Molecular mechanism of action of major Helicobacter pylori virulence factors
Although Helicobacter pylori infects 50% of the total human population, only a small fraction of the infected people suffer from severe diseases like peptic ulcers and gastric adenocarcinoma. H. pylori strains, host genotypes and environmental factors play important role in deciding the extent and s...
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| Veröffentlicht in: | Molecular and cellular biochemistry 2003-11, Vol.253 (1-2), p.207-215 |
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| container_title | Molecular and cellular biochemistry |
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| creator | Dhar, Suman Kumar Soni, Rajesh K Das, Bimal K Mukhopadhyay, Gauranga |
| description | Although Helicobacter pylori infects 50% of the total human population, only a small fraction of the infected people suffer from severe diseases like peptic ulcers and gastric adenocarcinoma. H. pylori strains, host genotypes and environmental factors play important role in deciding the extent and severity of the gastroduodenal diseases. The bacteria has developed a unique set of virulence factors to survive in the extreme ecological niche of human stomach. Together these virulence factors make H. pylori one of the most successful human pathogenic bacteria colonizing more than half of the human population. Understanding the mechanism of action of the major H. pylori virulence factors will shed light into the molecular basis of its pathogenicity. |
| doi_str_mv | 10.1023/A:1026051530512 |
| format | Article |
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H. pylori strains, host genotypes and environmental factors play important role in deciding the extent and severity of the gastroduodenal diseases. The bacteria has developed a unique set of virulence factors to survive in the extreme ecological niche of human stomach. Together these virulence factors make H. pylori one of the most successful human pathogenic bacteria colonizing more than half of the human population. Understanding the mechanism of action of the major H. pylori virulence factors will shed light into the molecular basis of its pathogenicity.</description><identifier>ISSN: 0300-8177</identifier><identifier>EISSN: 1573-4919</identifier><identifier>DOI: 10.1023/A:1026051530512</identifier><identifier>PMID: 14619971</identifier><language>eng</language><publisher>Netherlands: Springer Nature B.V</publisher><subject>Adhesins, Bacterial - metabolism ; Bacteria ; Bacterial Adhesion - physiology ; Bacterial Proteins - metabolism ; Environmental factors ; Flagella - metabolism ; Genotypes ; Helicobacter Infections - drug therapy ; Helicobacter Infections - metabolism ; Helicobacter pylori ; Helicobacter pylori - metabolism ; Helicobacter pylori - pathogenicity ; Human populations ; Humans ; Microbiology ; Pathogens ; Peptic Ulcer - drug therapy ; Peptic Ulcer - metabolism ; Stomach Neoplasms - drug therapy ; Stomach Neoplasms - metabolism ; Urease - metabolism ; Virulence</subject><ispartof>Molecular and cellular biochemistry, 2003-11, Vol.253 (1-2), p.207-215</ispartof><rights>Kluwer Academic Publishers 2003</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c353t-5d462117f11eba0a850aa71879c2b63bacb2ff3717785b32c8ca5ef7c924aa553</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/14619971$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Dhar, Suman Kumar</creatorcontrib><creatorcontrib>Soni, Rajesh K</creatorcontrib><creatorcontrib>Das, Bimal K</creatorcontrib><creatorcontrib>Mukhopadhyay, Gauranga</creatorcontrib><title>Molecular mechanism of action of major Helicobacter pylori virulence factors</title><title>Molecular and cellular biochemistry</title><addtitle>Mol Cell Biochem</addtitle><description>Although Helicobacter pylori infects 50% of the total human population, only a small fraction of the infected people suffer from severe diseases like peptic ulcers and gastric adenocarcinoma. H. pylori strains, host genotypes and environmental factors play important role in deciding the extent and severity of the gastroduodenal diseases. The bacteria has developed a unique set of virulence factors to survive in the extreme ecological niche of human stomach. Together these virulence factors make H. pylori one of the most successful human pathogenic bacteria colonizing more than half of the human population. 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| subjects | Adhesins, Bacterial - metabolism Bacteria Bacterial Adhesion - physiology Bacterial Proteins - metabolism Environmental factors Flagella - metabolism Genotypes Helicobacter Infections - drug therapy Helicobacter Infections - metabolism Helicobacter pylori Helicobacter pylori - metabolism Helicobacter pylori - pathogenicity Human populations Humans Microbiology Pathogens Peptic Ulcer - drug therapy Peptic Ulcer - metabolism Stomach Neoplasms - drug therapy Stomach Neoplasms - metabolism Urease - metabolism Virulence |
| title | Molecular mechanism of action of major Helicobacter pylori virulence factors |
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