New polyazole derivatives from 2-(2,4-dichlorophyenyl)-1,3-dioxolane. Antifungal activity. Structure-activity relationships
Six new polyazole derivatives from 2-(2,4-dichlorophenyl)-1,3-dioxolane were studied for their antifungal activity against pathogenic fungi for humans and animals. The antimycotic effect was largely restricted to the filamentous fungi with Aspergillus fumigatus and Scedosporium apiospermum being rem...
Gespeichert in:
| Veröffentlicht in: | Mycopathologia (1975) 1997-01, Vol.137 (1), p.27-32 |
|---|---|
| Hauptverfasser: | , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 32 |
|---|---|
| container_issue | 1 |
| container_start_page | 27 |
| container_title | Mycopathologia (1975) |
| container_volume | 137 |
| creator | Delcourt, A Mathieu, G Baji, H Kimny, T Flammang, M Compagnon, P.L |
| description | Six new polyazole derivatives from 2-(2,4-dichlorophenyl)-1,3-dioxolane were studied for their antifungal activity against pathogenic fungi for humans and animals. The antimycotic effect was largely restricted to the filamentous fungi with Aspergillus fumigatus and Scedosporium apiospermum being remarkably susceptible. Three compounds were as effective as the two references, ketoconazole and oxiconazole. The structure-activity relationships revealed than an 'oxime group' combined with four chlorine atoms increased the antifungal properties of the chemical series. |
| doi_str_mv | 10.1023/A:1006837606890 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_proquest_miscellaneous_815541811</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>815541811</sourcerecordid><originalsourceid>FETCH-LOGICAL-c395t-8d2814111a9666f21aea72f531b992fd6b6bec0ffec2823c0cdd74c15bea76ee3</originalsourceid><addsrcrecordid>eNp90Mtv1DAQB2ALgcpSOHNCRAjxkOrFY8ev3lYVL6mCQ6nELXIcu5vKGwc7aQn887h04cCBiy3NfP6NbYQeA1kDoezN5hgIEYpJUVZN7qAVcMkwUYzeRSvCCOBaia_30YOcLwkpGOQBOtBUa8n5Cv385K6rMYbF_IjBVZ1L_ZWZ-iuXK5_irqL4FT2qcdfbbYgpjtvFDUt4jeGIlWL8HoMZ3LraDFPv5-HChMrYcryflnV1NqXZTnNy-E-tSi6U9DjkbT_mh-ieNyG7R_v9EJ2_e_vl5AM-_fz-48nmFFum-YRVRxXUAGC0EMJTMM5I6jmDVmvqO9GK1lnivbNUUWaJ7TpZW-BtccI5dohe3uaOKX6bXZ6aXZ-tCzdXj3NuFHBegwIo8sV_JUjgVPMb-OwfeBnnNJRXNJSWIEKVKOjJHs3tznXNmPqdSUuz__zSf77vm2xN8MkMts9_GVWklkwX9vSWeRMbc5EKOT-j5PcQKRTR7BfsCpzr</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>221130286</pqid></control><display><type>article</type><title>New polyazole derivatives from 2-(2,4-dichlorophyenyl)-1,3-dioxolane. Antifungal activity. Structure-activity relationships</title><source>MEDLINE</source><source>SpringerLink Journals - AutoHoldings</source><creator>Delcourt, A ; Mathieu, G ; Baji, H ; Kimny, T ; Flammang, M ; Compagnon, P.L</creator><creatorcontrib>Delcourt, A ; Mathieu, G ; Baji, H ; Kimny, T ; Flammang, M ; Compagnon, P.L</creatorcontrib><description>Six new polyazole derivatives from 2-(2,4-dichlorophenyl)-1,3-dioxolane were studied for their antifungal activity against pathogenic fungi for humans and animals. The antimycotic effect was largely restricted to the filamentous fungi with Aspergillus fumigatus and Scedosporium apiospermum being remarkably susceptible. Three compounds were as effective as the two references, ketoconazole and oxiconazole. The structure-activity relationships revealed than an 'oxime group' combined with four chlorine atoms increased the antifungal properties of the chemical series.