Probiotic preparation reduces the faecal water genotoxicity in chickens fed with aflatoxin B1 contaminated fodder
The aim of the study was to evaluate the influence of a probiotic preparation on the genotoxicity of faecal water of broiler chickens fed with a fodder contaminated with aflatoxin B 1 (AFB 1) at 1 or 5 mg per kg. Human blood lymphocytes were exposed to chicken’s faecal water samples and DNA damage w...
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| Veröffentlicht in: | Research in veterinary science 2010-12, Vol.89 (3), p.391-395 |
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| creator | Slizewska, Katarzyna Nowak, Adriana Libudzisz, Zdzislawa Blasiak, Janusz |
| description | The aim of the study was to evaluate the influence of a probiotic preparation on the genotoxicity of faecal water of broiler chickens fed with a fodder contaminated with aflatoxin B
1 (AFB
1) at 1 or 5
mg per kg. Human blood lymphocytes were exposed to chicken’s faecal water samples and DNA damage was measured using the comet assay. Genotoxicity of faecal water did not depend on the AFB
1 concentration in the fodder. The mean DNA damage, measured as the percentage of DNA in the tail of the comets, for chickens fed with fodder with AFB
1 at 1
mg/kg was 16.80
±
0.66, at 5
mg/kg – 16.73
±
1.51 and in the controls – 12.79
±
0.66. The supplementation of fodder with the probiotic preparation decreased the extent of DNA damage to 10.02
±
0.39 for 1
mg/kg AFB
1 and to 11.89
±
0.72 for 5
mg/kg. |
| doi_str_mv | 10.1016/j.rvsc.2010.04.004 |
| format | Article |
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1 (AFB
1) at 1 or 5
mg per kg. Human blood lymphocytes were exposed to chicken’s faecal water samples and DNA damage was measured using the comet assay. Genotoxicity of faecal water did not depend on the AFB
1 concentration in the fodder. The mean DNA damage, measured as the percentage of DNA in the tail of the comets, for chickens fed with fodder with AFB
1 at 1
mg/kg was 16.80
±
0.66, at 5
mg/kg – 16.73
±
1.51 and in the controls – 12.79
±
0.66. The supplementation of fodder with the probiotic preparation decreased the extent of DNA damage to 10.02
±
0.39 for 1
mg/kg AFB
1 and to 11.89
±
0.72 for 5
mg/kg.</description><identifier>ISSN: 0034-5288</identifier><identifier>EISSN: 1532-2661</identifier><identifier>DOI: 10.1016/j.rvsc.2010.04.004</identifier><identifier>PMID: 20435327</identifier><language>eng</language><publisher>England: Elsevier India Pvt Ltd</publisher><subject>Aflatoxin B 1 ; aflatoxin B1 ; Aflatoxin B1 - toxicity ; Algae ; Animal Feed - adverse effects ; Animal Feed - microbiology ; Animal Husbandry - methods ; Animals ; Bacteria ; Carcinogens ; Chicken ; chickens ; Chickens - physiology ; Comet Assay - veterinary ; Contamination ; Deoxyribonucleic acid ; Dietary Supplements ; DNA ; DNA damage ; DNA Damage - drug effects ; DNA Damage - genetics ; Economic justification ; feces ; Feces - microbiology ; feed contamination ; Feeds ; Female ; Fodder ; Food contamination & poisoning ; genotoxicity ; human cell lines ; Humans ; Lymphocytes ; Lymphocytes - drug effects ; Metabolites ; Microbiology ; Microorganisms ; Mutagenicity Tests - veterinary ; Poultry Diseases - prevention & control ; poultry feeding ; Probiotics ; Probiotics - therapeutic use ; Raw materials ; Toxins ; Veterinary medicine</subject><ispartof>Research in veterinary science, 2010-12, Vol.89 (3), p.391-395</ispartof><rights>2010 Elsevier Ltd</rights><rights>Copyright © 2010 Elsevier Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c439t-21fa80c6fc052732bc8ce66f7f3ba8c12edff939a720afdf481143535932b48f3</citedby><cites>FETCH-LOGICAL-c439t-21fa80c6fc052732bc8ce66f7f3ba8c12edff939a720afdf481143535932b48f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0034528810001049$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3536,27903,27904,65309</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20435327$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Slizewska, Katarzyna</creatorcontrib><creatorcontrib>Nowak, Adriana</creatorcontrib><creatorcontrib>Libudzisz, Zdzislawa</creatorcontrib><creatorcontrib>Blasiak, Janusz</creatorcontrib><title>Probiotic preparation reduces the faecal water genotoxicity in chickens fed with aflatoxin B1 contaminated fodder</title><title>Research in veterinary science</title><addtitle>Res Vet Sci</addtitle><description>The aim of the study was to evaluate the influence of a probiotic preparation on the genotoxicity of faecal water of broiler chickens fed with a fodder contaminated with aflatoxin B
