Mechanism of peruvoside-induced emesis
Peruvoside causes emesis in dogs and cats by oral or intravenous routes. There is no species difference and effective emetic doses in either species did not differ significantly. Decerebrate cats vomit after intravenous administration of peruvoside. Intraventricular or intracistemal administration o...
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| Veröffentlicht in: | Neuropharmacology 1972-05, Vol.11 (3), p.427-433 |
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| creator | Gaitonde, B.B. Joglekar, S.N. |
| description | Peruvoside causes emesis in dogs and cats by oral or intravenous routes. There is no species difference and effective emetic doses in either species did not differ significantly. Decerebrate cats vomit after intravenous administration of peruvoside. Intraventricular or intracistemal administration of the drug does not cause emesis but a typical “digitalis toxicity syndrome” is seen. The ablation of the chemoreceptor trigger zone fails to eliminate peruvosideinduced emesis, but nodose ganglionectomy eliminates this response. Intracarotid injections of the drug considerably reduce the threshold latency in eliciting emesis. We conclude that peruvoside stimulates receptors in the nodose ganglion to produce emesis. |
| doi_str_mv | 10.1016/0028-3908(72)90028-7 |
| format | Article |
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There is no species difference and effective emetic doses in either species did not differ significantly. Decerebrate cats vomit after intravenous administration of peruvoside. Intraventricular or intracistemal administration of the drug does not cause emesis but a typical “digitalis toxicity syndrome” is seen. The ablation of the chemoreceptor trigger zone fails to eliminate peruvosideinduced emesis, but nodose ganglionectomy eliminates this response. Intracarotid injections of the drug considerably reduce the threshold latency in eliciting emesis. We conclude that peruvoside stimulates receptors in the nodose ganglion to produce emesis.</description><identifier>ISSN: 0028-3908</identifier><identifier>EISSN: 1873-7064</identifier><identifier>DOI: 10.1016/0028-3908(72)90028-7</identifier><identifier>PMID: 5065716</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>Administration, Oral ; Animals ; Brain - physiology ; Cardanolides - pharmacology ; Cardiac Glycosides - administration & dosage ; Cardiac Glycosides - pharmacology ; Cats ; Chemoreceptor Cells - drug effects ; Chemoreceptor Cells - physiology ; Dogs ; Emetics - administration & dosage ; Female ; Injections ; Injections, Intra-Arterial ; Injections, Intravenous ; Male ; Ouabain ; Protoveratrines ; Rabbits ; Time Factors ; Vagotomy ; Vagus Nerve - physiology ; Vomiting - chemically induced</subject><ispartof>Neuropharmacology, 1972-05, Vol.11 (3), p.427-433</ispartof><rights>1972</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c357t-caa21b681ca9586efc6541454a7d249aa7ae52539b2feb8fb961a37d96619dc3</citedby><cites>FETCH-LOGICAL-c357t-caa21b681ca9586efc6541454a7d249aa7ae52539b2feb8fb961a37d96619dc3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/0028390872900287$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3536,27903,27904,65309</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/5065716$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Gaitonde, B.B.</creatorcontrib><creatorcontrib>Joglekar, S.N.</creatorcontrib><title>Mechanism of peruvoside-induced emesis</title><title>Neuropharmacology</title><addtitle>Neuropharmacology</addtitle><description>Peruvoside causes emesis in dogs and cats by oral or intravenous routes. There is no species difference and effective emetic doses in either species did not differ significantly. Decerebrate cats vomit after intravenous administration of peruvoside. Intraventricular or intracistemal administration of the drug does not cause emesis but a typical “digitalis toxicity syndrome” is seen. The ablation of the chemoreceptor trigger zone fails to eliminate peruvosideinduced emesis, but nodose ganglionectomy eliminates this response. Intracarotid injections of the drug considerably reduce the threshold latency in eliciting emesis. We conclude that peruvoside stimulates receptors in the nodose ganglion to produce emesis.