Effect of combining ACE inhibitor and statin in lupus-prone mice

Abstract MRL-Faslpr mice spontaneously develop a systemic autoimmune disease resembling human systemic lupus erythematosus. The glomerulonephritis in MRL-Faslpr mice is mediated by autoantibodies and autoreactive lymphocytes. To investigate the effect of combination therapy by angiotensin-converting...

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Veröffentlicht in:	Clinical immunology (Orlando, Fla.) Fla.), 2010-08, Vol.136 (2), p.188-196
Hauptverfasser:	Shimazu, Hideki, Kinoshita, Koji, Hino, Shoichi, Yano, Tomohiro, Kishimoto, Kazuya, Nagare, Yasuaki, Nozaki, Yuji, Sugiyama, Masafumi, Ikoma, Shinya, Funauchi, Masanori
Format:	Artikel
Sprache:	eng
Schlagworte:	ACEI Allergy and Immunology Angiotensin-Converting Enzyme Inhibitors - administration & dosage Animals Antibodies, Antinuclear - blood Biological and medical sciences Blood Pressure Cytokines - metabolism Drug Therapy, Combination Female Fundamental and applied biological sciences. Psychology Fundamental immunology Hydroxymethylglutaryl-CoA Reductase Inhibitors - administration & dosage Imidazolidines - administration & dosage Immunoglobulin G - metabolism Kidney Kidney - immunology Kidney - metabolism Kidney - pathology Lupus Lupus Erythematosus, Systemic - drug therapy Lupus Erythematosus, Systemic - immunology Lupus Nephritis - drug therapy Lupus Nephritis - immunology Medical sciences Mice Mice, Inbred C3H Mice, Inbred MRL lpr Nephritis Pravastatin - administration & dosage Proteinuria - drug therapy Proteinuria - prevention & control Random Allocation Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis Specific Pathogen-Free Organisms Statin
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