</description><identifier>ISSN: 0301-486X</identifier><identifier>EISSN: 1573-0832</identifier><identifier>DOI: 10.1023/A:1006837606890</identifier><identifier>PMID: 9299755</identifier><identifier>CODEN: MYCPAH</identifier><language>eng</language><publisher>Dordrecht: Springer</publisher><subject>Absidia ; Alternaria ; Antibiotics. Antiinfectious agents. Antiparasitic agents ; Antifungal agents ; Antifungal Agents - pharmacology ; antifungal properties ; Arthrodermataceae - drug effects ; Aspergillus fumigatus ; azoles ; Azoles - pharmacology ; Biological and medical sciences ; biological resistance ; Biosynthesis ; Candida ; Candida - drug effects ; chemical structure ; Chlorine ; Cladosporium ; cryptococcus (deuteromycotina) ; derivatives ; diameter ; Dioxolanes - chemistry ; Dose-Response Relationship, Drug ; Fungi ; Fusarium ; growth ; Imidazoles - pharmacology ; Ketoconazole - pharmacology ; Madurella ; Medical sciences ; Microbial Sensitivity Tests - standards ; Microsporum ; Mitosporic Fungi - drug effects ; oximes ; Pharmacology. Drug treatments ; Scedosporium apiospermum ; Scopulariopsis ; Species Specificity ; Sterols ; Structure-Activity Relationship ; structure-activity relationships ; Trichophyton</subject><ispartof>Mycopathologia (1975), 1997-01, Vol.137 (1), p.27-32</ispartof><rights>1997 INIST-CNRS</rights><rights>Kluwer Academic Publishers 1997</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c395t-8d2814111a9666f21aea72f531b992fd6b6bec0ffec2823c0cdd74c15bea76ee3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27923,27924</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2804739$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9299755$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Delcourt, A</creatorcontrib><creatorcontrib>Mathieu, G</creatorcontrib><creatorcontrib>Baji, H</creatorcontrib><creatorcontrib>Kimny, T</creatorcontrib><creatorcontrib>Flammang, M</creatorcontrib><creatorcontrib>Compagnon, P.L</creatorcontrib><title>New polyazole derivatives from 2-(2,4-dichlorophyenyl)-1,3-dioxolane. Antifungal activity. Structure-activity relationships</title><title>Mycopathologia (1975)</title><addtitle>Mycopathologia</addtitle><description>Six new polyazole derivatives from 2-(2,4-dichlorophenyl)-1,3-dioxolane were studied for their antifungal activity against pathogenic fungi for humans and animals. The antimycotic effect was largely restricted to the filamentous fungi with Aspergillus fumigatus and Scedosporium apiospermum being remarkably susceptible. Three compounds were as effective as the two references, ketoconazole and oxiconazole. The structure-activity relationships revealed than an 'oxime group' combined with four chlorine atoms increased the antifungal properties of the chemical series.</description><subject>Absidia</subject><subject>Alternaria</subject><subject>Antibiotics. Antiinfectious agents. Antiparasitic agents</subject><subject>Antifungal agents</subject><subject>Antifungal Agents - pharmacology</subject><subject>antifungal properties</subject><subject>Arthrodermataceae - drug effects</subject><subject>Aspergillus fumigatus</subject><subject>azoles</subject><subject>Azoles - pharmacology</subject><subject>Biological and medical sciences</subject><subject>biological resistance</subject><subject>Biosynthesis</subject><subject>Candida</subject><subject>Candida - drug effects</subject><subject>chemical structure</subject><subject>Chlorine</subject><subject>Cladosporium</subject><subject>cryptococcus (deuteromycotina)</subject><subject>derivatives</subject><subject>diameter</subject><subject>Dioxolanes - chemistry</subject><subject>Dose-Response Relationship, Drug</subject><subject>Fungi</subject><subject>Fusarium</subject><subject>growth</subject><subject>Imidazoles - pharmacology</subject><subject>Ketoconazole - pharmacology</subject><subject>Madurella</subject><subject>Medical sciences</subject><subject>Microbial Sensitivity