Recommending flavanols and procyanidins for cardiovascular health: Current knowledge and future needs
Data on the potential health benefits of dietary flavanols and procyanidins, especially in the context of cardiovascular health, are considerable and continue to accumulate. Significant progress has been made in flavanol analytics and the creation of phytonutrient-content food databases, and novel d...
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| Veröffentlicht in: | Molecular aspects of medicine 2010-12, Vol.31 (6), p.546-557 |
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| creator | Schroeter, Hagen Heiss, Christian Spencer, Jeremy P.E. Keen, Carl L. Lupton, Joanne R. Schmitz, Harold H. |
| description | Data on the potential health benefits of dietary flavanols and procyanidins, especially in the context of cardiovascular health, are considerable and continue to accumulate. Significant progress has been made in flavanol analytics and the creation of phytonutrient-content food databases, and novel data emanated from epidemiological investigations as well as dietary intervention studies. However, a comprehensive understanding of the pharmacological properties of flavanols and procyanidins, including their precise mechanisms of action in vivo, and a conclusive, consensus-based accreditation of a causal relationship between intake and health benefits in the context of primary and secondary cardiovascular disease prevention is still outstanding. Thus, the objective of this review is to identify and discuss key questions and gaps that will need to be addressed in order to conclusively demonstrate whether or not dietary flavanols and procyanidins have a role in preventing, delaying the onset of, or treating cardiovascular diseases, and thus improving human life expectancy and quality of life. |
| doi_str_mv | 10.1016/j.mam.2010.09.008 |
| format | Article |
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Significant progress has been made in flavanol analytics and the creation of phytonutrient-content food databases, and novel data emanated from epidemiological investigations as well as dietary intervention studies. However, a comprehensive understanding of the pharmacological properties of flavanols and procyanidins, including their precise mechanisms of action in vivo, and a conclusive, consensus-based accreditation of a causal relationship between intake and health benefits in the context of primary and secondary cardiovascular disease prevention is still outstanding. Thus, the objective of this review is to identify and discuss key questions and gaps that will need to be addressed in order to conclusively demonstrate whether or not dietary flavanols and procyanidins have a role in preventing, delaying the onset of, or treating cardiovascular diseases, and thus improving human life expectancy and quality of life.</description><identifier>ISSN: 0098-2997</identifier><identifier>EISSN: 1872-9452</identifier><identifier>DOI: 10.1016/j.mam.2010.09.008</identifier><identifier>PMID: 20854838</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>Cardiovascular disease ; Cardiovascular Diseases - prevention & control ; Cocoa ; Diet ; Epicatechin ; Flavonoids - administration & dosage ; Forecasting ; Health Behavior ; Health Knowledge, Attitudes, Practice ; Health Planning Guidelines ; Humans ; Nutrition ; Phytonutrient ; Proanthocyanidins ; Proanthocyanidins - administration & dosage ; Tea</subject><ispartof>Molecular aspects of medicine, 2010-12, Vol.31 (6), p.546-557</ispartof><rights>2010 Elsevier Ltd</rights><rights>Copyright © 2010 Elsevier Ltd. 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Significant progress has been made in flavanol analytics and the creation of phytonutrient-content food databases, and novel data emanated from epidemiological investigations as well as dietary intervention studies. However, a comprehensive understanding of the pharmacological properties of flavanols and procyanidins, including their precise mechanisms of action in vivo, and a conclusive, consensus-based accreditation of a causal relationship between intake and health benefits in the context of primary and secondary cardiovascular disease prevention is still outstanding. Thus, the objective of this review is to identify and discuss key questions and gaps that will need to be addressed in order to conclusively demonstrate whether or not dietary flavanols and procyanidins have a role in preventing, delaying the onset of, or treating cardiovascular diseases, and thus improving human life expectancy and quality of life.