Influence of Inotropic Alteration on the Severity of Myocardial Ischemia after Experimental Coronary Occlusion
The effects of propranolol (0.5-2mg./Kg.) and isoproterenol (0.2μg./Kg./min.) on the severity and extent of ischemic injury after acute coronary occlusion in experimental dogs were determined from the average S-T segment elevation (E-ST) and the number of sites where S-T elevation exceeded 2mV. (N-S...
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| Veröffentlicht in: | Japanese Heart Journal 1972, Vol.13(3), pp.222-231 |
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| container_title | Japanese Heart Journal |
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| creator | WATANABE, Tan SHINTANI, Fujio FU, Longtai FUJII, Junichi WATANABE, Hiroshi KATO, Kazuzo |
| description | The effects of propranolol (0.5-2mg./Kg.) and isoproterenol (0.2μg./Kg./min.) on the severity and extent of ischemic injury after acute coronary occlusion in experimental dogs were determined from the average S-T segment elevation (E-ST) and the number of sites where S-T elevation exceeded 2mV. (N-ST) in 12 to 20 left ventricular (LV) epicardial sites. The mappings were obtained 15min. after repetitive occlusions of a main branch of the left anterior descending coronary artery. In 5 dogs propranolol decreased E-ST from 4.0±0.8 during simple control occlusion to 1.5±0.3mV. (SEM) (p |
| doi_str_mv | 10.1536/ihj.13.222 |
| format | Article |
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(N-ST) in 12 to 20 left ventricular (LV) epicardial sites. The mappings were obtained 15min. after repetitive occlusions of a main branch of the left anterior descending coronary artery. In 5 dogs propranolol decreased E-ST from 4.0±0.8 during simple control occlusion to 1.5±0.3mV. (SEM) (p<0.01) and N-ST from 9.2±1.0 to 4.2±0.5 (p<0.01). At this time, LV myocardial contractility expressed by dP/dt/IIT decreased from 2, 320±280 to 1, 460±230 (p<0.01) along with significant reduction of cardiac output (CO). LV developed tension assessed from LV TTI/min. fell slightly and insignificantly. In contrast, in 5 dogs the infusion of isoproterenol increased E-ST from 1.5±0.2 to 3.1±0.7mV. and N-ST from 6.6±0.6 to 9.4±1.1 (both, p<0.01). The value of dP/dt/IIT increased from 1, 980±440 to 4, 610±920 (p<0.01) with concomitant increment in CO. LV TTI/min. elevated slightly and again insignificantly. It was concluded that, in beating in situ heart the severity and extent of acute myocardial ischemic injury can be altered by the changes in LV contractile state, even in the absence of changes in LV wall tension.</description><identifier>ISSN: 0021-4868</identifier><identifier>EISSN: 1348-673X</identifier><identifier>DOI: 10.1536/ihj.13.222</identifier><identifier>PMID: 4538254</identifier><language>eng</language><publisher>Japan: International Heart Journal Association</publisher><subject>Animals ; Cardiac Output - drug effects ; Contractile state ; Coronary Disease - physiopathology ; Dogs ; Electrocardiography ; Epicardial mapping ; Heart - drug effects ; Heart Rate - drug effects ; Ischemia ; Isoproterenol ; Isoproterenol - pharmacology ; Muscle Contraction - drug effects ; Myocardial oxygen demand and supply ; Perfusion ; Propranolol ; Propranolol - pharmacology ; Wall tension</subject><ispartof>Japanese Heart Journal, 1972, Vol.13(3), pp.222-231</ispartof><rights>by International Heart Journal Association</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c545t-87b64eba1c9ffd267d48f3a913fb115d5f06d56487566f6d016c1485f0d135ef3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,1877,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/4538254$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>WATANABE, Tan</creatorcontrib><creatorcontrib>SHINTANI, Fujio</creatorcontrib><creatorcontrib>FU, Longtai</creatorcontrib><creatorcontrib>FUJII, Junichi</creatorcontrib><creatorcontrib>WATANABE, Hiroshi</creatorcontrib><creatorcontrib>KATO, Kazuzo</creatorcontrib><title>Influence