Tests - standards</subject><subject>Microsporum</subject><subject>Mitosporic Fungi - drug effects</subject><subject>oximes</subject><subject>Pharmacology. Drug treatments</subject><subject>Scedosporium apiospermum</subject><subject>Scopulariopsis</subject><subject>Species Specificity</subject><subject>Sterols</subject><subject>Structure-Activity Relationship</subject><subject>structure-activity relationships</subject><subject>Trichophyton</subject><issn>0301-486X</issn><issn>1573-0832</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1997</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp90Mtv1DAQB2ALgcpSOHNCRAjxkOrFY8ev3lYVL6mCQ6nELXIcu5vKGwc7aQn887h04cCBiy3NfP6NbYQeA1kDoezN5hgIEYpJUVZN7qAVcMkwUYzeRSvCCOBaia_30YOcLwkpGOQBOtBUa8n5Cv385K6rMYbF_IjBVZ1L_ZWZ-iuXK5_irqL4FT2qcdfbbYgpjtvFDUt4jeGIlWL8HoMZ3LraDFPv5-HChMrYcryflnV1NqXZTnNy-E-tSi6U9DjkbT_mh-ieNyG7R_v9EJ2_e_vl5AM-_fz-48nmFFum-YRVRxXUAGC0EMJTMM5I6jmDVmvqO9GK1lnivbNUUWaJ7TpZW-BtccI5dohe3uaOKX6bXZ6aXZ-tCzdXj3NuFHBegwIo8sV_JUjgVPMb-OwfeBnnNJRXNJSWIEKVKOjJHs3tznXNmPqdSUuz__zSf77vm2xN8MkMts9_GVWklkwX9vSWeRMbc5EKOT-j5PcQKRTR7BfsCpzr</recordid><startdate>19970101</startdate><enddate>19970101</enddate><creator>Delcourt, A</creator><creator>Mathieu, G</creator><creator>Baji, H</creator><creator>Kimny, T</creator><creator>Flammang, M</creator><creator>Compagnon, P.L</creator><general>Springer</general><general>Springer Nature B.V</general><scope>FBQ</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>8AO</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7QO</scope><scope>7T7</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>P64</scope></search><sort><creationdate>19970101</creationdate><title>New polyazole derivatives from 2-(2,4-dichlorophyenyl)-1,3-dioxolane. Antifungal activity. Structure-activity relationships</title><author>Delcourt, A ; Mathieu, G ; Baji, H ; Kimny, T ; Flammang, M ; Compagnon, P.L</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c395t-8d2814111a9666f21aea72f531b992fd6b6bec0ffec2823c0cdd74c15bea76ee3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1997</creationdate><topic>Absidia</topic><topic>Alternaria</topic><topic>Antibiotics. Antiinfectious agents. Antiparasitic agents</topic><topic>Antifungal agents</topic><topic>Antifungal Agents - pharmacology</topic><topic>antifungal properties</topic><topic>Arthrodermataceae - drug effects</topic><topic>Aspergillus fumigatus</topic><topic>azoles</topic><topic>Azoles - pharmacology</topic><topic>Biological and medical sciences</topic><topic>biological resistance</topic><topic>Biosynthesis</topic><topic>Candida</topic><topic>Candida - drug effects</topic><topic>chemical structure</topic><topic>Chlorine</topic><topic>Cladosporium</topic><topic>cryptococcus (deuteromycotina)</topic><topic>derivatives</topic><topic>diameter</topic><topic>Dioxolanes - chemistry</topic><topic>Dose-Response Relationship, Drug</topic><topic>Fungi</topic><topic>Fusarium</topic><topic>growth</topic><topic>Imidazoles - pharmacology</topic><topic>Ketoconazole - pharmacology</topic><topic>Madurella</topic><topic>Medical sciences</topic><topic>Microbial Sensitivity Tests - standards</topic><topic>Microsporum</topic><topic>Mitosporic Fungi - drug effects</topic><topic>oximes</topic><topic>Pharmacology. Drug treatments</topic><topic>Scedosporium apiospermum</topic><topic>Scopulariopsis</topic><topic>Species Specificity</topic><topic>Sterols</topic><topic>Structure-Activity Relationship</topic><topic>structure-activity