Effect of Reishi polysaccharides on human stem/progenitor cells
The polysaccharide fraction of Ganoderma lucidum (F3) was found to benefit our health in many ways by influencing the activity of tissue stem/progenitor cells. In this study, F3 was found to promote the adipose tissue MSCs’ aggregation and chondrosphere formation, with the increase of CAM (N-CAM, I-...
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| Veröffentlicht in: | Bioorganic & medicinal chemistry 2010-12, Vol.18 (24), p.8583-8591 |
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| creator | Chen, Wan-Yu Yang, Wen-Bin Wong, Chi-Huey Shih, Daniel Tzu-Bi |
| description | The polysaccharide fraction of
Ganoderma lucidum (F3) was found to benefit our health in many ways by influencing the activity of tissue stem/progenitor cells. In this study, F3 was found to promote the adipose tissue MSCs’ aggregation and chondrosphere formation, with the increase of CAM (N-CAM, I-CAM) expressions and autokine (BMP-2, IL-11, and aggrecan) secretions, in an in vitro chondrogenesis assay. In a stem cell expansion culture, it possesses the thrombopoietin (TPO) and GM-CSF like functions to enhance the survival/renewal abilities of primitive hematopoietic stem/progenitor cells (HSCs). F3 was found to promote the dendrite growth of blood mononuclear cells (MNCs) and the expression of cell adhesion molecules in the formation of immature dendritic cells (DC). On the other hand, F3 exhibited inhibitory effects on blood endothelial progenitor (EPC) colony formation, with concomitant reduction of cell surface endoglin (CD105) and vascular endothelial growth factor receptor-3 (VEGFR-3) marker expressions, in the presence of angiogenic factors. A further cytokine array analysis revealed that F3 indeed inhibited the angiogenin synthesis and enhanced IL-1, MCP-1, MIP-1, RANTES, and GRO productions in the blood EPC derivation culture. Collectively, we have demonstrated that the polysaccharide fraction of
G. lucidum F3 exhibits cytokine and chemokine like functions which are beneficial to human tissue stem/progenitor cells by modulating their CAM expressions and biological activities. These findings provide us a better the observation that F3 glycopolysaccharides indeed possesses anti-angiogenic and immune-modulating functions and promotes hematopoietic stem/progenitor cell homing for better human tissue protection, reducing disease progression and health. |
| doi_str_mv | 10.1016/j.bmc.2010.10.016 |
| format | Article |
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Ganoderma lucidum (F3) was found to benefit our health in many ways by influencing the activity of tissue stem/progenitor cells. In this study, F3 was found to promote the adipose tissue MSCs’ aggregation and chondrosphere formation, with the increase of CAM (N-CAM, I-CAM) expressions and autokine (BMP-2, IL-11, and aggrecan) secretions, in an in vitro chondrogenesis assay. In a stem cell expansion culture, it possesses the thrombopoietin (TPO) and GM-CSF like functions to enhance the survival/renewal abilities of primitive hematopoietic stem/progenitor cells (HSCs). F3 was found to promote the dendrite growth of blood mononuclear cells (MNCs) and the expression of cell adhesion molecules in the formation of immature dendritic cells (DC). On the other hand, F3 exhibited inhibitory effects on blood endothelial progenitor (EPC) colony formation, with concomitant reduction of cell surface endoglin (CD105) and vascular endothelial growth factor receptor-3 (VEGFR-3) marker expressions, in the presence of angiogenic factors. A further cytokine array analysis revealed that F3 indeed inhibited the angiogenin synthesis and enhanced IL-1, MCP-1, MIP-1, RANTES, and GRO productions in the blood EPC derivation culture. Collectively, we have demonstrated that the polysaccharide fraction of
G. lucidum F3 exhibits cytokine and chemokine like functions which are beneficial to human tissue stem/progenitor cells by modulating their CAM expressions and biological activities. These findings provide us a better the observation that F3 glycopolysaccharides indeed possesses anti-angiogenic and immune-modulating functions and promotes hematopoietic stem/progenitor cell homing for better human tissue protection, reducing disease progression and health.