Darunavir concentrations exceed the protein-corrected EC sub(50) for wild-type HIV in the semen of HIV-1-infected men
Variable antiretroviral drug penetration into the genital tract may contribute to the differential evolution of HIV-1 and the emergence of drug resistance. We compared concentrations of darunavir in 34 time-matched blood plasma and seminal plasma samples from 18 HIV-1 positive men. Darunavir in semi...
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| Veröffentlicht in: | AIDS (London) 2010-10, Vol.24 (16), p.2583-2583 |
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| container_end_page | 2583 |
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| container_issue | 16 |
| container_start_page | 2583 |
| container_title | AIDS (London) |
| container_volume | 24 |
| creator | Taylor, S Jayasuriya, AN Berry, A Gilleran, G Dufty, N E Else, L Back, D J Smit, E J |
| description | Variable antiretroviral drug penetration into the genital tract may contribute to the differential evolution of HIV-1 and the emergence of drug resistance. We compared concentrations of darunavir in 34 time-matched blood plasma and seminal plasma samples from 18 HIV-1 positive men. Darunavir in seminal plasma were approximately 10-20% of that achieved in blood at matched time points postdrug ingestion. All seminal plasma darunavir were above the protein-corrected EC sub(50) values for wild-type HIV-1. |
| doi_str_mv | 10.1097/QAD.0b013e32833ead18 |
| format | Article |
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| fulltext | fulltext |
| identifier | ISSN: 0269-9370 |
| ispartof | AIDS (London), 2010-10, Vol.24 (16), p.2583-2583 |
| issn | 0269-9370 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_815541655 |
| source | Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Journals@Ovid Complete |
| subjects | Human immunodeficiency virus 1 |
| title | Darunavir concentrations exceed the protein-corrected EC sub(50) for wild-type HIV in the semen of HIV-1-infected men |
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