of Inotropic Alteration on the Severity of Myocardial Ischemia after Experimental Coronary Occlusion</title><title>Japanese Heart Journal</title><addtitle>Jpn Heart J</addtitle><description>The effects of propranolol (0.5-2mg./Kg.) and isoproterenol (0.2μg./Kg./min.) on the severity and extent of ischemic injury after acute coronary occlusion in experimental dogs were determined from the average S-T segment elevation (E-ST) and the number of sites where S-T elevation exceeded 2mV. (N-ST) in 12 to 20 left ventricular (LV) epicardial sites. The mappings were obtained 15min. after repetitive occlusions of a main branch of the left anterior descending coronary artery. In 5 dogs propranolol decreased E-ST from 4.0±0.8 during simple control occlusion to 1.5±0.3mV. (SEM) (p<0.01) and N-ST from 9.2±1.0 to 4.2±0.5 (p<0.01). At this time, LV myocardial contractility expressed by dP/dt/IIT decreased from 2, 320±280 to 1, 460±230 (p<0.01) along with significant reduction of cardiac output (CO). LV developed tension assessed from LV TTI/min. fell slightly and insignificantly. In contrast, in 5 dogs the infusion of isoproterenol increased E-ST from 1.5±0.2 to 3.1±0.7mV. and N-ST from 6.6±0.6 to 9.4±1.1 (both, p<0.01). The value of dP/dt/IIT increased from 1, 980±440 to 4, 610±920 (p<0.01) with concomitant increment in CO. LV TTI/min. elevated slightly and again insignificantly. It was concluded that, in beating in situ heart the severity and extent of acute myocardial ischemic injury can be altered by the changes in LV contractile state, even in the absence of changes in LV wall tension.</description><subject>Animals</subject><subject>Cardiac Output - drug effects</subject><subject>Contractile state</subject><subject>Coronary Disease - physiopathology</subject><subject>Dogs</subject><subject>Electrocardiography</subject><subject>Epicardial mapping</subject><subject>Heart - drug effects</subject><subject>Heart Rate - drug effects</subject><subject>Ischemia</subject><subject>Isoproterenol</subject><subject>Isoproterenol - pharmacology</subject><subject>Muscle Contraction - drug effects</subject><subject>Myocardial oxygen demand and supply</subject><subject>Perfusion</subject><subject>Propranolol</subject><subject>Propranolol - pharmacology</subject><subject>Wall tension</subject><issn>0021-4868</issn><issn>1348-673X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1972</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kE1rGzEURUVJSZy0m-4LWmURGFdv9GF5GUzSGhKyaAvZCVnzVI8ZS46kCfW_j4yNQUige3R4uoR8AzYFydWPfr2ZAp-2bfuJTIAL3agZf70gE8ZaaIRW-opc57xhDFSr-SW5FJLrVooJCcvghxGDQxo9XYZYUtz1jt4PBZMtfQy0rrJG-hvfMfVlf-Ce99HZ1PV2oMvs1rjtLbW-vqAP_3eV2mIoNVvEFINNe_ri3DDmKvtCPns7ZPx6Om_I38eHP4tfzdPLz-Xi_qlxUsjS6NlKCVxZcHPvu1bNOqE9t3PgfgUgO-mZ6qQSeiaV8qqr_3IgdL3ugEv0_IbcHr27FN9GzMVs--xwGGzAOGajQcqWcajg3RF0Keac0JtdHb_ObICZQ7mmlmuAm1puhb-frONqi90ZPbVZ88Ux3-Ri_-E5t6n0bsCDCuaKHXT8uFXrOXVrmwwG_gG2SY5J</recordid><startdate>19720101</startdate><enddate>19720101</enddate><creator>WATANABE, Tan</creator><creator>SHINTANI, Fujio</creator><creator>FU, Longtai</creator><creator>FUJII, Junichi</creator><creator>WATANABE, Hiroshi</creator><creator>KATO, Kazuzo</creator><general>International Heart Journal Association</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19720101</creationdate><title>Influence of Inotropic Alteration on the Severity of Myocardial Ischemia after Experimental Coronary Occlusion</title><author>WATANABE, Tan ; SHINTANI, Fujio ; FU, Longtai ; FUJII, Junichi ; WATANABE, Hiroshi ; KATO, Kazuzo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c545t-87b64eba1c9ffd267d48f3a913fb115d5f06d56487566f6d016c1485f0d135ef3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1972</creationdate><topic>Animals</topic><topic>Cardiac Output - drug effects</topic><topic>Contractile state</topic><topic>Coronary