Expressional and functional studies of CKLF1 during dendritic cell maturation
Chemokine-like factor 1 (CKLF1) was the first member of the CKLF-like MARVEL transmembrane domain containing member (CMTM) family to be discovered. Its expression level is increased clearly in peripheral blood lymphocytes upon phytohemagglutinin stimulation, but little is known about the expression...
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| Veröffentlicht in: | Cellular immunology 2010, Vol.263 (2), p.188-195 |
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| container_title | Cellular immunology |
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| creator | Shao, Luning Li, Ting Mo, Xiaoning Majdic, Otto Zhang, Yanfei Seyerl, Maria Schrauf, Catharina Ma, Dalong Stöckl, Johannes Han, Wenling |
| description | Chemokine-like factor 1 (CKLF1) was the first member of the CKLF-like MARVEL transmembrane domain containing member (CMTM) family to be discovered. Its expression level is increased clearly in peripheral blood lymphocytes upon phytohemagglutinin stimulation, but little is known about the expression and function of CKLF1 in dendritic cells (DCs), which are the most potent antigen-presenting cells. In the present study, we showed that CKLF1 was highly expressed in monocytes. During differentiation from monocytes to immature DCs, CKLF1 was increased dramatically on day 2 and then decreased from day 3 to 5. Upon maturation with different stimuli, CKLF1 was down-regulated. Two peptides of CKLF1, C19 and C27, stimulated the effect of immature DCs (imDCs) on T-cell proliferation and IFN-γ production. Further study on DC maturation showed that C19 and C27 up-regulated HLA-DR expression and IL-12 secretion, with no obvious effects on CD80, CD83 or CD86. Thus, CKLF1-C19 and -C27 can stimulate antigen-presenting capability of imDCs. |
| doi_str_mv | 10.1016/j.cellimm.2010.03.015 |
| format | Article |
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Its expression level is increased clearly in peripheral blood lymphocytes upon phytohemagglutinin stimulation, but little is known about the expression and function of CKLF1 in dendritic cells (DCs), which are the most potent antigen-presenting cells. In the present study, we showed that CKLF1 was highly expressed in monocytes. During differentiation from monocytes to immature DCs, CKLF1 was increased dramatically on day 2 and then decreased from day 3 to 5. Upon maturation with different stimuli, CKLF1 was down-regulated. Two peptides of CKLF1, C19 and C27, stimulated the effect of immature DCs (imDCs) on T-cell proliferation and IFN-γ production. Further study on DC maturation showed that C19 and C27 up-regulated HLA-DR expression and IL-12 secretion, with no obvious effects on CD80, CD83 or CD86. Thus, CKLF1-C19 and -C27 can stimulate antigen-presenting capability of imDCs.</description><identifier>ISSN: 0008-8749</identifier><identifier>EISSN: 1090-2163</identifier><identifier>DOI: 10.1016/j.cellimm.2010.03.015</identifier><identifier>PMID: 20392439</identifier><language>eng</language><publisher>Netherlands: Elsevier Inc</publisher><subject>Antigen-presenting cells ; Cell Differentiation - drug effects ; Chemokine-like factor 1 ; Chemokines - metabolism ; Chemokines - pharmacology ; Dendritic cell ; Dendritic Cells - cytology ; Dendritic Cells - drug effects ; Dendritic Cells - immunology ; Down-Regulation ; Gene Expression Regulation ; HLA-DR ; Humans ; IFN-γ ; IL-12 ; Interleukin-12 - secretion ; Leukocytes, Mononuclear - cytology ; Leukocytes, Mononuclear - immunology ; MARVEL Domain-Containing Proteins</subject><ispartof>Cellular immunology, 2010, Vol.263 (2), p.188-195</ispartof><rights>2010</rights><rights>Crown Copyright (c) 2010. Published by Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c396t-9d6820c0c69418b53fdee4bb061afce0e07ed7d3e25d5a005a52979f67cafc473</citedby><cites>FETCH-LOGICAL-c396t-9d6820c0c69418b53fdee4bb061afce0e07ed7d3e25d5a005a52979f67cafc473</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.cellimm.2010.03.015$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,4024,27923,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20392439$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Shao, Luning</creatorcontrib><creatorcontrib>Li, Ting</creatorcontrib><creatorcontrib>Mo, Xiaoning</creatorcontrib><creatorcontrib>Majdic, Otto</creatorcontrib><creatorcontrib>Zhang, Yanfei</creatorcontrib><creatorcontrib>Seyerl, Maria</creatorcontrib><creatorcontrib>Schrauf, Catharina</creatorcontrib><creatorcontrib>Ma, Dalong</creatorcontrib><creatorcontrib>Stöckl, Johannes</creatorcontrib><creatorcontrib>Han, Wenling</creatorcontrib><title>Expressional