</description><identifier>ISSN: 0968-0896</identifier><identifier>EISSN: 1464-3391</identifier><identifier>DOI: 10.1016/j.bmc.2010.10.016</identifier><identifier>PMID: 21055951</identifier><language>eng</language><publisher>Amsterdam: Elsevier Ltd</publisher><subject>Adipose Tissue - cytology ; Anti-angiogenesis ; Biological and medical sciences ; Cell Adhesion - drug effects ; Cell adhesion molecules ; Cell Adhesion Molecules - genetics ; Cytokines - genetics ; Gene Expression Regulation - drug effects ; General pharmacology ; Hematopoietic Stem Cells - drug effects ; Human tissue stem/progenitor cells ; Humans ; Immune defensive chemokines ; Medical sciences ; Pharmacognosy. Homeopathy. Health food ; Pharmacology. Drug treatments ; Polysaccharides - pharmacology ; Reishi - chemistry ; Reishi F3 polysaccharides</subject><ispartof>Bioorganic & medicinal chemistry, 2010-12, Vol.18 (24), p.8583-8591</ispartof><rights>2010 Elsevier Ltd</rights><rights>2015 INIST-CNRS</rights><rights>Copyright © 2010 Elsevier Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c382t-8ed7670a3fcf60c01897507a3fd73c4aafd8a4cbfdecbd32175b83c802fbe0a23</citedby><cites>FETCH-LOGICAL-c382t-8ed7670a3fcf60c01897507a3fd73c4aafd8a4cbfdecbd32175b83c802fbe0a23</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0968089610009387$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=23624437$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21055951$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Chen, Wan-Yu</creatorcontrib><creatorcontrib>Yang, Wen-Bin</creatorcontrib><creatorcontrib>Wong, Chi-Huey</creatorcontrib><creatorcontrib>Shih, Daniel Tzu-Bi</creatorcontrib><title>Effect of Reishi polysaccharides on human stem/progenitor cells</title><title>Bioorganic & medicinal chemistry</title><addtitle>Bioorg Med Chem</addtitle><description>The polysaccharide fraction of
Ganoderma lucidum (F3) was found to benefit our health in many ways by influencing the activity of tissue stem/progenitor cells. In this study, F3 was found to promote the adipose tissue MSCs’ aggregation and chondrosphere formation, with the increase of CAM (N-CAM, I-CAM) expressions and autokine (BMP-2, IL-11, and aggrecan) secretions, in an in vitro chondrogenesis assay. In a stem cell expansion culture, it possesses the thrombopoietin (TPO) and GM-CSF like functions to enhance the survival/renewal abilities of primitive hematopoietic stem/progenitor cells (HSCs). F3 was found to promote the dendrite growth of blood mononuclear cells (MNCs) and the expression of cell adhesion molecules in the formation of immature dendritic cells (DC). On the other hand, F3 exhibited inhibitory effects on blood endothelial progenitor (EPC) colony formation, with concomitant reduction of cell surface endoglin (CD105) and vascular endothelial growth factor receptor-3 (VEGFR-3) marker expressions, in the presence of angiogenic factors. A further cytokine array analysis revealed that F3 indeed inhibited the angiogenin synthesis and enhanced IL-1, MCP-1, MIP-1, RANTES, and GRO productions in the blood EPC derivation culture. Collectively, we have demonstrated that the polysaccharide fraction of
G. lucidum F3 exhibits cytokine and chemokine like functions which are beneficial to human tissue stem/progenitor cells by modulating their CAM expressions and biological activities. These findings provide us a better the observation that F3 glycopolysaccharides indeed possesses anti-angiogenic and immune-modulating functions and promotes hematopoietic stem/progenitor cell homing for better human tissue protection, reducing disease progression and health.</description><subject>Adipose Tissue - cytology</subject><subject>Anti-angiogenesis</subject><subject>Biological and medical sciences</subject><subject>Cell Adhesion - drug effects</subject><subject>Cell adhesion molecules</subject><subject>Cell Adhesion Molecules - genetics</subject><subject>Cytokines - genetics</subject><subject>Gene Expression Regulation - drug effects</subject><subject>General pharmacology</subject><subject>Hematopoietic Stem Cells - drug effects</subject><subject>Human tissue stem/progenitor cells</subject><subject>Humans</subject><subject>Immune defensive chemokines</subject><subject>Medical sciences</subject><subject>Pharmacognosy. Homeopathy. Health food</subject><subject>Pharmacology. Drug treatments</subject><subject>Polysaccharides - pharmacology</subject><subject>Reishi - chemistry</subject><subject>Reishi F3 polysaccharides</subject><issn>0968-0896</issn><issn>1464-3391</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE1r3DAQhkVoSDYfP6CX4kvJyZuRJdsyPZSwbNJAIBDas5BHo64Wf2wlu5B_H2122956GublmeHlYewjhyUHXt1ul22PywLe92VKTtiCy0rmQjT8A1tAU6kcVFOds4sYtwBQyIafsfOCQ1k2JV-wr2vnCKdsdNkL-bjx2W7sXqNB3JjgLcVsHLLN3JshixP1t7sw_qTBT2PIkLouXrFTZ7pI18d5yX7cr7-vvuVPzw-Pq7unHIUqplyRrasajHDoKkDgqqlLqNNua4HSGGeVkdg6S9haUfC6bJVABYVrCUwhLtnN4W8q8GumOOnex30DM9A4R614WcqykZBIfiAxjDEGcnoXfG_Cq-ag99r0Vidteq9tH6Uk3Xw6fp_bnuzfiz-eEvD5CJiIpnPBDOjjP05UhZSiTtyXA0fJxW9PQUf0NCBZH5JmbUf_nxpv0FOKkQ</recordid><startdate>20101215</startdate><enddate>20101215</enddate><creator>Chen, Wan-Yu</creator><creator>Yang, Wen-Bin</creator><creator>Wong, Chi-Huey</creator><creator>Shih, Daniel