Microtubular inclusions in normal skin of systemic lupus erythematosus patients
Biopsy specimens of clinically normal skin of 9 consecutive patients with SLE were examined ultrastructurally to determine the presence and frequency of microtubular inclusions. Ten blood vessels were examined in each specimen; every specimen contained at least two positive blood vessels, and some c...
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| Veröffentlicht in: | Arthritis and rheumatism 1972-03, Vol.15 (2), p.193-200 |
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| container_title | Arthritis and rheumatism |
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| creator | Nieland, Nancy Wanger Hashimoto, Ken Masi, Alfonse T. |
| description | Biopsy specimens of clinically normal skin of 9 consecutive patients with SLE were examined ultrastructurally to determine the presence and frequency of microtubular inclusions. Ten blood vessels were examined in each specimen; every specimen contained at least two positive blood vessels, and some contained 80 to 100% positive vessels. No correlation was found between the frequency of the inclusions and either the disease duration or antinuclear factor titer. The inclusions tended to be more frequent in patients with more acute disease. The absence of inclusions in normal skin may mitigate a diagnosis of SLE. |
| doi_str_mv | 10.1002/art.1780150210 |
| format | Article |
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Ten blood vessels were examined in each specimen; every specimen contained at least two positive blood vessels, and some contained 80 to 100% positive vessels. No correlation was found between the frequency of the inclusions and either the disease duration or antinuclear factor titer. The inclusions tended to be more frequent in patients with more acute disease. 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Ten blood vessels were examined in each specimen; every specimen contained at least two positive blood vessels, and some contained 80 to 100% positive vessels. No correlation was found between the frequency of the inclusions and either the disease duration or antinuclear factor titer. The inclusions tended to be more frequent in patients with more acute disease. The absence of inclusions in normal skin may mitigate a diagnosis of SLE.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Antibodies, Antinuclear - analysis</subject><subject>Arteries - pathology</subject><subject>Biopsy</subject><subject>Capillaries - pathology</subject><subject>Female</subject><subject>Humans</subject><subject>Lupus Erythematosus, Systemic - immunology</subject><subject>Lupus Erythematosus, Systemic - pathology</subject><subject>Microscopy, Electron</subject><subject>Microtubules</subject><subject>Skin - pathology</subject><subject>Veins - pathology</subject><issn>0004-3591</issn><issn>1529-0131</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1972</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkElLA0EQhRtRYoxevQlz8jaxepvlGIIbRAISz01PTw2Ozmb3NDL_3pYE9eapXvFefVCPkEsKSwrAbrQdlzTNgEpgFI7InEqWx0A5PSZzABAxlzk9JWfOvYWVcclnZCYkTznwOdk-1cb2oy98o21Ud6bxru47F2TU9bbVTeTeg-6ryE1uxLY2UeMH7yK00_iKrR57F7ZBjzV2ozsnJ5VuHF4c5oK83N3u1g_xZnv_uF5tYsMFQFzwTBbImUaWp5muGMsR0jyVKEWZUBAZ1yjQIC0NJKWRIDAzQrMSE87SlC_I9Z472P7DoxtVWzuDTaM77L1TGRUyEwmE4HIfDG86Z7FSg61bbSdFQX03qEKD6rfBcHB1IPuixfInfqgs-Pne_6wbnP6hqdXz7g_7C2W7fes</recordid><startdate>197203</startdate><enddate>197203</enddate><creator>Nieland, Nancy Wanger</creator><creator>Hashimoto, Ken</creator><creator>Masi, Alfonse T.</creator><general>John Wiley & Sons, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>197203</creationdate><title>Microtubular inclusions in normal skin of systemic lupus erythematosus patients</title><author>Nieland, Nancy Wanger ; Hashimoto, Ken ; Masi, Alfonse T.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3400-b385be32ae2978af229e07975e54d610483ae4ece1dc06dc504e8c4a2de632773</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1972</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Antibodies, Antinuclear - analysis</topic><topic>Arteries - pathology</topic><topic>Biopsy</topic><topic>Capillaries - pathology</topic><topic>Female</topic><topic>Humans</topic><topic>Lupus Erythematosus, Systemic - immunology</topic><topic>Lupus Erythematosus, Systemic - pathology</topic><topic>Microscopy, Electron</topic><topic>Microtubules</topic><topic>Skin - pathology</topic><topic>Veins - pathology</topic><toplevel>online_resources</toplevel><creatorcontrib>Nieland, Nancy Wanger</creatorcontrib><creatorcontrib>Hashimoto, Ken</creatorcontrib><creatorcontrib>Masi, Alfonse T.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Arthritis and rheumatism</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Nieland, Nancy Wanger</au><au>Hashimoto, Ken</au><au>Masi, Alfonse T.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Microtubular inclusions in normal skin of systemic lupus erythematosus patients</atitle><jtitle>Arthritis and rheumatism</jtitle><addtitle>Arthritis Rheum</addtitle><date>1972-03</date><risdate>1972</risdate><volume>15</volume><issue>2</issue><spage>193</spage><epage>200</epage><pages>193-200</pages><issn>0004-3591</issn><eissn>1529-0131</eissn><abstract>Biopsy specimens of clinically normal skin of 9 consecutive patients with SLE were examined ultrastructurally to determine the presence and frequency of microtubular inclusions. Ten blood vessels were examined in each specimen; every specimen contained at least two positive blood vessels, and some contained 80 to 100% positive vessels. No correlation was found between the frequency of the inclusions and either the disease duration or antinuclear factor titer. The inclusions tended to be more frequent in patients with more acute disease. The absence of inclusions in normal skin may mitigate a diagnosis of SLE.</abstract><cop>New York</cop><pub>John Wiley & Sons, Inc</pub><pmid>4537303</pmid><doi>10.1002/art.1780150210</doi><tpages>8</tpages></addata></record> |
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| ispartof | Arthritis and rheumatism, 1972-03, Vol.15 (2), p.193-200 |
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| language | eng |
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| source | MEDLINE; Wiley Online Library All Journals; Alma/SFX Local Collection |
| subjects | Adolescent Adult Antibodies, Antinuclear - analysis Arteries - pathology Biopsy Capillaries - pathology Female Humans Lupus Erythematosus, Systemic - immunology Lupus Erythematosus, Systemic - pathology Microscopy, Electron Microtubules Skin - pathology Veins - pathology |
| title | Microtubular inclusions in normal skin of systemic lupus erythematosus patients |
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