The occurrence of congenital hypoplastic anemia in half brothers
A family is reported in which four childrenof the same father and two unrelated mothers are affected with congenital hypoplastic anemia. This further supports an autosomal dominant mode of inheritance of this disorder. The father and the younger two siblings have elevated concentrations of hemoglobi...
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| Veröffentlicht in: | The Journal of pediatrics 1972-08, Vol.81 (2), p.346-348 |
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| container_title | The Journal of pediatrics |
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| creator | Hunter, Robert E. Hakami, Nasrollah |
| description | A family is reported in which four childrenof the same father and two unrelated mothers are affected with congenital hypoplastic anemia. This further supports an autosomal dominant mode of inheritance of this disorder. The father and the younger two siblings have elevated concentrations of hemoglobin F. If further family studies confirm this as a consistent expression of congenital hypoplastic anemia, it provides a good marker by which to gain more accurate data on which to base genetic counseling for patients affected by this disorder and their families. |
| doi_str_mv | 10.1016/S0022-3476(72)80309-3 |
| format | Article |
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This further supports an autosomal dominant mode of inheritance of this disorder. The father and the younger two siblings have elevated concentrations of hemoglobin F. If further family studies confirm this as a consistent expression of congenital hypoplastic anemia, it provides a good marker by which to gain more accurate data on which to base genetic counseling for patients affected by this disorder and their families.</description><identifier>ISSN: 0022-3476</identifier><identifier>EISSN: 1097-6833</identifier><identifier>DOI: 10.1016/S0022-3476(72)80309-3</identifier><identifier>PMID: 5042496</identifier><language>eng</language><publisher>United States: Mosby, Inc</publisher><subject>Anemia, Aplastic - diagnosis ; Anemia, Aplastic - drug therapy ; Anemia, Aplastic - genetics ; Bone Marrow Examination ; Electrophoresis, Starch Gel ; Erythrocytes, Abnormal ; Erythropoiesis ; Fetal Hemoglobin - analysis ; Humans ; Infant, Newborn ; Male ; Pedigree ; Sex Factors ; Steroids - therapeutic use ; Syndrome</subject><ispartof>The Journal of pediatrics, 1972-08, Vol.81 (2), p.346-348</ispartof><rights>1972 The C. V. 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This further supports an autosomal dominant mode of inheritance of this disorder. The father and the younger two siblings have elevated concentrations of hemoglobin F. If further family studies confirm this as a consistent expression of congenital hypoplastic anemia, it provides a good marker by which to gain more accurate data on which to base genetic counseling for patients affected by this disorder and their families.</description><subject>Anemia, Aplastic - diagnosis</subject><subject>Anemia, Aplastic - drug therapy</subject><subject>Anemia, Aplastic - genetics</subject><subject>Bone Marrow Examination</subject><subject>Electrophoresis, Starch Gel</subject><subject>Erythrocytes, Abnormal</subject><subject>Erythropoiesis</subject><subject>Fetal Hemoglobin - analysis</subject><subject>Humans</subject><subject>Infant, Newborn</subject><subject>Male</subject><subject>Pedigree</subject><subject>Sex Factors</subject><subject>Steroids - therapeutic use</subject><subject>Syndrome</subject><issn>0022-3476</issn><issn>1097-6833</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1972</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkEtLw0AUhQdRaq3-hEJWoovonUcmk5VK8QUFF9b1MJncmJE0qTOJ0H9v0ha3ru6Fc859fITMKdxQoPL2HYCxmItUXqXsWgGHLOZHZEohS2OpOD8m0z_LKTkL4QsAMgEwIZMEBBOZnJL7VYVRa23vPTZ2aMvIts0nNq4zdVRtN-2mNqFzNjINrp2JXBNVpi6j3LddhT6ck5PS1AEvDnVGPp4eV4uXePn2_Lp4WMZWUNbFPJPAUpEUhqEtMGc0ZwWgKKQSqkQlLRdcSUZTwW0qjJW5VRRLmQBXOaV8Ri73cze-_e4xdHrtgsW6Hu5q-6AVTRgIyQdjsjda34bgsdQb79bGbzUFPZLTO3J6xKJTpnfk9JibHxb0-RqLv9QB1aDf7XUcvvxx6HWwbmRWOI-200Xr_tnwC-nnfKg</recordid><startdate>197208</startdate><enddate>197208</enddate><creator>Hunter, Robert E.</creator><creator>Hakami, Nasrollah</creator><general>Mosby, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>197208</creationdate><title>The occurrence of congenital hypoplastic anemia in half brothers</title><author>Hunter, Robert E. ; Hakami, Nasrollah</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c412t-39602745da2ecdeb21b2d0e4d6848fe86c3438621743c74ac6bc81ef65038b113</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1972</creationdate><topic>Anemia, Aplastic - diagnosis</topic><topic>Anemia, Aplastic - drug therapy</topic><topic>Anemia, Aplastic - genetics</topic><topic>Bone Marrow Examination</topic><topic>Electrophoresis, Starch Gel</topic><topic>Erythrocytes, Abnormal</topic><topic>Erythropoiesis</topic><topic>Fetal Hemoglobin - analysis</topic><topic>Humans</topic><topic>Infant, Newborn</topic><topic>Male</topic><topic>Pedigree</topic><topic>Sex Factors</topic><topic>Steroids - therapeutic use</topic><topic>Syndrome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hunter, Robert E.</creatorcontrib><creatorcontrib>Hakami, Nasrollah</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>The Journal of pediatrics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hunter, Robert E.</au><au>Hakami, Nasrollah</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The occurrence of congenital hypoplastic anemia in half brothers</atitle><jtitle>The Journal of pediatrics</jtitle><addtitle>J Pediatr</addtitle><date>1972-08</date><risdate>1972</risdate><volume>81</volume><issue>2</issue><spage>346</spage><epage>348</epage><pages>346-348</pages><issn>0022-3476</issn><eissn>1097-6833</eissn><abstract>A family is reported in which four childrenof the same father and two unrelated mothers are affected with congenital hypoplastic anemia. This further supports an autosomal dominant mode of inheritance of this disorder. The father and the younger two siblings have elevated concentrations of hemoglobin F. If further family studies confirm this as a consistent expression of congenital hypoplastic anemia, it provides a good marker by which to gain more accurate data on which to base genetic counseling for patients affected by this disorder and their families.</abstract><cop>United States</cop><pub>Mosby, Inc</pub><pmid>5042496</pmid><doi>10.1016/S0022-3476(72)80309-3</doi><tpages>3</tpages></addata></record> |
| fulltext | fulltext |
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| ispartof | The Journal of pediatrics, 1972-08, Vol.81 (2), p.346-348 |
| issn | 0022-3476 1097-6833 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Anemia, Aplastic - diagnosis Anemia, Aplastic - drug therapy Anemia, Aplastic - genetics Bone Marrow Examination Electrophoresis, Starch Gel Erythrocytes, Abnormal Erythropoiesis Fetal Hemoglobin - analysis Humans Infant, Newborn Male Pedigree Sex Factors Steroids - therapeutic use Syndrome |
| title | The occurrence of congenital hypoplastic anemia in half brothers |
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