Vaccination using freeze dried lyophilized BCG in N. Rhodesia
(1) Freeze Dried Lyophilized BCG is not suitable for use in a Mass BCG Vaccination Campaign as the allergy produced following vaccination rapidly disappears twelve months after vaccination. (2) The most satisfactory results from vaccination with Freeze Dried Lyophilized BCG were obtainable when the...
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| Veröffentlicht in: | Tubercle 1955-03, Vol.36 (3), p.81-90 |
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| container_title | Tubercle |
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| creator | Briggs, I.L. |
| description | (1)
Freeze Dried Lyophilized BCG is not suitable for use in a Mass BCG Vaccination Campaign as the allergy produced following vaccination rapidly disappears twelve months after vaccination.
(2)
The most satisfactory results from vaccination with Freeze Dried Lyophilized BCG were obtainable when the 6 mg. ampoule with special diluent was used in a strength of 0·3 mg. per 0·1 ml. given intra-dermally.
(3)
The scarification technique using the 150 mg. ampoule of BCG is totally unsuited for use in the tropics.
(4)
The addition of hyaluronidase to the 6 mg. ampoule of Freeze Dried Lyophilized BCG lowered the effect of vaccination with this vaccine.
(5)
A transient allergy to tuberculin was observed six and eight weeks following vaccination which was not present twelve weeks after vaccination.
(6)
The presence of allergy following vaccination appeared to be influenced by the size of the local reaction at the site of vaccination, the greater the size of local reaction the greater the number showing allergy to tuberculin.
(7)
The diameter of induration indicating a minimal positive reaction to the tuberculin test in Africans of Northern Rhodesia has yet to be determined. |
| doi_str_mv | 10.1016/S0041-3879(55)80070-0 |
| format | Article |
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Freeze Dried Lyophilized BCG is not suitable for use in a Mass BCG Vaccination Campaign as the allergy produced following vaccination rapidly disappears twelve months after vaccination.
(2)
The most satisfactory results from vaccination with Freeze Dried Lyophilized BCG were obtainable when the 6 mg. ampoule with special diluent was used in a strength of 0·3 mg. per 0·1 ml. given intra-dermally.
(3)
The scarification technique using the 150 mg. ampoule of BCG is totally unsuited for use in the tropics.
(4)
The addition of hyaluronidase to the 6 mg. ampoule of Freeze Dried Lyophilized BCG lowered the effect of vaccination with this vaccine.
(5)
A transient allergy to tuberculin was observed six and eight weeks following vaccination which was not present twelve weeks after vaccination.
(6)
The presence of allergy following vaccination appeared to be influenced by the size of the local reaction at the site of vaccination, the greater the size of local reaction the greater the number showing allergy to tuberculin.
(7)
The diameter of induration indicating a minimal positive reaction to the tuberculin test in Africans of Northern Rhodesia has yet to be determined.</description><identifier>ISSN: 0041-3879</identifier><identifier>DOI: 10.1016/S0041-3879(55)80070-0</identifier><identifier>PMID: 14373947</identifier><language>eng</language><publisher>Scotland: Elsevier Ltd</publisher><subject>BCG Vaccine ; Freeze Drying ; Humans ; Mycobacterium bovis ; Old Medline ; Vaccination</subject><ispartof>Tubercle, 1955-03, Vol.36 (3), p.81-90</ispartof><rights>1955</rights><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c278t-345cee51dc9c0823d91506cb22b20f15fe4c9a3f215b5822e91b848ce3fd1d5e3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27903,27904</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/14373947$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Briggs, I.L.</creatorcontrib><title>Vaccination using freeze dried lyophilized BCG in N. Rhodesia</title><title>Tubercle</title><addtitle>Tubercle</addtitle><description>(1)
Freeze Dried Lyophilized BCG is not suitable for use in a Mass BCG Vaccination Campaign as the allergy produced following vaccination rapidly disappears twelve months after vaccination.
(2)
The most satisfactory results from vaccination with Freeze Dried Lyophilized BCG were obtainable when the 6 mg. ampoule with special diluent was used in a strength of 0·3 mg. per 0·1 ml. given intra-dermally.
(3)
The scarification technique using the 150 mg. ampoule of BCG is totally unsuited for use in the tropics.
(4)
The addition of hyaluronidase to the 6 mg. ampoule of Freeze Dried Lyophilized BCG lowered the effect of vaccination with this vaccine.
