Effects of prostaglandin F(2α) analogues on endothelin-1-induced impairment of rabbit ocular blood flow: comparison among tafluprost, travoprost, and latanoprost

We investigated the effects of prostaglandin F(2α) (PGF(2α)) analogues on the endothelin-1 (ET-1)-induced impairment of optic nerve head (ONH) blood flow and on ET-1-induced contraction in isolated ciliary artery segments. In male rabbits, one of four PGF(2α) analogues [0.0015% tafluprost, 0.0015% 1...

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Veröffentlicht in:	Experimental eye research 2010-12, Vol.91 (6), p.853-859
Hauptverfasser:	Kurashima, Hiroaki, Watabe, Hiroshi, Sato, Noriko, Abe, Sanae, Ishida, Naruhiro, Yoshitomi, Takeshi
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Topical Animals Antihypertensive Agents - pharmacology Blood Flow Velocity - drug effects Ciliary Arteries - physiology Cloprostenol - analogs & derivatives Cloprostenol - pharmacology Dinoprost - analogs & derivatives Endothelin-1 - antagonists & inhibitors Endothelin-1 - toxicity Isometric Contraction - drug effects Laser-Doppler Flowmetry Male Muscle, Smooth, Vascular - physiology Optic Disk - blood supply Prostaglandins F - pharmacology Prostaglandins F, Synthetic - pharmacology Rabbits Regional Blood Flow - drug effects Travoprost
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