1 (AFB
1) at 1 or 5
mg per kg. Human blood lymphocytes were exposed to chicken’s faecal water samples and DNA damage was measured using the comet assay. Genotoxicity of faecal water did not depend on the AFB
1 concentration in the fodder. The mean DNA damage, measured as the percentage of DNA in the tail of the comets, for chickens fed with fodder with AFB
1 at 1
mg/kg was 16.80
±
0.66, at 5
mg/kg – 16.73
±
1.51 and in the controls – 12.79
±
0.66. The supplementation of fodder with the probiotic preparation decreased the extent of DNA damage to 10.02
±
0.39 for 1
mg/kg AFB
1 and to 11.89
±
0.72 for 5
mg/kg.</description><subject>Aflatoxin B 1</subject><subject>aflatoxin B1</subject><subject>Aflatoxin B1 - toxicity</subject><subject>Algae</subject><subject>Animal Feed - adverse effects</subject><subject>Animal Feed - microbiology</subject><subject>Animal Husbandry - methods</subject><subject>Animals</subject><subject>Bacteria</subject><subject>Carcinogens</subject><subject>Chicken</subject><subject>chickens</subject><subject>Chickens - physiology</subject><subject>Comet Assay - veterinary</subject><subject>Contamination</subject><subject>Deoxyribonucleic acid</subject><subject>Dietary Supplements</subject><subject>DNA</subject><subject>DNA damage</subject><subject>DNA Damage - drug effects</subject><subject>DNA Damage - genetics</subject><subject>Economic justification</subject><subject>feces</subject><subject>Feces - microbiology</subject><subject>feed contamination</subject><subject>Feeds</subject><subject>Female</subject><subject>Fodder</subject><subject>Food contamination & poisoning</subject><subject>genotoxicity</subject><subject>human cell lines</subject><subject>Humans</subject><subject>Lymphocytes</subject><subject>Lymphocytes - drug effects</subject><subject>Metabolites</subject><subject>Microbiology</subject><subject>Microorganisms</subject><subject>Mutagenicity Tests - veterinary</subject><subject>Poultry Diseases - prevention & control</subject><subject>poultry feeding</subject><subject>Probiotics</subject><subject>Probiotics - therapeutic use</subject><subject>Raw materials</subject><subject>Toxins</subject><subject>Veterinary medicine</subject><issn>0034-5288</issn><issn>1532-2661</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqF0TtvFDEQB3ALgcgR-AIUYImCao_xY18STYh4SZFAgtSWzx7nfOzZF9ubkG-PVxcoKKCyZP1mNDN_Qp4zWDNg3ZvdOt1ks-ZQP0CuAeQDsmKt4A3vOvaQrACEbFo-DCfkSc47qIKx_jE54SBFdf2KXH9NceNj8YYeEh500sXHQBPa2WCmZYvUaTR6ore6YKJXGGKJP73x5Y76QM3Wmx8YMnVo6a0vW6rdpBcR6DtGTQxF732otZa6aC2mp-SR01PGZ_fvKbn88P77-afm4svHz-dnF42RYiwNZ04PYDpnoOW94BszGOw61zux0YNhHK1zoxh1z0E76-TA2LJUO1YrBydOyetj30OK1zPmovY-G5wmHTDOWQ2sbaUQfftf2XccBId-rPLVX3IX5xTqGoqBaEEC57wqflQmxZwTOnVIfq_TXUVqSU7t1JKcWpJTIFXNpRa9uG89b_Zo_5T8jqqCl0fgdFT6KvmsLr_VDgLYCF3LluneHgXWs954TCobj8Gg9QlNUTb6f03wCw3Ms5g</recordid><startdate>20101201</startdate><enddate>20101201</enddate><creator>Slizewska, Katarzyna</creator><creator>Nowak, Adriana</creator><creator>Libudzisz, Zdzislawa</creator><creator>Blasiak, Janusz</creator><general>Elsevier India Pvt Ltd</general><general>Elsevier Limited</general><scope>FBQ</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QG</scope><scope>7QP</scope><scope>7QR</scope><scope>7T5</scope><scope>7T7</scope><scope>7TK</scope><scope>7TM</scope><scope>7TO</scope><scope>7U7</scope><scope>7U9</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>K9.</scope><scope>M7N</scope><scope>P64</scope><scope>7X8</scope><scope>7QL</scope></search><sort><creationdate>20101201</creationdate><title>Probiotic preparation reduces the faecal water genotoxicity in chickens fed with aflatoxin B1 contaminated fodder</title><author>Slizewska, Katarzyna ; Nowak, Adriana ; Libudzisz, Zdzislawa ; Blasiak, Janusz</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c439t-21fa80c6fc052732bc8ce66f7f3ba8c12edff939a720afdf481143535932b48f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Aflatoxin B 1</topic><topic>aflatoxin B1</topic><topic>Aflatoxin B1 - toxicity</topic><topic>Algae</topic><topic>Animal Feed - adverse effects</topic><topic>Animal Feed - microbiology</topic><topic>Animal Husbandry - methods</topic><topic>Animals</topic><topic>Bacteria</topic><topic>Carcinogens</topic><topic>Chicken</topic><topic>chickens</topic><topic>Chickens - physiology</topic><topic>Comet Assay - veterinary</topic><topic>Contamination</topic><topic>Deoxyribonucleic acid</topic><topic>Dietary Supplements</topic><topic>DNA</topic><topic>DNA damage</topic><topic>DNA Damage - drug effects</topic><topic>DNA Damage - genetics</topic><topic>Economic justification</topic><topic>feces</topic><topic>Feces - microbiology</topic><topic>feed contamination</topic><topic>Feeds</topic><topic>Female</topic><topic>Fodder</topic><topic>Food contamination & poisoning</topic><topic>genotoxicity</topic><topic>human cell lines</topic><topic>Humans</topic><topic>Lymphocytes</topic><topic>Lymphocytes - drug effects</topic><topic>Metabolites</topic><topic>Microbiology</topic><topic>Microorganisms</topic><topic>Mutagenicity Tests - veterinary</topic><topic>Poultry Diseases - prevention & control</topic><topic>poultry feeding</topic><topic>Probiotics</topic><topic>Probiotics - therapeutic use</topic><topic>Raw materials</topic><topic>Toxins</topic><topic>Veterinary medicine</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Slizewska, Katarzyna</creatorcontrib><creatorcontrib>Nowak, Adriana</creatorcontrib><creatorcontrib>Libudzisz, Zdzislawa</creatorcontrib><creatorcontrib>Blasiak, Janusz</creatorcontrib><collection>AGRIS</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Animal Behavior Abstracts</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Immunology Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Neurosciences Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><jtitle>Research in veterinary science</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Slizewska, Katarzyna</au><au>Nowak, Adriana</au><au>Libudzisz, Zdzislawa</au><au>Blasiak, Janusz</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Probiotic preparation reduces the faecal water genotoxicity in chickens fed with aflatoxin B1 contaminated fodder</atitle><jtitle>Research in veterinary science</jtitle><addtitle>Res Vet Sci</addtitle><date>2010-12-01</date><risdate>2010</risdate><volume>89</volume><issue>3</issue><spage>391</spage><epage>395</epage><pages>391-395</pages><issn>0034-5288</issn><eissn>1532-2661</eissn><abstract>The aim of the study was to evaluate the influence of a probiotic preparation on the genotoxicity of faecal water of broiler chickens fed with a fodder contaminated with aflatoxin B
1 (AFB
1) at 1 or 5
mg per kg. Human blood lymphocytes were exposed to chicken’s faecal water samples and DNA damage was measured using the comet assay. Genotoxicity of faecal water did not depend on the AFB
1 concentration in the fodder. The mean DNA damage, measured as the percentage of DNA in the tail of the comets, for chickens fed with fodder with AFB
1 at 1
mg/kg was 16.80
±
0.66, at 5
mg/kg – 16.73
±
1.51 and in the controls – 12.79
±
0.66. The supplementation of fodder with the probiotic preparation decreased the extent of DNA damage to 10.02
±
0.39 for 1
mg/kg AFB
1 and to 11.89
±
0.72 for 5
mg/kg.</abstract><cop>England</cop><pub>Elsevier India Pvt Ltd</pub><pmid>20435327</pmid><doi>10.1016/j.rvsc.2010.04.004</doi><tpages>5</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0034-5288 |
| ispartof | Research in veterinary science, 2010-12, Vol.89 (3), p.391-395 |
| issn | 0034-5288 1532-2661 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_815543375 |
| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Aflatoxin B 1 aflatoxin B1 Aflatoxin B1 - toxicity Algae Animal Feed - adverse effects Animal Feed - microbiology Animal Husbandry - methods Animals Bacteria Carcinogens Chicken chickens Chickens - physiology Comet Assay - veterinary Contamination Deoxyribonucleic acid Dietary Supplements DNA DNA damage DNA Damage - drug effects DNA Damage - genetics Economic justification feces Feces - microbiology feed contamination Feeds Female Fodder Food contamination & poisoning genotoxicity human cell lines Humans Lymphocytes Lymphocytes - drug effects Metabolites Microbiology Microorganisms Mutagenicity Tests - veterinary Poultry Diseases - prevention & control poultry feeding Probiotics Probiotics - therapeutic use Raw materials Toxins Veterinary medicine |
| title | Probiotic preparation reduces the faecal water genotoxicity in chickens fed with aflatoxin B1 contaminated fodder |
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