Liver Cancer Protease Activity Profiles Support Therapeutic Options with Matrix Metalloproteinase-Activatable Oncolytic Measles Virus

Primary and secondary cancers of the liver are a significant health problem with limited treatment options. We sought here to develop an oncolytic measles virus (MV) preferentially activated in liver tumor tissue, thus reducing infection and destruction of healthy tissue. We documented that in prima...

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Veröffentlicht in:	Cancer research (Chicago, Ill.) Ill.), 2010-10, Vol.70 (19), p.7620-7629
Hauptverfasser:	MÜHLEBACH, Michael D, SCHASER, Thomas, ZIMMERMANN, Martina, ARMEANU, Sorin, HANSCHMANN, Kay-Martin O, CATTANEO, Roberto, BITZER, Michael, LAUER, Ulrich M, CICHUTEK, Klaus, BUCHHOLZ, Christian J
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic agents Biological and medical sciences Cell Line, Tumor Cercopithecus aethiops Enzyme Activation Gastroenterology. Liver. Pancreas. Abdomen Humans Liver Neoplasms - enzymology Liver Neoplasms - secondary Liver Neoplasms - therapy Liver Neoplasms - virology Liver. Biliary tract. Portal circulation. Exocrine pancreas Matrix Metalloproteinases - metabolism Measles virus Measles virus - physiology Medical sciences Oncolytic Virotherapy - methods Peptide Hydrolases - metabolism Pharmacology. Drug treatments Transfection Tumors Vero Cells Viral Fusion Proteins - metabolism
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