Modulation of annexin I and cyclooxygenase-2 in smokeless tobacco-induced inflammation and oral cancer

Smokeless tobacco usage is a growing public health concern in the United States. Epidemiological evidence shows a correlation between use of chewing tobacco, lesions of the oral cavity and the incidence of oral and other cancers. However, the molecular mechanism(s) underlying the oral cancer causati...

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Veröffentlicht in:	Molecular and cellular biochemistry 2003-06, Vol.248 (1-2), p.67-75
Hauptverfasser:	Vishwanatha, Jamboor K, Swinney, Ryan, Banerjee, Abhijit G
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Annexin A1 - biosynthesis Annexin A1 - metabolism Anti-Inflammatory Agents - pharmacology Apoptosis Blotting, Western Cancer Carcinoma, Squamous Cell - pathology Cell Death Cell Differentiation Cell Line Cell Line, Tumor Cheek - pathology Cricetinae Cyclooxygenase 2 Dinoprostone - metabolism DNA Damage Dose-Response Relationship, Drug Epithelial Cells - metabolism Head & neck cancer Humans Immunohistochemistry Inflammation - metabolism Isoenzymes - biosynthesis Isoenzymes - metabolism Male Membrane Proteins Mesocricetus Mouth Neoplasms - metabolism Oral cancer Polymerase Chain Reaction Prostaglandin-Endoperoxide Synthases - biosynthesis Prostaglandin-Endoperoxide Synthases - metabolism Public health RNA - metabolism Time Factors Tobacco Tobacco, Smokeless Up-Regulation
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