Chromosome Aberrations caused by Radioactive Thymidine
CHROMOSOME aberrations in onion root tips treated with 2- 14 C-thymine deoxyriboside (thymidine) and with 2- 14 C-thymine have been studied. It has been found that radioactive thymidine gives a significantly higher frequency of aberration than equivalent amounts of radioactive thymine. Since thymidi...
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| Veröffentlicht in: | Nature (London) 1955-06, Vol.175 (4467), p.1038-1039 |
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| container_issue | 4467 |
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| container_title | Nature (London) |
| container_volume | 175 |
| creator | McQUADE, HENRY A FRIEDKIN, MORRIS ATCHISON, ALICE A |
| description | CHROMOSOME aberrations in onion root tips treated with 2-
14
C-thymine deoxyriboside (thymidine) and with 2-
14
C-thymine have been studied. It has been found that radioactive thymidine gives a significantly higher frequency of aberration than equivalent amounts of radioactive thymine. Since thymidine is a precursor of deoxyribonucleic acid thymine
1,2
and becomes a part of the deoxyribonucleic acid structure without diversion to any known cyto-plasmic component including ribonucleic acid, a unique system is available for provoking intranuclear damage. Thymine, on the other hand, is not incorporated into deoxyribonucleic acid
2,3
. Its radiation effects, therefore, have been studied because it enters the cell without becoming a part of deoxyribonucleic acid and thus provides a source of radiation outside the deoxyribonucleic acid molecule. |
| doi_str_mv | 10.1038/1751038b0 |
| format | Article |
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14
C-thymine deoxyriboside (thymidine) and with 2-
14
C-thymine have been studied. It has been found that radioactive thymidine gives a significantly higher frequency of aberration than equivalent amounts of radioactive thymine. Since thymidine is a precursor of deoxyribonucleic acid thymine
1,2
and becomes a part of the deoxyribonucleic acid structure without diversion to any known cyto-plasmic component including ribonucleic acid, a unique system is available for provoking intranuclear damage. Thymine, on the other hand, is not incorporated into deoxyribonucleic acid
2,3
. Its radiation effects, therefore, have been studied because it enters the cell without becoming a part of deoxyribonucleic acid and thus provides a source of radiation outside the deoxyribonucleic acid molecule.</description><identifier>ISSN: 0028-0836</identifier><identifier>EISSN: 1476-4687</identifier><identifier>DOI: 10.1038/1751038b0</identifier><identifier>PMID: 14394101</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>Chromosome Aberrations ; Chromosome Disorders ; Chromosomes - radiation effects ; Humanities and Social Sciences ; letter ; multidisciplinary ; Old Medline ; Radiation ; Science ; Science (multidisciplinary) ; Thymidine ; Thymine - analogs & derivatives</subject><ispartof>Nature (London), 1955-06, Vol.175 (4467), p.1038-1039</ispartof><rights>Springer Nature Limited 1955</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c342t-2c691e0912ae942fd4a8208666d223c042e92ad5f5ca670d55b19aab5c0c62043</citedby><cites>FETCH-LOGICAL-c342t-2c691e0912ae942fd4a8208666d223c042e92ad5f5ca670d55b19aab5c0c62043</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1038/1751038b0$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1038/1751038b0$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,778,782,27907,27908,41471,42540,51302</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/14394101$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>McQUADE, HENRY A</creatorcontrib><creatorcontrib>FRIEDKIN, MORRIS</creatorcontrib><creatorcontrib>ATCHISON, ALICE A</creatorcontrib><title>Chromosome Aberrations caused by Radioactive Thymidine</title><title>Nature (London)</title><addtitle>Nature</addtitle><addtitle>Nature</addtitle><description>CHROMOSOME aberrations in onion root tips treated with 2-
14
C-thymine deoxyriboside (thymidine) and with 2-
14
C-thymine have been studied. It has been found that radioactive thymidine gives a significantly higher frequency of aberration than equivalent amounts of radioactive thymine. Since thymidine is a precursor of deoxyribonucleic acid thymine
1,2
and becomes a part of the deoxyribonucleic acid structure without diversion to any known cyto-plasmic component including ribonucleic acid, a unique system is available for provoking intranuclear damage. Thymine, on the other hand, is not incorporated into deoxyribonucleic acid
2,3
