Zinc inhibits nonheme iron bioavailability in humans
There is increasing concern about potential negative interactions in combined iron and zinc supplementation. The aim of the present study was to determine the dose-response effect of zinc, given as a solution, on iron bioavailability. Twenty-two healthy adult women were selected to participate in th...
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| Veröffentlicht in: | Biological trace element research 2007-06, Vol.117 (1-3), p.7-14 |
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| creator | Olivares, M Pizarro, F Ruz, M |
| description | There is increasing concern about potential negative interactions in combined iron and zinc supplementation. The aim of the present study was to determine the dose-response effect of zinc, given as a solution, on iron bioavailability. Twenty-two healthy adult women were selected to participate in the study. Iron, with or without zinc was given as an aqueous solution on d 1,2,14, and 15 of the study. Iron bioavailability was measured on the basis of erythrocyte incorporation of 55Fe or 59Fe 14 d after administration. Subjects received 0.5 mg of iron together with graded zinc concentrations (0-11.71 mg). No significant effect of zinc on iron absorption was found at Zn:Fe molar ratios up to 2:1. At 5:1,10:1, and 20:1 molar ratios, a dose-dependent inhibitory effect on iron absorption was observed (28-40% of iron absorption inhibition; one-way repeated-measures ANOVA, F=4.48, p=0.02). In conclusion, zinc administration combined with iron in an aqueous solution leads to the inhibition of iron bioavailability, which occurs in a dose-dependent way. This negative interaction should be considered for supplementation programs with both microminerals. |
| doi_str_mv | 10.1007/BF02698079 |
| format | Article |
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The aim of the present study was to determine the dose-response effect of zinc, given as a solution, on iron bioavailability. Twenty-two healthy adult women were selected to participate in the study. Iron, with or without zinc was given as an aqueous solution on d 1,2,14, and 15 of the study. Iron bioavailability was measured on the basis of erythrocyte incorporation of 55Fe or 59Fe 14 d after administration. Subjects received 0.5 mg of iron together with graded zinc concentrations (0-11.71 mg). No significant effect of zinc on iron absorption was found at Zn:Fe molar ratios up to 2:1. At 5:1,10:1, and 20:1 molar ratios, a dose-dependent inhibitory effect on iron absorption was observed (28-40% of iron absorption inhibition; one-way repeated-measures ANOVA, F=4.48, p=0.02). In conclusion, zinc administration combined with iron in an aqueous solution leads to the inhibition of iron bioavailability, which occurs in a dose-dependent way. This negative interaction should be considered for supplementation programs with both microminerals.</description><identifier>ISSN: 0163-4984</identifier><identifier>EISSN: 1559-0720</identifier><identifier>DOI: 10.1007/BF02698079</identifier><identifier>PMID: 17873388</identifier><language>eng</language><publisher>United States: Springer Nature B.V</publisher><subject>Absorption ; Adult ; Bioavailability ; Biological Availability ; Dose-response effects ; Dose-Response Relationship, Drug ; Female ; Humans ; Iron ; Iron - administration & dosage ; Iron - antagonists & inhibitors ; Iron - metabolism ; Iron Radioisotopes - metabolism ; Middle Aged ; Nutrition ; Solutions ; Variance analysis ; Zinc ; Zinc - administration & dosage ; Zinc - physiology</subject><ispartof>Biological trace element research, 2007-06, Vol.117 (1-3), p.7-14</ispartof><rights>Humana Press 2007</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c344t-d78925888db655fd749e456dc4f817d1f76b8be8d6266119feddc54b174a3f9a3</citedby><cites>FETCH-LOGICAL-c344t-d78925888db655fd749e456dc4f817d1f76b8be8d6266119feddc54b174a3f9a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,778,782,27907,27908</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17873388$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Olivares, M</creatorcontrib><creatorcontrib>Pizarro, F</creatorcontrib><creatorcontrib>Ruz, M</creatorcontrib><title>Zinc inhibits nonheme iron bioavailability in humans</title><title>Biological trace element research</title><addtitle>Biol Trace Elem Res</addtitle><description>There is increasing concern about potential negative interactions in combined iron and zinc supplementation. The aim of the present study was to determine the dose-response effect of zinc, given as a solution, on iron bioavailability. Twenty-two healthy adult women were selected to participate in the study. Iron, with