Effect of Hypoadrenalism and Excessive Doses of Desoxycorticosterone Acetate upon Response of the Rat to Ouabain
The influence of alterations of adrenal function upon the responsiveness of the rat to intravenously administered ouabain was studied electrocardiographically by the string galvanometer. Conduction disturbances followed by cardiac arrest were the criteria for a definitive response. Adrenalectomized...
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| Veröffentlicht in: | Circulation research 1955-05, Vol.3 (3), p.280-284 |
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| container_end_page | 284 |
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| container_title | Circulation research |
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| creator | Unterman, David Degraff, Arthur C Kupperman, Herbert S |
| description | The influence of alterations of adrenal function upon the responsiveness of the rat to intravenously administered ouabain was studied electrocardiographically by the string galvanometer. Conduction disturbances followed by cardiac arrest were the criteria for a definitive response. Adrenalectomized rats showed a significant increase in sensitivity to ouabain as compared with normal controls. Normal animals implanted with pellets of desoxycorticosterone acetate and continuously maintained on saline drinking water did not show a significant alteration in their responsiveness to ouabain. |
| doi_str_mv | 10.1161/01.RES.3.3.280 |
| format | Article |
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Conduction disturbances followed by cardiac arrest were the criteria for a definitive response. Adrenalectomized rats showed a significant increase in sensitivity to ouabain as compared with normal controls. Normal animals implanted with pellets of desoxycorticosterone acetate and continuously maintained on saline drinking water did not show a significant alteration in their responsiveness to ouabain.</description><identifier>ISSN: 0009-7330</identifier><identifier>EISSN: 1524-4571</identifier><identifier>DOI: 10.1161/01.RES.3.3.280</identifier><identifier>PMID: 14364765</identifier><language>eng</language><publisher>United States: American Heart Association, Inc</publisher><subject>Adrenal Glands - surgery ; Adrenal Insufficiency ; Animals ; Desoxycorticosterone - pharmacology ; Desoxycorticosterone Acetate ; Heart - drug effects ; Old Medline ; Ouabain ; Rats ; Strophanthins</subject><ispartof>Circulation research, 1955-05, Vol.3 (3), p.280-284</ispartof><rights>1955 American Heart Association, Inc.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4138-f54af22f85eb628d929a4121924525bd6e49168573d0c76ebefedd1060989c773</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,3687,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/14364765$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Unterman, David</creatorcontrib><creatorcontrib>Degraff, Arthur C</creatorcontrib><creatorcontrib>Kupperman, Herbert S</creatorcontrib><title>Effect of Hypoadrenalism and Excessive Doses of Desoxycorticosterone Acetate upon Response of the Rat to Ouabain</title><title>Circulation research</title><addtitle>Circ Res</addtitle><description>The influence of alterations of adrenal function upon the responsiveness of the rat to intravenously administered ouabain was studied electrocardiographically by the string galvanometer. Conduction disturbances followed by cardiac arrest were the criteria for a definitive response. Adrenalectomized rats showed a significant increase in sensitivity to ouabain as compared with normal controls. Normal animals implanted with pellets of desoxycorticosterone acetate and continuously maintained on saline drinking water did not show a significant alteration in their responsiveness to ouabain.