Influence of Inotropic Alteration on the Severity of Myocardial Ischemia after Experimental Coronary Occlusion

Influence of Inotropic Alteration on the Severity of Myocardial Ischemia after Experimental Coronary Occlusion

The effects of propranolol (0.5-2mg./Kg.) and isoproterenol (0.2μg./Kg./min.) on the severity and extent of ischemic injury after acute coronary occlusion in experimental dogs were determined from the average S-T segment elevation (E-ST) and the number of sites where S-T elevation exceeded 2mV. (N-S...

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Veröffentlicht in:Japanese Heart Journal 1972, Vol.13(3), pp.222-231
Hauptverfasser: WATANABE, Tan, SHINTANI, Fujio, FU, Longtai, FUJII, Junichi, WATANABE, Hiroshi, KATO, Kazuzo
Format: Artikel
Sprache:eng
Schlagworte:
Animals
Cardiac Output - drug effects
Contractile state
Coronary Disease - physiopathology
Dogs
Electrocardiography
Epicardial mapping
Heart - drug effects
Heart Rate - drug effects
Ischemia
Isoproterenol
Isoproterenol - pharmacology
Muscle Contraction - drug effects
Myocardial oxygen demand and supply
Perfusion
Propranolol
Propranolol - pharmacology
Wall tension
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Zusammenfassung:The effects of propranolol (0.5-2mg./Kg.) and isoproterenol (0.2μg./Kg./min.) on the severity and extent of ischemic injury after acute coronary occlusion in experimental dogs were determined from the average S-T segment elevation (E-ST) and the number of sites where S-T elevation exceeded 2mV. (N-ST) in 12 to 20 left ventricular (LV) epicardial sites. The mappings were obtained 15min. after repetitive occlusions of a main branch of the left anterior descending coronary artery. In 5 dogs propranolol decreased E-ST from 4.0±0.8 during simple control occlusion to 1.5±0.3mV. (SEM) (p
ISSN:0021-4868
1348-673X
DOI:10.1536/ihj.13.222