IKK antagonizes activation-induced cell death of CD4 + T cells in aged mice via inhibition of JNK activation

T cell dysfunction is the primary immunologic abnormality associated with aging. Many age-related defects stem from a decline in CD4 + T cell function. Resistance of aged CD4 + T cells to apoptosis is associated with autoimmune and infectious diseases. Previous studies suggest that IκB kinase (IKK)...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Molecular immunology 2010-11, Vol.48 (1-3), p.287-293
Hauptverfasser:	Deng, Hongbin, Mao, Genxiang, Zhang, Jingpu, Wang, Zhen, Li, Diandong
Format:	Artikel
Sprache:	eng
Schlagworte:	Activation-induced cell death Aging Aging - physiology Animals Apoptosis - physiology c-Jun N-terminal protein kinase CD4-Positive T-Lymphocytes - metabolism DNA Fragmentation Enzyme Activation - physiology I-kappa B Kinase - metabolism Immunoblotting Immunoprecipitation IκB kinase MAP Kinase Kinase 4 - metabolism Mice Mice, Inbred C57BL Signal Transduction - physiology T lymphocytes
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!