relationships</topic><topic>Trichophyton</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Delcourt, A</creatorcontrib><creatorcontrib>Mathieu, G</creatorcontrib><creatorcontrib>Baji, H</creatorcontrib><creatorcontrib>Kimny, T</creatorcontrib><creatorcontrib>Flammang, M</creatorcontrib><creatorcontrib>Compagnon, P.L</creatorcontrib><collection>AGRIS</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biological Science Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>Biotechnology Research Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><jtitle>Mycopathologia (1975)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Delcourt, A</au><au>Mathieu, G</au><au>Baji, H</au><au>Kimny, T</au><au>Flammang, M</au><au>Compagnon, P.L</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>New polyazole derivatives from 2-(2,4-dichlorophyenyl)-1,3-dioxolane. Antifungal activity. Structure-activity relationships</atitle><jtitle>Mycopathologia (1975)</jtitle><addtitle>Mycopathologia</addtitle><date>1997-01-01</date><risdate>1997</risdate><volume>137</volume><issue>1</issue><spage>27</spage><epage>32</epage><pages>27-32</pages><issn>0301-486X</issn><eissn>1573-0832</eissn><coden>MYCPAH</coden><abstract>Six new polyazole derivatives from 2-(2,4-dichlorophenyl)-1,3-dioxolane were studied for their antifungal activity against pathogenic fungi for humans and animals. The antimycotic effect was largely restricted to the filamentous fungi with Aspergillus fumigatus and Scedosporium apiospermum being remarkably susceptible. Three compounds were as effective as the two references, ketoconazole and oxiconazole. The structure-activity relationships revealed than an 'oxime group' combined with four chlorine atoms increased the antifungal properties of the chemical series.</abstract><cop>Dordrecht</cop><pub>Springer</pub><pmid>9299755</pmid><doi>10.1023/A:1006837606890</doi><tpages>6</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0301-486X |
| ispartof | Mycopathologia (1975), 1997-01, Vol.137 (1), p.27-32 |
| issn | 0301-486X 1573-0832 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_815541811 |
| source | MEDLINE; SpringerLink Journals - AutoHoldings |
| subjects | Absidia Alternaria Antibiotics. Antiinfectious agents. Antiparasitic agents Antifungal agents Antifungal Agents - pharmacology antifungal properties Arthrodermataceae - drug effects Aspergillus fumigatus azoles Azoles - pharmacology Biological and medical sciences biological resistance Biosynthesis Candida Candida - drug effects chemical structure Chlorine Cladosporium cryptococcus (deuteromycotina) derivatives diameter Dioxolanes - chemistry Dose-Response Relationship, Drug Fungi Fusarium growth Imidazoles - pharmacology Ketoconazole - pharmacology Madurella Medical sciences Microbial Sensitivity Tests - standards Microsporum Mitosporic Fungi - drug effects oximes Pharmacology. Drug treatments Scedosporium apiospermum Scopulariopsis Species Specificity Sterols Structure-Activity Relationship structure-activity relationships Trichophyton |
| title | New polyazole derivatives from 2-(2,4-dichlorophyenyl)-1,3-dioxolane. Antifungal activity. Structure-activity relationships |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-12T02%3A26%3A49IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=New%20polyazole%20derivatives%20from%202-(2,4-dichlorophyenyl)-1,3-dioxolane.%20Antifungal%20activity.%20Structure-activity%20relationships&rft.jtitle=Mycopathologia%20(1975)&rft.au=Delcourt,%20A&rft.date=1997-01-01&rft.volume=137&rft.issue=1&rft.spage=27&rft.epage=32&rft.pages=27-32&rft.issn=0301-486X&rft.eissn=1573-0832&rft.coden=MYCPAH&rft_id=info:doi/10.1023/A:1006837606890&rft_dat=%3Cproquest_pubme%3E815541811%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=221130286&rft_id=info:pmid/9299755&rfr_iscdi=true |