effects of dietary boric acid on bone strength in rats
The effects of dietary boron (B) (from boric acid [BA]) on bone strength were evaluated using male F344 rats. B was administered by dietary admixture of BA to NIH-07 feed at concentrations of 200, 1000, 3000, and 9000 ppm. The latter two levels were found in previous studies to be reproductively tox...
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| Veröffentlicht in: | Biological trace element research 1998-12, Vol.66 (1/3), p.395-399 |
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| creator | Chapin, R.E Ku, W.W Kenney, M.A McCoy, H |
| description | The effects of dietary boron (B) (from boric acid [BA]) on bone strength were evaluated using male F344 rats. B was administered by dietary admixture of BA to NIH-07 feed at concentrations of 200, 1000, 3000, and 9000 ppm. The latter two levels were found in previous studies to be reproductively toxic to both males and the developing fetus. The first two levels are below and just at, respectively, the levels for producing fetal malformations, and are below the dose required to produce male reproductive toxicity. Resistance to destructive testing was measured on femora, tibiae, and lumbar vertebrae. Although femur and tibia resistance to bending force were not affected by any amount of dietary B, vertebral resistance to a crushing force was increased by approximately 10%, at all dose levels (200-9000 ppm). These data show that even levels of BA that are not reproductively toxic can affect the strength of the axial skeleton in rats. |
| doi_str_mv | 10.1007/bf02783150 |
| format | Article |
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B was administered by dietary admixture of BA to NIH-07 feed at concentrations of 200, 1000, 3000, and 9000 ppm. The latter two levels were found in previous studies to be reproductively toxic to both males and the developing fetus. The first two levels are below and just at, respectively, the levels for producing fetal malformations, and are below the dose required to produce male reproductive toxicity. Resistance to destructive testing was measured on femora, tibiae, and lumbar vertebrae. Although femur and tibia resistance to bending force were not affected by any amount of dietary B, vertebral resistance to a crushing force was increased by approximately 10%, at all dose levels (200-9000 ppm). These data show that even levels of BA that are not reproductively toxic can affect the strength of the axial skeleton in rats.</description><identifier>ISSN: 0163-4984</identifier><identifier>EISSN: 1559-0720</identifier><identifier>DOI: 10.1007/bf02783150</identifier><identifier>PMID: 10050932</identifier><language>eng</language><publisher>United States: Springer Nature B.V</publisher><subject>Acids ; Animals ; Body Weight - drug effects ; Body Weight - physiology ; Bone Density - drug effects ; bone strength ; Bones ; boric acid ; Boric Acids - administration & dosage ; Boric Acids - metabolism ; Boron ; Calcium - blood ; Diet ; Dose-Response Relationship, Drug ; Female ; Femur - drug effects ; Femur - physiology ; Humerus - drug effects ; Humerus - physiology ; Male ; nutrition physiology ; Rats ; Rats, Inbred F344 ; Rodents ; Tibia - drug effects ; Tibia - physiology</subject><ispartof>Biological trace element research, 1998-12, Vol.66 (1/3), p.395-399</ispartof><rights>Humana Press Inc. 1998</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c432t-6311df43da6000f780e95f953b6dbb770651b56103ffcdb1bb1036afc23c770c3</citedby><cites>FETCH-LOGICAL-c432t-6311df43da6000f780e95f953b6dbb770651b56103ffcdb1bb1036afc23c770c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10050932$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Chapin, R.E</creatorcontrib><creatorcontrib>Ku, W.W</creatorcontrib><creatorcontrib>Kenney, M.A</creatorcontrib><creatorcontrib>McCoy, H</creatorcontrib><title>effects of dietary boric acid on bone strength in rats</title><title>Biological trace element research</title><addtitle>Biol Trace Elem Res</addtitle><description>The effects of dietary boron (B) (from boric acid [BA]) on bone strength were evaluated using male F344 rats. B was administered by dietary admixture of BA to NIH-07 feed at concentrations of 200, 1000, 3000, and 9000 ppm. The latter two levels were found in previous studies to be reproductively toxic to both males and the developing fetus. The first two levels are below and just at, respectively, the levels for producing fetal malformations, and are below the dose required to produce male reproductive toxicity. Resistance to destructive testing was measured on femora, tibiae, and lumbar vertebrae. Although femur and tibia resistance to bending force were not affected by any amount of dietary B, vertebral resistance to a crushing force was increased by approximately 10%, at all dose levels (200-9000 ppm). These data show that even levels of BA that are not reproductively toxic can affect the strength of the axial skeleton in rats.