Primary Screening Approach for Anti-Inflammatory Agents Utilizing an In Vivo and a New In Vitro Method

Several classes of standard pharmacological agents (approximately 38 different drugs) including anti-inflammatory, antiarthritic, analgesic, immunosuppressive, antihistaminic, autonomic, and CNS agents were tested in the in vivo carrageenin-inflamed rat paw test (Test 1) and in an in vitro test invo...

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Veröffentlicht in:	Journal of pharmaceutical sciences 1972-09, Vol.61 (9), p.1450-1454
Hauptverfasser:	Carrano, R.A., Malbica, J.O.
Format:	Artikel
Sprache:	eng
Schlagworte:	Analgesics - pharmacology Animals Anti-inflammatory agents Anti-Inflammatory Agents - pharmacology Anti-inflammatory agents, screening program—correlation between in vivo carrageenin-induced edema and in vitro lysosomal-labilizing properties of N,N,N′,N′-tetramethylazoformamide, rats anti-inflammatory agents-correlation between in vivo carrageenin-induced edema and in vitro lysosomal-labilizing properties of N Autonomic Agents - pharmacology Azo Compounds Carrageenan - pharmacology Cell-Free System Chlorpromazine - pharmacology Edema - chemically induced False Positive Reactions Formamides Glucuronidase Imipramine - pharmacology Immunosuppressive Agents - pharmacology Liver - cytology Liver - drug effects Lysosomes - drug effects Lysosomes - enzymology Male Mitochondria, Liver - drug effects N,N,N′,N′-Tetramethylazoformamide lysosomallabilizing properties—effect of anti-inflammatory agents, screening program, rats N′-tetramethylazoformamide N′-Tetramethylazoformamide lysosomallabilizing properties-effect of anti-inflammatory agents Phenobarbital - pharmacology Phosphoric Monoester Hydrolases Rats screening program screening program-correlation between in vivo carrageenin-induced edema and in vitro lysosomal-labilizing properties of N Screening programs Screening programs, anti-inflammatory agents—correlation between in vivo carrageenin-induced edema and in vitro lysosomal-labilizing properties of N,N,N′,N′-tetramethylazoformamide, rats Sulfatases Trimeprazine - pharmacology
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