Copper-specific damage in human erythrocytes exposed to oxidative stress

Ascorbate and complexes of Cu(II) and Fe(III) are capable of generating significant levels of oxygen free radicals. Exposure of erythrocytes to such oxidative stress leads to increased levels of methemoglobin and extensive changes in cell morphology. Cu(II) per mole is much more effective than Fe(II...

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Veröffentlicht in:	Biological trace element research 1997-02, Vol.56 (2), p.231-240
Hauptverfasser:	Clopton, D A, Saltman, P
Format:	Artikel
Sprache:	eng
Schlagworte:	Cell morphology Copper Copper - adverse effects Copper - blood Copper - toxicity Cytochrome-B Reductase - blood Cytochrome-B Reductase - drug effects Erythrocytes Erythrocytes - drug effects Erythrocytes - metabolism Free radicals Hemoglobins - chemistry Hemoglobins - drug effects Hemolysis - drug effects Humans Iron Methemoglobin - chemistry Methemoglobin - drug effects Oxidative stress Oxidative Stress - drug effects Oxidative Stress - physiology
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