Licensed to elongate: a molecular mechanism for MLL-based leukaemogenesis

This article discusses the possible function of the super elongation complex (SEC) and the DOT1 H3K79 methyltransferase complex (DotCom) in leukaemia that is induced by translocation of mixed lineage leukaemia ( MLL ). The RNA polymerase II (Pol II) elongation factor (ELL) was the first translocatio...

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Veröffentlicht in:	Nature reviews. Cancer 2010-10, Vol.10 (10), p.721-728
Hauptverfasser:	Shilatifard, Ali, Mohan, Man, Lin, Chengqi, Guest, Erin
Format:	Artikel
Sprache:	eng
Schlagworte:	631/208/2489/1381/1853 692/420/755 692/699/67/1990/283 Biomedical and Life Sciences Biomedicine Cancer Research Care and treatment Development and progression Genetic aspects Histone-Lysine N-Methyltransferase Humans Leukemia Leukemia - genetics Myeloid-Lymphoid Leukemia Protein - genetics Myeloid-Lymphoid Leukemia Protein - physiology perspectives Physiological aspects Risk factors RNA polymerases Transcription factors Transcription, Genetic - physiology Translocation, Genetic
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