Tzu-Bi</creator><general>Elsevier Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20101215</creationdate><title>Effect of Reishi polysaccharides on human stem/progenitor cells</title><author>Chen, Wan-Yu ; Yang, Wen-Bin ; Wong, Chi-Huey ; Shih, Daniel Tzu-Bi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c382t-8ed7670a3fcf60c01897507a3fd73c4aafd8a4cbfdecbd32175b83c802fbe0a23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Adipose Tissue - cytology</topic><topic>Anti-angiogenesis</topic><topic>Biological and medical sciences</topic><topic>Cell Adhesion - drug effects</topic><topic>Cell adhesion molecules</topic><topic>Cell Adhesion Molecules - genetics</topic><topic>Cytokines - genetics</topic><topic>Gene Expression Regulation - drug effects</topic><topic>General pharmacology</topic><topic>Hematopoietic Stem Cells - drug effects</topic><topic>Human tissue stem/progenitor cells</topic><topic>Humans</topic><topic>Immune defensive chemokines</topic><topic>Medical sciences</topic><topic>Pharmacognosy. Homeopathy. Health food</topic><topic>Pharmacology. Drug treatments</topic><topic>Polysaccharides - pharmacology</topic><topic>Reishi - chemistry</topic><topic>Reishi F3 polysaccharides</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Chen, Wan-Yu</creatorcontrib><creatorcontrib>Yang, Wen-Bin</creatorcontrib><creatorcontrib>Wong, Chi-Huey</creatorcontrib><creatorcontrib>Shih, Daniel Tzu-Bi</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Bioorganic & medicinal chemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Chen, Wan-Yu</au><au>Yang, Wen-Bin</au><au>Wong, Chi-Huey</au><au>Shih, Daniel Tzu-Bi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of Reishi polysaccharides on human stem/progenitor cells</atitle><jtitle>Bioorganic & medicinal chemistry</jtitle><addtitle>Bioorg Med Chem</addtitle><date>2010-12-15</date><risdate>2010</risdate><volume>18</volume><issue>24</issue><spage>8583</spage><epage>8591</epage><pages>8583-8591</pages><issn>0968-0896</issn><eissn>1464-3391</eissn><abstract>The polysaccharide fraction of
Ganoderma lucidum (F3) was found to benefit our health in many ways by influencing the activity of tissue stem/progenitor cells. In this study, F3 was found to promote the adipose tissue MSCs’ aggregation and chondrosphere formation, with the increase of CAM (N-CAM, I-CAM) expressions and autokine (BMP-2, IL-11, and aggrecan) secretions, in an in vitro chondrogenesis assay. In a stem cell expansion culture, it possesses the thrombopoietin (TPO) and GM-CSF like functions to enhance the survival/renewal abilities of primitive hematopoietic stem/progenitor cells (HSCs). F3 was found to promote the dendrite growth of blood mononuclear cells (MNCs) and the expression of cell adhesion molecules in the formation of immature dendritic cells (DC). On the other hand, F3 exhibited inhibitory effects on blood endothelial progenitor (EPC) colony formation, with concomitant reduction of cell surface endoglin (CD105) and vascular endothelial growth factor receptor-3 (VEGFR-3) marker expressions, in the presence of angiogenic factors. A further cytokine array analysis revealed that F3 indeed inhibited the angiogenin synthesis and enhanced IL-1, MCP-1, MIP-1, RANTES, and GRO productions in the blood EPC derivation culture. Collectively, we have demonstrated that the polysaccharide fraction of
G. lucidum F3 exhibits cytokine and chemokine like functions which are beneficial to human tissue stem/progenitor cells by modulating their CAM expressions and biological activities. These findings provide us a better the observation that F3 glycopolysaccharides indeed possesses anti-angiogenic and immune-modulating functions and promotes hematopoietic stem/progenitor cell homing for better human tissue protection, reducing disease progression and health.</abstract><cop>Amsterdam</cop><pub>Elsevier Ltd</pub><pmid>21055951</pmid><doi>10.1016/j.bmc.2010.10.016</doi><tpages>9</tpages></addata></record> |
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| subjects | Adipose Tissue - cytology Anti-angiogenesis Biological and medical sciences Cell Adhesion - drug effects Cell adhesion molecules Cell Adhesion Molecules - genetics Cytokines - genetics Gene Expression Regulation - drug effects General pharmacology Hematopoietic Stem Cells - drug effects Human tissue stem/progenitor cells Humans Immune defensive chemokines Medical sciences Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments Polysaccharides - pharmacology Reishi - chemistry Reishi F3 polysaccharides |
| title | Effect of Reishi polysaccharides on human stem/progenitor cells |
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