVHX4Dm3XDjZNaiVWDgQWtaN8uKCvDz23afh54R5NLuQXTnDRhymbBZMKdlIpQupj6RLQ84JO7NPYWfTvWFgDlbN1jxYNQerBhpT0qXw8jRianfo_5Q9aCzAixNgs7N9l2x0If_lhBagdVO4N0cOi5C7gMlkFzA69CGhG40fwv93ef1PC9eHGMrUH3iPeTtMKRbdhpnMDZgvhx84vEDxWZSxRvwGgMGq1g</recordid><startdate>20101201</startdate><enddate>20101201</enddate><creator>van Beekhuizen, H.J</creator><creator>Joosten, I</creator><creator>Lotgering, F.K</creator><creator>Bulten, J</creator><creator>van Kempen, L.C</creator><general>Elsevier Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20101201</creationdate><title>Natural Killer Cells and HLA-G Expression in the Basal Decidua of Human Placenta Adhesiva</title><author>van Beekhuizen, H.J ; Joosten, I ; Lotgering, F.K ; Bulten, J ; van Kempen, L.C</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c452t-2b7b4c7c104be2a62d4a58601006715448bbe670d22a23c4f9e6538c0364795d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Adult</topic><topic>Basal decidua</topic><topic>Biological and medical sciences</topic><topic>Cell Proliferation</topic><topic>Embryology: invertebrates and vertebrates. Teratology</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Histocompatibility Antigens Class I - metabolism</topic><topic>HLA Antigens - metabolism</topic><topic>HLA-G Antigens</topic><topic>Humans</topic><topic>Internal Medicine</topic><topic>Killer Cells, Natural - pathology</topic><topic>Myometrium</topic><topic>Obstetrics and Gynecology</topic><topic>Placenta - pathology</topic><topic>Placenta, Retained - immunology</topic><topic>Placenta, Retained - metabolism</topic><topic>Placenta, Retained - pathology</topic><topic>Pregnancy</topic><topic>Retained placenta</topic><topic>Trophoblast</topic><topic>Uterine natural killer cells</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>van Beekhuizen, H.J</creatorcontrib><creatorcontrib>Joosten, I</creatorcontrib><creatorcontrib>Lotgering, F.K</creatorcontrib><creatorcontrib>Bulten, J</creatorcontrib><creatorcontrib>van Kempen, L.C</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Placenta (Eastbourne)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>van Beekhuizen, H.J</au><au>Joosten, I</au><au>Lotgering, F.K</au><au>Bulten, J</au><au>van Kempen, L.C</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Natural Killer Cells and HLA-G Expression in the Basal Decidua of Human Placenta Adhesiva</atitle><jtitle>Placenta (Eastbourne)</jtitle><addtitle>Placenta</addtitle><date>2010-12-01</date><risdate>2010</risdate><volume>31</volume><issue>12</issue><spage>1078</spage><epage>1084</epage><pages>1078-1084</pages><issn>0143-4004</issn><eissn>1532-3102</eissn><coden>PLACDF</coden><abstract>Abstract Retained placenta is caused by abnormal adherence of the placenta to the uterine wall, leading to delayed expulsion of the placenta and causing postpartum haemorrhage. The mildest form of retained placenta is the placenta adhesiva (PA), of which the cause is unknown. The aim of our study was to explore possible differences in immune response in the basal decidua between PA and control placentas (CP). We performed a descriptive analysis of immunohistochemical differences in 17 PA and 10 CP. Our results show that in PA the amount of uterine natural killer (uNK) cells is significantly reduced (0.2 uNK cell/standardised area) as compared to CP (9.8 uNK cell/standardised area, p < 0.001) whereas the number of trophoblast cells and the expression of HLA-G by trophoblast are similar in the decidua of PA and CP. We speculate that adequate numbers of uNK cells in the basal decidua are needed for normal expulsion of the placenta.</abstract><cop>Kidlington</cop><pub>Elsevier Ltd</pub><pmid>20952056</pmid><doi>10.1016/j.placenta.2010.09.016</doi><tpages>7</tpages></addata></record> |
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| subjects | Adult Basal decidua Biological and medical sciences Cell Proliferation Embryology: invertebrates and vertebrates. Teratology Female Fundamental and applied biological sciences. Psychology Histocompatibility Antigens Class I - metabolism HLA Antigens - metabolism HLA-G Antigens Humans Internal Medicine Killer Cells, Natural - pathology Myometrium Obstetrics and Gynecology Placenta - pathology Placenta, Retained - immunology Placenta, Retained - metabolism Placenta, Retained - pathology Pregnancy Retained placenta Trophoblast Uterine natural killer cells |
| title | Natural Killer Cells and HLA-G Expression in the Basal Decidua of Human Placenta Adhesiva |
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