</description><subject>Administration, Oral</subject><subject>Animals</subject><subject>Brain - physiology</subject><subject>Cardanolides - pharmacology</subject><subject>Cardiac Glycosides - administration & dosage</subject><subject>Cardiac Glycosides - pharmacology</subject><subject>Cats</subject><subject>Chemoreceptor Cells - drug effects</subject><subject>Chemoreceptor Cells - physiology</subject><subject>Dogs</subject><subject>Emetics - administration & dosage</subject><subject>Female</subject><subject>Injections</subject><subject>Injections, Intra-Arterial</subject><subject>Injections, Intravenous</subject><subject>Male</subject><subject>Ouabain</subject><subject>Protoveratrines</subject><subject>Rabbits</subject><subject>Time Factors</subject><subject>Vagotomy</subject><subject>Vagus Nerve - physiology</subject><subject>Vomiting - chemically induced</subject><issn>0028-3908</issn><issn>1873-7064</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1972</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kElLA0EQhRtR4hj9Bwo5BT2M9r5cBAluEPGSe9PTXYMtmZnYnQn4750s5OipKOq9V7wPoWuC7wkm8gFjqktmsL5V9M7sNnWCCqIVKxWW_BQVR8k5usj5G2PMNdEjNBJYCkVkgaYf4L9cG3Mz6erJClK_6XIMUMY29B7CBBrIMV-is9otM1wd5hgtXp4Xs7dy_vn6Pnual54JtS69c5RUUhPvjNASai8FJ1xwpwLlxjnlQFDBTEVrqHRdGUkcU8FISUzwbIym-9hV6n56yGvbxOxhuXQtdH22mghBmWaDkO-FPnU5J6jtKsXGpV9LsN3SsdvqdlvdKmp3dKwabDeH_L5qIBxNBxzD_XF_h6HjJkKy2UdoBw4xgV_b0MX_H_wBFl1ymQ</recordid><startdate>197205</startdate><enddate>197205</enddate><creator>Gaitonde, B.B.</creator><creator>Joglekar, S.N.</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>197205</creationdate><title>Mechanism of peruvoside-induced emesis</title><author>Gaitonde, B.B. ; Joglekar, S.N.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c357t-caa21b681ca9586efc6541454a7d249aa7ae52539b2feb8fb961a37d96619dc3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1972</creationdate><topic>Administration, Oral</topic><topic>Animals</topic><topic>Brain - physiology</topic><topic>Cardanolides - pharmacology</topic><topic>Cardiac Glycosides - administration & dosage</topic><topic>Cardiac Glycosides - pharmacology</topic><topic>Cats</topic><topic>Chemoreceptor Cells - drug effects</topic><topic>Chemoreceptor Cells - physiology</topic><topic>Dogs</topic><topic>Emetics - administration & dosage</topic><topic>Female</topic><topic>Injections</topic><topic>Injections, Intra-Arterial</topic><topic>Injections, Intravenous</topic><topic>Male</topic><topic>Ouabain</topic><topic>Protoveratrines</topic><topic>Rabbits</topic><topic>Time Factors</topic><topic>Vagotomy</topic><topic>Vagus Nerve - physiology</topic><topic>Vomiting - chemically induced</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Gaitonde, B.B.</creatorcontrib><creatorcontrib>Joglekar, S.N.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Neuropharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Gaitonde, B.B.</au><au>Joglekar, S.N.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Mechanism of peruvoside-induced emesis</atitle><jtitle>Neuropharmacology</jtitle><addtitle>Neuropharmacology</addtitle><date>1972-05</date><risdate>1972</risdate><volume>11</volume><issue>3</issue><spage>427</spage><epage>433</epage><pages>427-433</pages><issn>0028-3908</issn><eissn>1873-7064</eissn><abstract>Peruvoside causes emesis in dogs and cats by oral or intravenous routes. There is no species difference and effective emetic doses in either species did not differ significantly. Decerebrate cats vomit after intravenous administration of peruvoside. Intraventricular or intracistemal administration of the drug does not cause emesis but a typical “digitalis toxicity syndrome” is seen. The ablation of the chemoreceptor trigger zone fails to eliminate peruvosideinduced emesis, but nodose ganglionectomy eliminates this response. Intracarotid injections of the drug considerably reduce the threshold latency in eliciting emesis. We conclude that peruvoside stimulates receptors in the nodose ganglion to produce emesis.</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>5065716</pmid><doi>10.1016/0028-3908(72)90028-7</doi><tpages>7</tpages></addata></record> |
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| identifier | ISSN: 0028-3908 |
| ispartof | Neuropharmacology, 1972-05, Vol.11 (3), p.427-433 |
| issn | 0028-3908 1873-7064 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Administration, Oral Animals Brain - physiology Cardanolides - pharmacology Cardiac Glycosides - administration & dosage Cardiac Glycosides - pharmacology Cats Chemoreceptor Cells - drug effects Chemoreceptor Cells - physiology Dogs Emetics - administration & dosage Female Injections Injections, Intra-Arterial Injections, Intravenous Male Ouabain Protoveratrines Rabbits Time Factors Vagotomy Vagus Nerve - physiology Vomiting - chemically induced |
| title | Mechanism of peruvoside-induced emesis |
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