HIV-1 Nef associates with p22-phox, a component of the NADPH oxidase protein complex

Altered neutrophil function may contribute to the development of AIDS during the course of HIV infection. It has been described that Nef, a regulatory protein from HIV, can modulate superoxide production in other cells, therefore altered superoxide production in neutrophils from HIV infected patient...

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Veröffentlicht in:	Cellular immunology 2010, Vol.263 (2), p.166-171
Hauptverfasser:	Salmen, Siham, Colmenares, Melisa, Peterson, Darrel L., Reyes, Elbert, Rosales, Jose D., Berrueta, Lisbeth
Format:	Artikel
Sprache:	eng
Schlagworte:	Acquired immune deficiency syndrome Cloning, Molecular Flow Cytometry Fluorescent Antibody Technique HIV HIV-1 - metabolism HIV-1 - pathogenicity Human immunodeficiency virus 1 Humans Multienzyme Complexes NADH, NADPH Oxidoreductases - metabolism NADPH oxidase NADPH Oxidase 1 NADPH Oxidases - metabolism Nef nef Gene Products, Human Immunodeficiency Virus - metabolism Neutrophils p22-phox Superoxide
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