</description><subject>Adrenal Glands - surgery</subject><subject>Adrenal Insufficiency</subject><subject>Animals</subject><subject>Desoxycorticosterone - pharmacology</subject><subject>Desoxycorticosterone Acetate</subject><subject>Heart - drug effects</subject><subject>Old Medline</subject><subject>Ouabain</subject><subject>Rats</subject><subject>Strophanthins</subject><issn>0009-7330</issn><issn>1524-4571</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1955</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkU1r3DAQhkVpSbZprj0WnXrzVqMPWzqGZNMUAoFtexayPGLdei3XkpPsv4-WXShzeJnhmTk8Q8hnYGuAGr4xWG83P9eiFNfsHVmB4rKSqoH3ZMUYM1UjBLskH1P6wxhIwc0FuSxZy6ZWKzJtQkCfaQz04TBF1804uqFPe-rGjm5ePabUPyO9iwnTkbrDFF8PPs659zFlnOOI9MZjdhnpMsWRbjGVSHik8w7p1mWaI31aXOv68RP5ENyQ8PqcV-T3_ebX7UP1-PT9x-3NY-UlCF0FJV3gPGiFbc11Z7hxEjgYLhVXbVejNFBr1YiO-abGFgN2HbCaGW1804gr8vV0d5rjvwVTtvs-eRwGN2JcktWgGDdKF3B9Av0cU5ox2Gnu924-WGD26NgysMWxFaWK47Lw5Xx5affY_cfPUgsgT8BLHIqg9HdYXnC2O3RD3tnyFCYY8AqMUkyVrjqOtHgD76SHTw</recordid><startdate>195505</startdate><enddate>195505</enddate><creator>Unterman, David</creator><creator>Degraff, Arthur C</creator><creator>Kupperman, Herbert S</creator><general>American Heart Association, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>195505</creationdate><title>Effect of Hypoadrenalism and Excessive Doses of Desoxycorticosterone Acetate upon Response of the Rat to Ouabain</title><author>Unterman, David ; Degraff, Arthur C ; Kupperman, Herbert S</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4138-f54af22f85eb628d929a4121924525bd6e49168573d0c76ebefedd1060989c773</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1955</creationdate><topic>Adrenal Glands - surgery</topic><topic>Adrenal Insufficiency</topic><topic>Animals</topic><topic>Desoxycorticosterone - pharmacology</topic><topic>Desoxycorticosterone Acetate</topic><topic>Heart - drug effects</topic><topic>Old Medline</topic><topic>Ouabain</topic><topic>Rats</topic><topic>Strophanthins</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Unterman, David</creatorcontrib><creatorcontrib>Degraff, Arthur C</creatorcontrib><creatorcontrib>Kupperman, Herbert S</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Circulation research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Unterman, David</au><au>Degraff, Arthur C</au><au>Kupperman, Herbert S</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of Hypoadrenalism and Excessive Doses of Desoxycorticosterone Acetate upon Response of the Rat to Ouabain</atitle><jtitle>Circulation research</jtitle><addtitle>Circ Res</addtitle><date>1955-05</date><risdate>1955</risdate><volume>3</volume><issue>3</issue><spage>280</spage><epage>284</epage><pages>280-284</pages><issn>0009-7330</issn><eissn>1524-4571</eissn><abstract>The influence of alterations of adrenal function upon the responsiveness of the rat to intravenously administered ouabain was studied electrocardiographically by the string galvanometer. Conduction disturbances followed by cardiac arrest were the criteria for a definitive response. Adrenalectomized rats showed a significant increase in sensitivity to ouabain as compared with normal controls. Normal animals implanted with pellets of desoxycorticosterone acetate and continuously maintained on saline drinking water did not show a significant alteration in their responsiveness to ouabain.</abstract><cop>United States</cop><pub>American Heart Association, Inc</pub><pmid>14364765</pmid><doi>10.1161/01.RES.3.3.280</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Circulation research, 1955-05, Vol.3 (3), p.280-284 |
| issn | 0009-7330 1524-4571 |
| language | eng |
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| source | MEDLINE; American Heart Association Journals; Journals@Ovid Complete; EZB-FREE-00999 freely available EZB journals |
| subjects | Adrenal Glands - surgery Adrenal Insufficiency Animals Desoxycorticosterone - pharmacology Desoxycorticosterone Acetate Heart - drug effects Old Medline Ouabain Rats Strophanthins |
| title | Effect of Hypoadrenalism and Excessive Doses of Desoxycorticosterone Acetate upon Response of the Rat to Ouabain |
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