</description><subject>Cardiovascular disease</subject><subject>Cardiovascular Diseases - prevention & control</subject><subject>Cocoa</subject><subject>Diet</subject><subject>Epicatechin</subject><subject>Flavonoids - administration & dosage</subject><subject>Forecasting</subject><subject>Health Behavior</subject><subject>Health Knowledge, Attitudes, Practice</subject><subject>Health Planning Guidelines</subject><subject>Humans</subject><subject>Nutrition</subject><subject>Phytonutrient</subject><subject>Proanthocyanidins</subject><subject>Proanthocyanidins - administration & dosage</subject><subject>Tea</subject><issn>0098-2997</issn><issn>1872-9452</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE1P7CAUhonR6PjxA9wYdq46Ai0teFdm4ldiYmJ0TSgclLEFhXaM_96O43XpipzwvG_OeRA6pmROCa3PlvNe93NGppnIOSFiC82oaFghK8620YwQKQomZbOH9nNeEkJ5U_NdtMeI4JUoxQzBA5jY9xCsD8_YdXqlQ-wy1sHitxTNpw5--srYxYSNTtbHlc5m7HTCL6C74eUcL8aUIAz4NcSPDuwzfKfdOIwJcACw-RDtON1lOPp5D9DT1eXj4qa4u7--XVzcFaaUfCjKkrQCmhZKZqlrnakaVjFgWoLTjhHtamnrhgnLGt5ywQ0VpGRV7Qx13LHyAJ1ueqfV30fIg-p9NtB1OkAcsxKU80oysSbphjQp5pzAqbfke50-FSVqLVct1SRXreUqItUkd8qc_LSPbQ_2N_Hf5gT82wAw3bjykFQ2HoIB6xOYQdno_6j_Ar4FjC4</recordid><startdate>201012</startdate><enddate>201012</enddate><creator>Schroeter, Hagen</creator><creator>Heiss, Christian</creator><creator>Spencer, Jeremy P.E.</creator><creator>Keen, Carl L.</creator><creator>Lupton, Joanne R.</creator><creator>Schmitz, Harold H.</creator><general>Elsevier Ltd</general><scope>6I.</scope><scope>AAFTH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201012</creationdate><title>Recommending flavanols and procyanidins for cardiovascular health: Current knowledge and future needs</title><author>Schroeter, Hagen ; Heiss, Christian ; Spencer, Jeremy P.E. ; Keen, Carl L. ; Lupton, Joanne R. ; Schmitz, Harold H.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c395t-330b8e7be32d1fbfc47242e2a9efaf20af69d6728d275b585c1803246fc1f5f23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Cardiovascular disease</topic><topic>Cardiovascular Diseases - prevention & control</topic><topic>Cocoa</topic><topic>Diet</topic><topic>Epicatechin</topic><topic>Flavonoids - administration & dosage</topic><topic>Forecasting</topic><topic>Health Behavior</topic><topic>Health Knowledge, Attitudes, Practice</topic><topic>Health Planning Guidelines</topic><topic>Humans</topic><topic>Nutrition</topic><topic>Phytonutrient</topic><topic>Proanthocyanidins</topic><topic>Proanthocyanidins - administration & dosage</topic><topic>Tea</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Schroeter, Hagen</creatorcontrib><creatorcontrib>Heiss, Christian</creatorcontrib><creatorcontrib>Spencer, Jeremy P.E.</creatorcontrib><creatorcontrib>Keen, Carl L.</creatorcontrib><creatorcontrib>Lupton, Joanne R.</creatorcontrib><creatorcontrib>Schmitz, Harold H.</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Molecular aspects of medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Schroeter, Hagen</au><au>Heiss, Christian</au><au>Spencer, Jeremy P.E.</au><au>Keen, Carl L.</au><au>Lupton, Joanne R.</au><au>Schmitz, Harold H.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Recommending flavanols and procyanidins for cardiovascular health: Current knowledge and future needs</atitle><jtitle>Molecular aspects of medicine</jtitle><addtitle>Mol Aspects Med</addtitle><date>2010-12</date><risdate>2010</risdate><volume>31</volume><issue>6</issue><spage>546</spage><epage>557</epage><pages>546-557</pages><issn>0098-2997</issn><eissn>1872-9452</eissn><abstract>Data on the potential health benefits of dietary flavanols and procyanidins, especially in the context of cardiovascular health, are considerable and continue to accumulate. 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| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Cardiovascular disease Cardiovascular Diseases - prevention & control Cocoa Diet Epicatechin Flavonoids - administration & dosage Forecasting Health Behavior Health Knowledge, Attitudes, Practice Health Planning Guidelines Humans Nutrition Phytonutrient Proanthocyanidins Proanthocyanidins - administration & dosage Tea |
| title | Recommending flavanols and procyanidins for cardiovascular health: Current knowledge and future needs |
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