Absence of circulating antibodies to carcinoembryonic antigen in patients with gastrointestinal malignancies
The zirconyl phosphate gel assay (Z‐gel) was used to assay sera of 265 patients for humoral activity against carcinoembryonic antigen (CEA). Included in the patients tested were 110 with non‐metastatic colon carcinoma, 122 with other gastrointestinal, breast and pulmonary neoplasms, 20 pregnant wome...
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| Veröffentlicht in: | International journal of cancer 1972-03, Vol.9 (2), p.344-348 |
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| container_title | International journal of cancer |
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| creator | Gerfo, P. Lo Herter, F. P. Bennett, S. J. |
| description | The zirconyl phosphate gel assay (Z‐gel) was used to assay sera of 265 patients for humoral activity against carcinoembryonic antigen (CEA). Included in the patients tested were 110 with non‐metastatic colon carcinoma, 122 with other gastrointestinal, breast and pulmonary neoplasms, 20 pregnant women and 13 healthy volunteers. Twenty‐five of the patients were also analyzed with molecular filtration column chromatography. Antibody activity directed against CEA could not be detected with either technique. Possible explanations for these results are discussed. |
| doi_str_mv | 10.1002/ijc.2910090212 |
| format | Article |
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Lo ; Herter, F. P. ; Bennett, S. J.</creator><creatorcontrib>Gerfo, P. Lo ; Herter, F. P. ; Bennett, S. J.</creatorcontrib><description>The zirconyl phosphate gel assay (Z‐gel) was used to assay sera of 265 patients for humoral activity against carcinoembryonic antigen (CEA). Included in the patients tested were 110 with non‐metastatic colon carcinoma, 122 with other gastrointestinal, breast and pulmonary neoplasms, 20 pregnant women and 13 healthy volunteers. Twenty‐five of the patients were also analyzed with molecular filtration column chromatography. Antibody activity directed against CEA could not be detected with either technique. Possible explanations for these results are discussed.</description><identifier>ISSN: 0020-7136</identifier><identifier>EISSN: 1097-0215</identifier><identifier>DOI: 10.1002/ijc.2910090212</identifier><identifier>PMID: 5041611</identifier><language>eng</language><publisher>New York: Wiley Subscription Services, Inc., A Wiley Company</publisher><subject>Antibodies - analysis ; Antigens ; Chromatography ; Chromatography, Gel ; Colonic Neoplasms - immunology ; Female ; Gastrointestinal Neoplasms - immunology ; Humans ; Iodine Isotopes ; Pregnancy ; Radioimmunoassay</subject><ispartof>International journal of cancer, 1972-03, Vol.9 (2), p.344-348</ispartof><rights>Copyright © 1972 Wiley‐Liss, Inc., A Wiley Company</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3402-c3c822e24762c350d0254911d8146adbc218895c3c1bd31d591b22331780a273</citedby><cites>FETCH-LOGICAL-c3402-c3c822e24762c350d0254911d8146adbc218895c3c1bd31d591b22331780a273</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fijc.2910090212$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fijc.2910090212$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1416,27923,27924,45573,45574</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/5041611$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Gerfo, P. Lo</creatorcontrib><creatorcontrib>Herter, F. P.</creatorcontrib><creatorcontrib>Bennett, S. J.</creatorcontrib><title>Absence of circulating antibodies to carcinoembryonic antigen in patients with gastrointestinal malignancies</title><title>International journal of cancer</title><addtitle>Int J Cancer</addtitle><description>The zirconyl phosphate gel assay (Z‐gel) was used to assay sera of 265 patients for humoral activity against carcinoembryonic antigen (CEA). Included in the patients tested were 110 with non‐metastatic colon carcinoma, 122 with other gastrointestinal, breast and pulmonary neoplasms, 20 pregnant women and 13 healthy volunteers. Twenty‐five of the patients were also analyzed with molecular filtration column chromatography. Antibody activity directed against CEA could not be detected with either technique. Possible explanations for these results are discussed.</description><subject>Antibodies - analysis</subject><subject>Antigens</subject><subject>Chromatography</subject><subject>Chromatography, Gel</subject><subject>Colonic Neoplasms - immunology</subject><subject>Female</subject><subject>Gastrointestinal Neoplasms - immunology</subject><subject>Humans</subject><subject>Iodine Isotopes</subject><subject>Pregnancy</subject><subject>Radioimmunoassay</subject><issn>0020-7136</issn><issn>1097-0215</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1972</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkD1PwzAURS0EKqWwsiF5Ykvxc-ImHquKj6JKLN0tx3GDK8cudqKq_x5DK2BjeX7SPe_IugjdApkCIfTBbNWU8rRyQoGeoTEQXmZpZ-donACSlZDPLtFVjFtCABgpRmiUJswAxsjO66id0thvsDJBDVb2xrVYut7UvjE64t5jJYMyzuuuDgfvjPqOW-2wcXiXDrTrI96b_h23MvbBG9frmDzS4k5a0zrpVFJdo4uNtFHfnN4JWj89rhcv2ertebmYrzKVF4SmqSpKNS3KGVU5Iw2hrOAATQXFTDa1olBVnCUM6iaHhnGoKc1zKCsiaZlP0P1Ruwv-Y0gfEZ2JSlsrnfZDFBUwYCWHBE6PoAo-xqA3YhdMJ8NBABFf7YrUrvhtNx3cncxD3enmBz_VmXJ-zPfG6sM_NrF8XfxxfwI1HIbZ</recordid><startdate>19720315</startdate><enddate>19720315</enddate><creator>Gerfo, P. 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J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3402-c3c822e24762c350d0254911d8146adbc218895c3c1bd31d591b22331780a273</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1972</creationdate><topic>Antibodies - analysis</topic><topic>Antigens</topic><topic>Chromatography</topic><topic>Chromatography, Gel</topic><topic>Colonic Neoplasms - immunology</topic><topic>Female</topic><topic>Gastrointestinal Neoplasms - immunology</topic><topic>Humans</topic><topic>Iodine Isotopes</topic><topic>Pregnancy</topic><topic>Radioimmunoassay</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Gerfo, P. Lo</creatorcontrib><creatorcontrib>Herter, F. P.</creatorcontrib><creatorcontrib>Bennett, S. 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| ispartof | International journal of cancer, 1972-03, Vol.9 (2), p.344-348 |
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| language | eng |
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| source | MEDLINE; Wiley Online Library All Journals |
| subjects | Antibodies - analysis Antigens Chromatography Chromatography, Gel Colonic Neoplasms - immunology Female Gastrointestinal Neoplasms - immunology Humans Iodine Isotopes Pregnancy Radioimmunoassay |
| title | Absence of circulating antibodies to carcinoembryonic antigen in patients with gastrointestinal malignancies |
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