. Its radiation effects, therefore, have been studied because it enters the cell without becoming a part of deoxyribonucleic acid and thus provides a source of radiation outside the deoxyribonucleic acid molecule.</description><subject>Chromosome Aberrations</subject><subject>Chromosome Disorders</subject><subject>Chromosomes - radiation effects</subject><subject>Humanities and Social Sciences</subject><subject>letter</subject><subject>multidisciplinary</subject><subject>Old Medline</subject><subject>Radiation</subject><subject>Science</subject><subject>Science (multidisciplinary)</subject><subject>Thymidine</subject><subject>Thymine - analogs & derivatives</subject><issn>0028-0836</issn><issn>1476-4687</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1955</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpt0F9LwzAUBfAgipvTB7-A9klQqN6kSZo-juE_GAgyn0ua3LqOtZlJK-zb29Gxvfh0Hu6PA_cQck3hkUKinmgqdlnACRlTnsqYS5WekjEAUzGoRI7IRQgrABA05edkRHmScQp0TORs6V3tgqsxmhbovW4r14TI6C6gjYpt9Klt5bRpq1-MFsttXdmqwUtyVup1wKt9TsjXy_Ni9hbPP17fZ9N5bBLO2pgZmVGEjDKNGWel5VoxUFJKy1higDPMmLaiFEbLFKwQBc20LoQBIxnwZELuht6Ndz8dhjavq2BwvdYNui7kigqe8kT18H6AxrsQPJb5xle19tucQr4bJz-M1NubfWlX1GiPcr9KDx4GEPpT840-X7nON_2j_7bdDrjRbefx2HYQf6S8d7E</recordid><startdate>19550611</startdate><enddate>19550611</enddate><creator>McQUADE, HENRY A</creator><creator>FRIEDKIN, MORRIS</creator><creator>ATCHISON, ALICE A</creator><general>Nature Publishing Group UK</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19550611</creationdate><title>Chromosome Aberrations caused by Radioactive Thymidine</title><author>McQUADE, HENRY A ; FRIEDKIN, MORRIS ; ATCHISON, ALICE A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c342t-2c691e0912ae942fd4a8208666d223c042e92ad5f5ca670d55b19aab5c0c62043</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1955</creationdate><topic>Chromosome Aberrations</topic><topic>Chromosome Disorders</topic><topic>Chromosomes - radiation effects</topic><topic>Humanities and Social Sciences</topic><topic>letter</topic><topic>multidisciplinary</topic><topic>Old Medline</topic><topic>Radiation</topic><topic>Science</topic><topic>Science (multidisciplinary)</topic><topic>Thymidine</topic><topic>Thymine - analogs & derivatives</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>McQUADE, HENRY A</creatorcontrib><creatorcontrib>FRIEDKIN, MORRIS</creatorcontrib><creatorcontrib>ATCHISON, ALICE A</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Nature (London)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>McQUADE, HENRY A</au><au>FRIEDKIN, MORRIS</au><au>ATCHISON, ALICE A</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Chromosome Aberrations caused by Radioactive Thymidine</atitle><jtitle>Nature (London)</jtitle><stitle>Nature</stitle><addtitle>Nature</addtitle><date>1955-06-11</date><risdate>1955</risdate><volume>175</volume><issue>4467</issue><spage>1038</spage><epage>1039</epage><pages>1038-1039</pages><issn>0028-0836</issn><eissn>1476-4687</eissn><abstract>CHROMOSOME aberrations in onion root tips treated with 2-
14
C-thymine deoxyriboside (thymidine) and with 2-
14
C-thymine have been studied. It has been found that radioactive thymidine gives a significantly higher frequency of aberration than equivalent amounts of radioactive thymine. Since thymidine is a precursor of deoxyribonucleic acid thymine
1,2
and becomes a part of the deoxyribonucleic acid structure without diversion to any known cyto-plasmic component including ribonucleic acid, a unique system is available for provoking intranuclear damage. Thymine, on the other hand, is not incorporated into deoxyribonucleic acid
2,3
. Its radiation effects, therefore, have been studied because it enters the cell without becoming a part of deoxyribonucleic acid and thus provides a source of radiation outside the deoxyribonucleic acid molecule.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>14394101</pmid><doi>10.1038/1751038b0</doi><tpages>2</tpages></addata></record> |
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| ispartof | Nature (London), 1955-06, Vol.175 (4467), p.1038-1039 |
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| language | eng |
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| source | MEDLINE; Nature Journals Online; SpringerLink Journals - AutoHoldings |
| subjects | Chromosome Aberrations Chromosome Disorders Chromosomes - radiation effects Humanities and Social Sciences letter multidisciplinary Old Medline Radiation Science Science (multidisciplinary) Thymidine Thymine - analogs & derivatives |
| title | Chromosome Aberrations caused by Radioactive Thymidine |
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