</description><subject>Acids</subject><subject>Animals</subject><subject>Body Weight - drug effects</subject><subject>Body Weight - physiology</subject><subject>Bone Density - drug effects</subject><subject>bone strength</subject><subject>Bones</subject><subject>boric acid</subject><subject>Boric Acids - administration & dosage</subject><subject>Boric Acids - metabolism</subject><subject>Boron</subject><subject>Calcium - blood</subject><subject>Diet</subject><subject>Dose-Response Relationship, Drug</subject><subject>Female</subject><subject>Femur - drug effects</subject><subject>Femur - physiology</subject><subject>Humerus - drug effects</subject><subject>Humerus - physiology</subject><subject>Male</subject><subject>nutrition physiology</subject><subject>Rats</subject><subject>Rats, Inbred F344</subject><subject>Rodents</subject><subject>Tibia - drug effects</subject><subject>Tibia - 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drug effects</topic><topic>Body Weight - physiology</topic><topic>Bone Density - drug effects</topic><topic>bone strength</topic><topic>Bones</topic><topic>boric acid</topic><topic>Boric Acids - administration & dosage</topic><topic>Boric Acids - metabolism</topic><topic>Boron</topic><topic>Calcium - blood</topic><topic>Diet</topic><topic>Dose-Response Relationship, Drug</topic><topic>Female</topic><topic>Femur - drug effects</topic><topic>Femur - physiology</topic><topic>Humerus - drug effects</topic><topic>Humerus - physiology</topic><topic>Male</topic><topic>nutrition physiology</topic><topic>Rats</topic><topic>Rats, Inbred F344</topic><topic>Rodents</topic><topic>Tibia - drug effects</topic><topic>Tibia - physiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Chapin, R.E</creatorcontrib><creatorcontrib>Ku, W.W</creatorcontrib><creatorcontrib>Kenney, M.A</creatorcontrib><creatorcontrib>McCoy, H</creatorcontrib><collection>AGRIS</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Aqualine</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Oceanic Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Water Resources Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>Earth, Atmospheric & Aquatic Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>ASFA: Aquatic Sciences and Fisheries Abstracts</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) 3: Aquatic Pollution & Environmental Quality</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) Professional</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Science Database</collection><collection>Biological Science Database</collection><collection>Earth, Atmospheric & Aquatic Science Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><jtitle>Biological trace element research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Chapin, R.E</au><au>Ku, W.W</au><au>Kenney, M.A</au><au>McCoy, H</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>effects of dietary boric acid on bone strength in rats</atitle><jtitle>Biological trace element research</jtitle><addtitle>Biol Trace Elem Res</addtitle><date>1998-12-01</date><risdate>1998</risdate><volume>66</volume><issue>1/3</issue><spage>395</spage><epage>399</epage><pages>395-399</pages><issn>0163-4984</issn><eissn>1559-0720</eissn><abstract>The effects of dietary boron (B) (from boric acid [BA]) on bone strength were evaluated using male F344 rats. 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| ispartof | Biological trace element research, 1998-12, Vol.66 (1/3), p.395-399 |
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| subjects | Acids Animals Body Weight - drug effects Body Weight - physiology Bone Density - drug effects bone strength Bones boric acid Boric Acids - administration & dosage Boric Acids - metabolism Boron Calcium - blood Diet Dose-Response Relationship, Drug Female Femur - drug effects Femur - physiology Humerus - drug effects Humerus - physiology Male nutrition physiology Rats Rats, Inbred F344 Rodents Tibia - drug effects Tibia - physiology |
| title | effects of dietary boric acid on bone strength in rats |
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