Sex hormones and autoimmunity
Abstract Autoimmune diseases occur more in women than in men, and this may be attributable to the role of estrogens. Androgens promote autoimmune diseases with a profile of type 1 cytokines, such as rheumatoid arthritis, whereas estrogens promote autoimmune diseases with a type 2 cytokine profile, l...
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| Veröffentlicht in: | Immunology letters 2010-09, Vol.133 (1), p.6-13 |
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| container_title | Immunology letters |
| container_volume | 133 |
| creator | González, Delia Almeida Díaz, Buenaventura Brito Rodríguez Pérez, María del Cristo Hernández, Ana González Chico, B. Nicolás Díaz de León, Antonio Cabrera |
| description | Abstract Autoimmune diseases occur more in women than in men, and this may be attributable to the role of estrogens. Androgens promote autoimmune diseases with a profile of type 1 cytokines, such as rheumatoid arthritis, whereas estrogens promote autoimmune diseases with a type 2 cytokine profile, like systemic lupus erythematosus. Both androgens and estrogens regulate the Th1/Th2 balance. Type 1 autoimmune diseases are improved when decrease type 1 cytokines (i.e. during fasting), or when there is a rise in type 2 cytokines (increased estrogens, as in pregnancy). Type 2 autoimmune diseases improve when type 2 cytokines are diminished (decreased estrogen, as in post-partum period) or when type 1 response is stimulated. |
| doi_str_mv | 10.1016/j.imlet.2010.07.001 |
| format | Article |
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All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c445t-824694144ecb8dbba435f77365f1e5121d30c13a7424adec7310657a590f675d3</citedby><cites>FETCH-LOGICAL-c445t-824694144ecb8dbba435f77365f1e5121d30c13a7424adec7310657a590f675d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0165247810001768$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20637236$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>González, Delia Almeida</creatorcontrib><creatorcontrib>Díaz, Buenaventura Brito</creatorcontrib><creatorcontrib>Rodríguez Pérez, María del Cristo</creatorcontrib><creatorcontrib>Hernández, Ana González</creatorcontrib><creatorcontrib>Chico, B. Nicolás Díaz</creatorcontrib><creatorcontrib>de León, Antonio Cabrera</creatorcontrib><title>Sex hormones and autoimmunity</title><title>Immunology letters</title><addtitle>Immunol Lett</addtitle><description>Abstract Autoimmune diseases occur more in women than in men, and this may be attributable to the role of estrogens. Androgens promote autoimmune diseases with a profile of type 1 cytokines, such as rheumatoid arthritis, whereas estrogens promote autoimmune diseases with a type 2 cytokine profile, like systemic lupus erythematosus. Both androgens and estrogens regulate the Th1/Th2 balance. Type 1 autoimmune diseases are improved when decrease type 1 cytokines (i.e. during fasting), or when there is a rise in type 2 cytokines (increased estrogens, as in pregnancy). Type 2 autoimmune diseases improve when type 2 cytokines are diminished (decreased estrogen, as in post-partum period) or when type 1 response is stimulated.</description><subject>Allergy and Immunology</subject><subject>Androgens</subject><subject>Androgens - immunology</subject><subject>Androgens - metabolism</subject><subject>Animals</subject><subject>Arthritis, Rheumatoid - epidemiology</subject><subject>Arthritis, Rheumatoid - immunology</subject><subject>Autoimmune diseases</subject><subject>Autoimmunity</subject><subject>Cytokines</subject><subject>Estrogens - immunology</subject><subject>Estrogens - metabolism</subject><subject>Female</subject><subject>Humans</subject><subject>Lupus Erythematosus, Systemic - epidemiology</subject><subject>Lupus Erythematosus, Systemic - immunology</subject><subject>Male</subject><subject>Pregnancy - immunology</subject><subject>Sex Factors</subject><subject>Sex hormones</subject><subject>Systemic lupus erythematosus</subject><subject>Th1-Th2 Balance</subject><issn>0165-2478</issn><issn>1879-0542</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkctKAzEUhoMotlafQJTuXM2Ye2YWClK8QcFFdR3SzBnMOJeazIh9e1OrLtx0deDw_efA9yN0SnBKMJGXVeqaGvqU4rjBKsWY7KExyVSeYMHpPhpHSiSUq2yEjkKoIiAYZ4doRLFkijI5RmcL-Jy-dr7pWghT0xZTM_Sda5qhdf36GB2Upg5w8jMn6OXu9nn2kMyf7h9nN_PEci76JKNc5pxwDnaZFcul4UyUSjEpSgKCUFIwbAkzilNuCrCKESyFMiLHpVSiYBN0sb278t37AKHXjQsW6tq00A1BZ0QIJriUO0nFc0woz1kk2Za0vgvBQ6lX3jXGrzXBeiNQV_pboN4I1Fjp6Cemzn_uD8sGir_Mr7EIXG0BiD4-HHgdrIPWQuE82F4Xndvx4Ppf3tauddbUb7CGUHWDb6NqTXSgGuvFpsNNhQTHtJIZ-wKcNZRW</recordid><startdate>20100906</startdate><enddate>20100906</enddate><creator>González, Delia Almeida</creator><creator>Díaz, Buenaventura Brito</creator><creator>Rodríguez Pérez, María del Cristo</creator><creator>Hernández, Ana González</creator><creator>Chico, B. 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Nicolás Díaz ; de León, Antonio Cabrera</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c445t-824694144ecb8dbba435f77365f1e5121d30c13a7424adec7310657a590f675d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Allergy and Immunology</topic><topic>Androgens</topic><topic>Androgens - immunology</topic><topic>Androgens - metabolism</topic><topic>Animals</topic><topic>Arthritis, Rheumatoid - epidemiology</topic><topic>Arthritis, Rheumatoid - immunology</topic><topic>Autoimmune diseases</topic><topic>Autoimmunity</topic><topic>Cytokines</topic><topic>Estrogens - immunology</topic><topic>Estrogens - metabolism</topic><topic>Female</topic><topic>Humans</topic><topic>Lupus Erythematosus, Systemic - epidemiology</topic><topic>Lupus Erythematosus, Systemic - immunology</topic><topic>Male</topic><topic>Pregnancy - immunology</topic><topic>Sex Factors</topic><topic>Sex hormones</topic><topic>Systemic lupus erythematosus</topic><topic>Th1-Th2 Balance</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>González, Delia Almeida</creatorcontrib><creatorcontrib>Díaz, Buenaventura Brito</creatorcontrib><creatorcontrib>Rodríguez Pérez, María del Cristo</creatorcontrib><creatorcontrib>Hernández, Ana González</creatorcontrib><creatorcontrib>Chico, B. 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| ispartof | Immunology letters, 2010-09, Vol.133 (1), p.6-13 |
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| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Allergy and Immunology Androgens Androgens - immunology Androgens - metabolism Animals Arthritis, Rheumatoid - epidemiology Arthritis, Rheumatoid - immunology Autoimmune diseases Autoimmunity Cytokines Estrogens - immunology Estrogens - metabolism Female Humans Lupus Erythematosus, Systemic - epidemiology Lupus Erythematosus, Systemic - immunology Male Pregnancy - immunology Sex Factors Sex hormones Systemic lupus erythematosus Th1-Th2 Balance |
| title | Sex hormones and autoimmunity |
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