and functional studies of CKLF1 during dendritic cell maturation</title><title>Cellular immunology</title><addtitle>Cell Immunol</addtitle><description>Chemokine-like factor 1 (CKLF1) was the first member of the CKLF-like MARVEL transmembrane domain containing member (CMTM) family to be discovered. 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Thus, CKLF1-C19 and -C27 can stimulate antigen-presenting capability of imDCs.</description><subject>Antigen-presenting cells</subject><subject>Cell Differentiation - drug effects</subject><subject>Chemokine-like factor 1</subject><subject>Chemokines - metabolism</subject><subject>Chemokines - pharmacology</subject><subject>Dendritic cell</subject><subject>Dendritic Cells - cytology</subject><subject>Dendritic Cells - drug effects</subject><subject>Dendritic Cells - immunology</subject><subject>Down-Regulation</subject><subject>Gene Expression Regulation</subject><subject>HLA-DR</subject><subject>Humans</subject><subject>IFN-γ</subject><subject>IL-12</subject><subject>Interleukin-12 - secretion</subject><subject>Leukocytes, Mononuclear - cytology</subject><subject>Leukocytes, Mononuclear - immunology</subject><subject>MARVEL Domain-Containing Proteins</subject><issn>0008-8749</issn><issn>1090-2163</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE1PwzAMhiMEYmPwE0C9cWpxkqZtTghNGyCGuMA5ShMXZerHSFoE_55WG1w5RY6f17YeQi4pJBRodrNNDNa1a5qEwfgHPAEqjsicgoSY0YwfkzkAFHGRp3JGzkLYAlCaSjglMwZcspTLOXlefe08huC6VteRbm1UDa3p92XoB-swRF0VLZ82axrZwbv2PbLYWu96Z6LphqjR_eD1lDknJ5WuA14c3gV5W69elw_x5uX-cXm3iQ2XWR9LmxUMDJhMprQoBa8sYlqWkFFdGQSEHG1uOTJhhQYQWjCZyyrLzdhPc74g1_u5O999DBh61bgw3aJb7IagCioEZxkt_iVzzlnBgU-k2JPGdyF4rNTOu0b7b0VBTcrVVh2Uq0m5Aq5G5WPu6rBhKBu0f6lfxyNwuwdwNPLp0KtgHLYGrfNoemU798-KH4nYlPY</recordid><startdate>2010</startdate><enddate>2010</enddate><creator>Shao, Luning</creator><creator>Li, Ting</creator><creator>Mo, Xiaoning</creator><creator>Majdic, Otto</creator><creator>Zhang, Yanfei</creator><creator>Seyerl, Maria</creator><creator>Schrauf, Catharina</creator><creator>Ma, Dalong</creator><creator>Stöckl, Johannes</creator><creator>Han, Wenling</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7T5</scope><scope>H94</scope></search><sort><creationdate>2010</creationdate><title>Expressional and functional studies of CKLF1 during dendritic cell maturation</title><author>Shao, Luning ; 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Its expression level is increased clearly in peripheral blood lymphocytes upon phytohemagglutinin stimulation, but little is known about the expression and function of CKLF1 in dendritic cells (DCs), which are the most potent antigen-presenting cells. In the present study, we showed that CKLF1 was highly expressed in monocytes. During differentiation from monocytes to immature DCs, CKLF1 was increased dramatically on day 2 and then decreased from day 3 to 5. Upon maturation with different stimuli, CKLF1 was down-regulated. Two peptides of CKLF1, C19 and C27, stimulated the effect of immature DCs (imDCs) on T-cell proliferation and IFN-γ production. Further study on DC maturation showed that C19 and C27 up-regulated HLA-DR expression and IL-12 secretion, with no obvious effects on CD80, CD83 or CD86. 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| subjects | Antigen-presenting cells Cell Differentiation - drug effects Chemokine-like factor 1 Chemokines - metabolism Chemokines - pharmacology Dendritic cell Dendritic Cells - cytology Dendritic Cells - drug effects Dendritic Cells - immunology Down-Regulation Gene Expression Regulation HLA-DR Humans IFN-γ IL-12 Interleukin-12 - secretion Leukocytes, Mononuclear - cytology Leukocytes, Mononuclear - immunology MARVEL Domain-Containing Proteins |
| title | Expressional and functional studies of CKLF1 during dendritic cell maturation |
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