or without zinc was given as an aqueous solution on d 1,2,14, and 15 of the study. Iron bioavailability was measured on the basis of erythrocyte incorporation of 55Fe or 59Fe 14 d after administration. Subjects received 0.5 mg of iron together with graded zinc concentrations (0-11.71 mg). No significant effect of zinc on iron absorption was found at Zn:Fe molar ratios up to 2:1. At 5:1,10:1, and 20:1 molar ratios, a dose-dependent inhibitory effect on iron absorption was observed (28-40% of iron absorption inhibition; one-way repeated-measures ANOVA, F=4.48, p=0.02). In conclusion, zinc administration combined with iron in an aqueous solution leads to the inhibition of iron bioavailability, which occurs in a dose-dependent way. This negative interaction should be considered for supplementation programs with both microminerals.</description><subject>Absorption</subject><subject>Adult</subject><subject>Bioavailability</subject><subject>Biological Availability</subject><subject>Dose-response effects</subject><subject>Dose-Response Relationship, Drug</subject><subject>Female</subject><subject>Humans</subject><subject>Iron</subject><subject>Iron - administration & dosage</subject><subject>Iron - antagonists & inhibitors</subject><subject>Iron - metabolism</subject><subject>Iron Radioisotopes - metabolism</subject><subject>Middle Aged</subject><subject>Nutrition</subject><subject>Solutions</subject><subject>Variance analysis</subject><subject>Zinc</subject><subject>Zinc - administration & dosage</subject><subject>Zinc - physiology</subject><issn>0163-4984</issn><issn>1559-0720</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp90M9LwzAcBfAgipvVi3-AFA8KQjW_mnxz1OFUGHjRi5eSNCnLaNPZtML-ezs2GHjw9C4fHryH0CXB9wRj-fA0x1QowFIdoSnJc5VhSfExmmIiWMYV8Ak6i3GFMZFUsVM0IRIkYwBTxL98KFMflt74PqahDUvXuNR3bUiNb_WP9rU2vvb9ZlTpcmh0iOfopNJ1dBf7TNDn_Plj9pot3l_eZo-LrGSc95mVoGgOANaIPK-s5MrxXNiSV0CkJZUUBowDK6gQhKjKWVvm3BDJNauUZgm63fWuu_Z7cLEvGh9LV9c6uHaIBYxjmQKGR3nzrxRAJeUSRnj9B67aoQvjioISYEJt-xJ0t0Nl18bYuapYd77R3aYguNheXhwuH_HVvnEwjbMHuv-Y_QLAMnmV</recordid><startdate>20070601</startdate><enddate>20070601</enddate><creator>Olivares, M</creator><creator>Pizarro, F</creator><creator>Ruz, M</creator><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QH</scope><scope>7QP</scope><scope>7TN</scope><scope>7U7</scope><scope>7UA</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>88I</scope><scope>8AO</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>BKSAR</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>F1W</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H97</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>L.G</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>M7P</scope><scope>PCBAR</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>7X8</scope></search><sort><creationdate>20070601</creationdate><title>Zinc inhibits nonheme iron bioavailability in humans</title><author>Olivares, M ; 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The aim of the present study was to determine the dose-response effect of zinc, given as a solution, on iron bioavailability. Twenty-two healthy adult women were selected to participate in the study. Iron, with or without zinc was given as an aqueous solution on d 1,2,14, and 15 of the study. Iron bioavailability was measured on the basis of erythrocyte incorporation of 55Fe or 59Fe 14 d after administration. Subjects received 0.5 mg of iron together with graded zinc concentrations (0-11.71 mg). No significant effect of zinc on iron absorption was found at Zn:Fe molar ratios up to 2:1. At 5:1,10:1, and 20:1 molar ratios, a dose-dependent inhibitory effect on iron absorption was observed (28-40% of iron absorption inhibition; one-way repeated-measures ANOVA, F=4.48, p=0.02). In conclusion, zinc administration combined with iron in an aqueous solution leads to the inhibition of iron bioavailability, which occurs in a dose-dependent way. This negative interaction should be considered for supplementation programs with both microminerals.</abstract><cop>United States</cop><pub>Springer Nature B.V</pub><pmid>17873388</pmid><doi>10.1007/BF02698079</doi><tpages>8</tpages></addata></record> |
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| subjects | Absorption Adult Bioavailability Biological Availability Dose-response effects Dose-Response Relationship, Drug Female Humans Iron Iron - administration & dosage Iron - antagonists & inhibitors Iron - metabolism Iron Radioisotopes - metabolism Middle Aged Nutrition Solutions Variance analysis Zinc Zinc - administration & dosage Zinc - physiology |
| title | Zinc inhibits nonheme iron bioavailability in humans |
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