(5)
A transient allergy to tuberculin was observed six and eight weeks following vaccination which was not present twelve weeks after vaccination.
(6)
The presence of allergy following vaccination appeared to be influenced by the size of the local reaction at the site of vaccination, the greater the size of local reaction the greater the number showing allergy to tuberculin.
(7)
The diameter of induration indicating a minimal positive reaction to the tuberculin test in Africans of Northern Rhodesia has yet to be determined.</description><subject>BCG Vaccine</subject><subject>Freeze Drying</subject><subject>Humans</subject><subject>Mycobacterium bovis</subject><subject>Old Medline</subject><subject>Vaccination</subject><issn>0041-3879</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1955</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkMlOwzAQhn0A0VJ4BFBOCA4pYztunANCUEFBQiCxXa3EHlOjNCl2gtQ-PekiOHKa0ehfNB8hRxSGFOjo_AUgoTGXaXYqxJkESCGGHdL_PffIfgifAEwmI7lHejThKc-StE8u3nOtXZU3rq6iNrjqI7IecYmR8Q5NVC7q-dSVbtnt1-NJ5KrocRg9T2uDweUHZNfmZcDD7RyQt9ub1_Fd_PA0uR9fPcSapbKJeSI0oqBGZxok4yajAka6YKxgYKmwmOgs55ZRUQjJGGa0kInUyK2hRiAfkJNN7tzXXy2GRs1c0FiWeYV1G5Ts8jhP004oNkLt6xA8WjX3bpb7haKgVqzUmpVaQVFCqDUrBZ3veFvQFjM0f64tqE5wuRFg9-a3Q6-CdlhpNM6jbpSp3T8VPzDdec0</recordid><startdate>195503</startdate><enddate>195503</enddate><creator>Briggs, I.L.</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>195503</creationdate><title>Vaccination using freeze dried lyophilized BCG in N. Rhodesia</title><author>Briggs, I.L.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c278t-345cee51dc9c0823d91506cb22b20f15fe4c9a3f215b5822e91b848ce3fd1d5e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1955</creationdate><topic>BCG Vaccine</topic><topic>Freeze Drying</topic><topic>Humans</topic><topic>Mycobacterium bovis</topic><topic>Old Medline</topic><topic>Vaccination</topic><toplevel>online_resources</toplevel><creatorcontrib>Briggs, I.L.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Tubercle</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Briggs, I.L.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Vaccination using freeze dried lyophilized BCG in N. Rhodesia</atitle><jtitle>Tubercle</jtitle><addtitle>Tubercle</addtitle><date>1955-03</date><risdate>1955</risdate><volume>36</volume><issue>3</issue><spage>81</spage><epage>90</epage><pages>81-90</pages><issn>0041-3879</issn><abstract>(1)
Freeze Dried Lyophilized BCG is not suitable for use in a Mass BCG Vaccination Campaign as the allergy produced following vaccination rapidly disappears twelve months after vaccination.
(2)
The most satisfactory results from vaccination with Freeze Dried Lyophilized BCG were obtainable when the 6 mg. ampoule with special diluent was used in a strength of 0·3 mg. per 0·1 ml. given intra-dermally.
(3)
The scarification technique using the 150 mg. ampoule of BCG is totally unsuited for use in the tropics.
(4)
The addition of hyaluronidase to the 6 mg. ampoule of Freeze Dried Lyophilized BCG lowered the effect of vaccination with this vaccine.
(5)
A transient allergy to tuberculin was observed six and eight weeks following vaccination which was not present twelve weeks after vaccination.
(6)
The presence of allergy following vaccination appeared to be influenced by the size of the local reaction at the site of vaccination, the greater the size of local reaction the greater the number showing allergy to tuberculin.
(7)
The diameter of induration indicating a minimal positive reaction to the tuberculin test in Africans of Northern Rhodesia has yet to be determined.</abstract><cop>Scotland</cop><pub>Elsevier Ltd</pub><pmid>14373947</pmid><doi>10.1016/S0041-3879(55)80070-0</doi><tpages>10</tpages></addata></record> |
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| ispartof | Tubercle, 1955-03, Vol.36 (3), p.81-90 |
| issn | 0041-3879 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_81503377 |
| source | MEDLINE; Alma/SFX Local Collection |
| subjects | BCG Vaccine Freeze Drying Humans Mycobacterium bovis Old Medline Vaccination |
| title | Vaccination using freeze dried lyophilized BCG in N. Rhodesia |
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