Disease - physiopathology</topic><topic>Dogs</topic><topic>Electrocardiography</topic><topic>Epicardial mapping</topic><topic>Heart - drug effects</topic><topic>Heart Rate - drug effects</topic><topic>Ischemia</topic><topic>Isoproterenol</topic><topic>Isoproterenol - pharmacology</topic><topic>Muscle Contraction - drug effects</topic><topic>Myocardial oxygen demand and supply</topic><topic>Perfusion</topic><topic>Propranolol</topic><topic>Propranolol - pharmacology</topic><topic>Wall tension</topic><toplevel>online_resources</toplevel><creatorcontrib>WATANABE, Tan</creatorcontrib><creatorcontrib>SHINTANI, Fujio</creatorcontrib><creatorcontrib>FU, Longtai</creatorcontrib><creatorcontrib>FUJII, Junichi</creatorcontrib><creatorcontrib>WATANABE, Hiroshi</creatorcontrib><creatorcontrib>KATO, Kazuzo</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Japanese Heart Journal</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>WATANABE, Tan</au><au>SHINTANI, Fujio</au><au>FU, Longtai</au><au>FUJII, Junichi</au><au>WATANABE, Hiroshi</au><au>KATO, Kazuzo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Influence of Inotropic Alteration on the Severity of Myocardial Ischemia after Experimental Coronary Occlusion</atitle><jtitle>Japanese Heart Journal</jtitle><addtitle>Jpn Heart J</addtitle><date>1972-01-01</date><risdate>1972</risdate><volume>13</volume><issue>3</issue><spage>222</spage><epage>231</epage><pages>222-231</pages><issn>0021-4868</issn><eissn>1348-673X</eissn><abstract>The effects of propranolol (0.5-2mg./Kg.) and isoproterenol (0.2μg./Kg./min.) on the severity and extent of ischemic injury after acute coronary occlusion in experimental dogs were determined from the average S-T segment elevation (E-ST) and the number of sites where S-T elevation exceeded 2mV. (N-ST) in 12 to 20 left ventricular (LV) epicardial sites. The mappings were obtained 15min. after repetitive occlusions of a main branch of the left anterior descending coronary artery. In 5 dogs propranolol decreased E-ST from 4.0±0.8 during simple control occlusion to 1.5±0.3mV. (SEM) (p<0.01) and N-ST from 9.2±1.0 to 4.2±0.5 (p<0.01). At this time, LV myocardial contractility expressed by dP/dt/IIT decreased from 2, 320±280 to 1, 460±230 (p<0.01) along with significant reduction of cardiac output (CO). LV developed tension assessed from LV TTI/min. fell slightly and insignificantly. In contrast, in 5 dogs the infusion of isoproterenol increased E-ST from 1.5±0.2 to 3.1±0.7mV. and N-ST from 6.6±0.6 to 9.4±1.1 (both, p<0.01). The value of dP/dt/IIT increased from 1, 980±440 to 4, 610±920 (p<0.01) with concomitant increment in CO. LV TTI/min. elevated slightly and again insignificantly. It was concluded that, in beating in situ heart the severity and extent of acute myocardial ischemic injury can be altered by the changes in LV contractile state, even in the absence of changes in LV wall tension.</abstract><cop>Japan</cop><pub>International Heart Journal Association</pub><pmid>4538254</pmid><doi>10.1536/ihj.13.222</doi><tpages>10</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Japanese Heart Journal, 1972, Vol.13(3), pp.222-231 |
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| source | MEDLINE; J-STAGE (Japan Science & Technology Information Aggregator, Electronic) Freely Available Titles - Japanese; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Animals Cardiac Output - drug effects Contractile state Coronary Disease - physiopathology Dogs Electrocardiography Epicardial mapping Heart - drug effects Heart Rate - drug effects Ischemia Isoproterenol Isoproterenol - pharmacology Muscle Contraction - drug effects Myocardial oxygen demand and supply Perfusion Propranolol Propranolol - pharmacology Wall tension |
| title | Influence of Inotropic Alteration on the Severity of Myocardial Ischemia after Experimental Coronary Occlusion |
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